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General Description

Awareness is growing that the rainforests are one of the world’s greatest natural resources.  Based on current knowledge, it is estimated that the rainforests contain 170,000 of the world's 250,000 known plant species, and more are still being discovered.  Continuing scientific studies are revealing many to be greatly beneficial for a broad number of medicinal uses.

As you will find in the study abstracts that follow, one of the most unique in its diversity and potential in medicinal applications is SAMENTO, also known as TOA-Free Cat's Claw.  SAMENTO is a rare chemotype of the medicinal plant commonly known as Cat's Claw, Uncaria tomentosa.

Samento was approved as a medicine in Ecuador in 2004. Government officials have allowed 3 drug claims to be used: anti-inflammatory, antimicrobial and immune system modulator. The Hungarian National Institute of Pharmacy (OGYI), the Hungarian equivalent of the FDA in the US, also approved SAMENTO in 2001 as paramedicament (OTC) pharmaceutical preparation as a “sole or adjunct therapy for rheumatoid diseases, arthritis, and locomotor conditions.  It is also approved as a sole or adjunct therapy to enhance immune system function.

Unlike traditional Cat's Claw products, the SAMENTO chemotype does not contain Tetracyclic Oxindole Alkaloids (TOAs), a group of chemical antagonists that act upon the central nervous system and can greatly inhibit the positive effect of the Pentacyclic Oxindole Alkaloids (POAs). The POAs primarily affect the immune cells responsible for nonspecific and cellular immunity and demonstrate powerful immune system modulating properties. According to research conducted in Austria, traditional Cat's Claw products may contain as much as 80% TOAs, and as little as 1% TOAs can cause a 30% reduction in the immune system modulating properties that POAs provide. 

As a result of these phytochemical differences between SAMENTO and Cat's Claw, SAMENTO can be safely used in a broader range of medical conditions.  Cat’s Claw acts as an immune system stimulant making it contraindicated in patients with autoimmune disorders, whereas SAMENTO is an immune system modulator. For this reason, SAMENTO can be used to treat all autoimmune disorders.

TOA-Free Cat’s Claw (SAMENTO) and isolated POAs such as mitraphylline, isomytraphylline, isopteropodine, and pteropodine continue to show promising results as they have been studied.  The studies below reveal the exciting potential for the use of SAMENTO in various applications.

Some Reported Medicinal Properties

















Reasearch On Nutramedix Product


Priyanka A.S. Theophilus M.S., Eva Sapi Ph.D. (2013). In Vitro Effect of Peruvian Antimicrobial Agents on Borrelia burgdorferi Full Article


I. Urdanibia, O. Estrada, P. Taylor (2007). The antitumor effect of Samento, pentacyclic chemotype of Uncaria tomentosa, is probably due to its anti-inflammatory activity. Full Article


Establishment of the Potential Anti-inflammatory Effect of the product known as Samento.  The study demonstrated that Samento had a marked anti-inflammatory effect and was 86% as effective as Feldene, a non-steroidal anti-inflammatory drug also known as PIROXICAM. University of Guayaquil, Department of Chemical Sciences, Guayaquil, Ecuador (2005) Full Article


Pilot Study: Effective Treatment of Lyme Borreliosis with Pentacyclic Alkaloid Uncaria tomentosa (TOA-free Cat’s Claw), Dallas, Texas, 2003. Full Article


Clinical Study: Use of Samento in Patients with Neurodystonia, L. Kaitazki, MD, Medical Institution of Internal Government Affairs, Bulgaria (2003) (N/A). Full Article


An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Samento did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

Medical Conditions [peer-reviewed journals]

Alzheimer’s disease

Researchers Report That a Natural Plant Derivative From the Amazon Rain Forest in a Rodent Model Inhibits the Deposition of Beta-amyloid Deposits Associated With Alzheimer's Disease Plaques.. (n.d.) >The Free Library. (2014). Retrieved Jun 20 2018 from Full Article


Dietrich, F., Kaiser, S., Rockenbach, L., Figueiró, F., Bergamin, L. S., da Cunha, F. M., ... & Battastini, A. M. O. (2014). Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell lineFood and chemical toxicology67, 222-229. Full Article


Prado, E. G., Gimenez, M. G., De la Puerta Vázquez, R., Sánchez, J. E., & Rodriguez, M. S. (2007). Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine, 14(4), 280-284. Full Article


Baraya, Y. U. S. A. B., Wong, K. K., & Yaacob, N. S. (2017). The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: a review. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 17(6), 770-783. Full Article

García Giménez, M. D., García Prado, E., Sáenz Rodríguez, M. T., Fernández Arche, M. D. L. Á., & Puerta Vázquez-Zafra, R. D. L. (2010). Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines. Planta Medica, 76, 133-136. Full Article

Riva, L., Coradini, D., Di, G. F., De, V. F., De, N. T., De, F. S., & Pizza, C. (2001). The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Research, 21(4A), 2457-2461. Full Article


Dietrich, F., Martins, J. P., Kaiser, S., Silva, R. B. M., Rockenbach, L., Edelweiss, M. I. A., ... & Battastini, A. M. O. (2015). The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in mice. PloS one, 10(7), e0131882. Full Article


Reis, S. R. I., Valente, L. M., Sampaio, A. L., Siani, A. C., Gandini, M., Azeredo, E. L., ... & Kubelka, C. F. (2008). Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2. International Immunopharmacology, 8(3), 468-476. Full Article


Tay, L. Y., Dos Santos, F. A., & Jorge, J. H. (2015). Uncaria tomentosa gel against denture stomatitis: clinical report. Journal of Prosthodontics, 24(7), 594-597. Full Article


Neto, J. N., Coelho, T. M., Aguiar, G. C., Carvalho, L. R., de Araújo, A. G. P., Girão, M. J. B., & Schor, E. (2011). Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract. European Journal of Obstetrics and Gynecology and Reproductive Biology, 154(2), 205-208. Full Article


Caon, T., Kaiser, S., Feltrin, C., de Carvalho, A., Sincero, T. C. M., Ortega, G. G., & Simões, C. M. O. (2014). Antimutagenic and antiherpetic activities of different preparations from Uncaria tomentosa (cat’s claw). Food and Chemical Toxicology, 66, 30-35. Full Article

Immune-mediated diseases (diabetes)                   

Domingues, A., Sartori, A., Golim, M. A., Valente, L. M. M., da Rosa, L. C., Ishikawa, L. L. W., ... & Viero, R. M. (2011). Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?. Journal of Ethnopharmacology, 137(1), 635-642. Full Article


Pilarski, R., Poczekaj-Kostrzewska, M., Ciesiolka, D., Szyfter, K., & Gulewicz, K. (2007). Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells. Pharmacological reports, 59(5), 565. Full Article


Eberlin, S., dos Santos, L. M., & Queiroz, M. L. (2005). Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes. International Immunopharmacology, 5(7-8), 1235-1246. Full Article


Datar, A. N., Kaur, N., Patel, S., Luecke, D. F., & Sapi, E. (2010). In Vitro Effectiveness of Samento and Banderol Herbal Extracts on Different Morphological Forms of Borrelia Burgdorferi (Doctoral dissertation, University of New Haven). Full Article


Piscoya, J., Rodriguez, Z., Bustamante, S. A., Okuhama, N. N., Miller, M. J. S., & Sandoval, M. (2001). Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflammation Research, 50(9), 442-448. Full Article

Rheumatoid Arthritis

Mur, E., Hartig, F., Eibl, G., & Schirmer, M. (2002). Randomized double-blind trial of an extract from the pentacyclic alkaloid-chemotype of uncaria tomentosa for the treatment of rheumatoid arthritis. The Journal of Rheumatology, 29(4), 678-681. Full Article


Ciani, F., Tafuri, S., Troiano, A., Cimmino, A., Fioretto, B. S., Guarino, A. M., ... & Calabrò, V. (2018). Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cells. Journal of Ethnopharmacology, 211, 285-294. Full Article


Rinner, B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R. (2009). Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells. Anticancer Research, 29(11), 4519-4528. Full Article


Santos, K. F., Gutierres, J. M., Pillat, M. M., Rissi, V. B., dos Santos Araújo, M. D. C., Bertol, G., ... & Morsch, V. M. (2016). Uncaria tomentosa extract alters the catabolism of adenine nucleotides and expression of ecto-5′-nucleotidase/CD73 and P2X7 and A1 receptors in the MDA-MB-231 cell line. Journal of Ethnopharmacology, 194, 108-116. Full Article

de Paula, L. C. L., Fonseca, F., Perazzo, F., Cruz, F. M., Cubero, D., Trufelli, D. C., ... & del Giglio, A. (2015). Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumors. The Journal of Alternative and Complementary Medicine, 21(1), 22-30. Full Article

Dreifuss, A. A., Bastos-Pereira, A. L., Ávila, T. V., da Silva Soley, B., Rivero, A. J., Aguilar, J. L., & Acco, A. (2010). Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa)(Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model. Journal of Ethnopharmacology, 130(1), 127-133. Full Article

Medicinal Properties [peer-reviewed journals]

Adjunctive to Chemotherapy

Allen, L., Buckner, A., Buckner, C. A., Cano, P., & Lafrenie, R. M. (2017). Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae) sensitizes THP-1 cells to radiation-induced cell death. Pharmacognosy Research, 9(3), 221. Full Article

Farias, I., do Carmo Araújo, M., Zimmermann, E. S., Dalmora, S. L., Benedetti, A. L., Alvarez-Silva, M., ... & Schetinger, M. R. C. (2011). Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells. Journal of Ethnopharmacology, 137(1), 856-863. Full Article


Nowakowska, J., Bany, J., Zdanowska, D., Czubaj, A., Kuraś, M., & Skopińska-Różewska, E. (2009). Experimental Immunology: The effect of the bark water extract Uncaria tomentosa on the Pseudomonas aeruginosa infection in mice. Central European Journal of Immunology, 34(3), 162-165. Full Article


Moraes, R. C., Carvalho, A. R., Lana, A. J. D., Kaiser, S., Pippi, B., Fuentefria, A. M., & Ortega, G. G. (2017). In vitro synergism of a water insoluble fraction of Uncaria tomentosa combined with fluconazole and terbinafine against resistant non-Candida albicans isolates. Pharmaceutical biology, 55(1), 406-415. Full Article

Moraes, R. C., Dalla Lana, A. J., Kaiser, S., Carvalho, A. R., de Oliveira, L. F. S., Fuentefria, A. M., & Ortega, G. G. (2015). Antifungal activity of Uncaria tomentosa (Willd.) DC against resistant non-albicans Candida isolates. Industrial Crops and Products, 69, 7-14. Full Article


Montserrat-de la Paz, S., Fernandez-Arche, A., de la Puerta, R., Quilez, A. M., Muriana, F. J., Garcia-Gimenez, M. D., & Bermudez, B. (2016). Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine, 23(2), 141-148. Full Article

Rojas-Duran, R., González-Aspajo, G., Ruiz-Martel, C., Bourdy, G., Doroteo-Ortega, V. H., Alban-Castillo, J., ... & Deharo, E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143(3), 801-804. Full Article

Gonçalves, C., Dinis, T., & Batista, M. T. (2005). Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry, 66(1), 89-98. Full Article

Antigenotoxic and Antimutagenic

Paniagua‐Pérez, R., Madrigal‐Bujaidar, E., Molina‐Jasso, D., Reyes‐Cadena, S., Álvarez‐González, I., Sánchez‐Chapul, L., & Pérez‐Gallaga, J. (2009). Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine. Basic & clinical pharmacology & toxicology, 104(3), 222-227. Full Article


Herrera, D. R., Tay, L. Y., Rezende, E. C., Kozlowski Jr, V. A., & dos Santos, E. B. (2010). In vitro antimicrobial activity of phytotherapic Uncaria tomentosa against endodontic pathogens. Journal of oral science, 52(3), 473-476. Full Article


Dreifuss, A. A., Bastos-Pereira, A. L., Fabossi, I. A., dos Reis Lívero, F. A., Stolf, A. M., de Souza, C. E. A., ... & Teixeira, S. (2013). Uncaria tomentosa exerts extensive anti-neoplastic effects against the Walker-256 tumor by modulating oxidative stress and not by alkaloid activity. PLoS One, 8(2), e54618. Full Article

Rinner, B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R. (2009). Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells. Anticancer research, 29(11), 4519-4528. Full Article


Bukowska, B., Bors, M., Gulewicz, K., & Koter-Michalak, M. (2012). Uncaria tomentosa extracts protect human erythrocyte catalase against damage induced by 2, 4-D-Na and its metabolites. Food and Chemical Toxicology, 50(6), 2123-2127. Full Article

Amaral, S., Mira, L., Nogueira, J. M. F., da Silva, A. P., & Florêncio, M. H. (2009). Plant extracts with anti-inflammatory properties—A new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships. Bioorganic & Medicinal Chemistry, 17(5), 1876-1883. Full Article

Trejo‐Tapia, G., Sepúlveda‐Jiménez, G., Trejo‐Espino, J. L., Cerda‐García‐Rojas, C. M., De La Torre, M., Rodríguez‐Monroy, M., & Ramos‐Valdivia, A. C. (2007). Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) DC cell suspension cultures via oxidative burst. Biotechnology and Bioengineering, 98(1), 230-238. Full Article

Cisneros, F. J., Jayo, M., & Niedziela, L. (2005). An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation. Journal of Ethnopharmacology, 96(3), 355-364. Full Article

Central Nervous System (CNS) Support

Kang, T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ... & Watanabe, H. (2002). Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte. European journal of pharmacology, 444(1-2), 39-45. Full Article


Sandoval, M., Charbonnet, R. M., Okuhama, N. N., Roberts, J., Krenova, Z., Trentacosti, A. M., & Miller, M. J. (2000). Cat’s claw inhibits TNFα production and scavenges free radicals: role in cytoprotection. Free Radical Biology and Medicine, 29(1), 71-78. Full Article


Lozada-Requena, I., Núñez, C., Alvárez, Y., Kahn, L., & Aguilar, J. (2015). Lymphocyte subsets, dendritic cells and cytokine profiles in mice with melanoma treated with Uncaria tomentosa. Revista Peruana de Medicina Experimental y Salud Publica, 32(4), 633-642. (Spanish). Full Article

Núñez, C., Lozada-Requena, I., Ysmodes, T., Zegarra, D., Saldaña, F., & Aguilar, J. (2015). Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer. Revista Peruana de Medicina Experimental y Salud Publica, 32(4), 643-651. Full Article

Montserrat-De La Paz, S., De la Puerta, R., Fernandez-Arche, A., Quilez, A. M., Muriana, F. J. G., Garcia-Gimenez, M. D., & Bermudez, B. (2015). Pharmacological effects of mitraphylline from Uncaria tomentosa in primary human monocytes: skew toward M2 macrophages. Journal of Ethnopharmacology, 170, 128-135. Full Article

Domingues, A., Sartori, A., Valente, L. M. M., Golim, M. A., Siani, A. C., & Viero, R. M. (2011). Uncaria tomentosa Aqueous‐ethanol Extract Triggers an Immunomodulation toward a Th2 Cytokine Profile. Phytotherapy Research, 25(8), 1229-1235. Full Article

Kang, T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ... & Watanabe, H. (2002). Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyte. European Journal of Pharmacology, 444(1-2), 39-45. Full Article

Karl-Heinz Reinhard (1999). Uncaria tomentosa (Willd.) D.C.: Cat's Claw, Una de Gato, or Saventaro. The Journal of Alternative and Complementary Medicine, pp. 143-151 Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Lyme disease

Why this Finnish Doctor Believes in Herbs, Marjo Valonen MD, Townsend Letter, July 2018 Full Article

A Hidden Epidemic: Integrative Treatment of Lyme Disease, Scott Forsgren, March 2009 Full Article

Chronic Fatigue Often Misdiagnosed Lyme: Is Samento An Answer?, Complementary and Alternative Medicine, October 2004. Full Article

Samento: New Remedy for an Ancient Enemy—Lyme Disease, James South, Vitamin Research News, Vol. 18, Number 6, July 2004. Full Article

Rheumatoid Arthritis                                                                                             

Live Blood Analysis: Treatment of Rheumatoid Arthritis, Arthritis and Colon Cancer with Samento (2002), Professor Henk Oswald, M.D., Ph.D., Amsterdam, Netherlands. Full Article

Various Medical Conditions

Samento in the Primary Care Setting, John Kule, MD. British Naturopathic Journal, Vol. 19, No. 2, 2002. Full Article

Why Samento Successfully Treats Over 100 Diseases, Atanas Tzonkov, Director of Lechitel Health Center, Lechitel Weekly, April 2002. Full Article                                                       


Conference Presentations

Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video

Report on Tetracyclic Oxindole-free Uncaria Tomentosa also known as Cat’s Claw or Una de Gato, presented by Michael Coyle, NuLife Sciences at the Samento Conference, Florida, USA, May 2002. Full Article

Samento Normalizes Blood Pressure (Preliminary Data) Associate professor Ludmila Ivanova, MD, Ph.D., presented at the 4th Annual Samento Conference, Sofia, Bulgaria, October 2003. Full Article

A Rare Chance for Humanity- presented by Brian Lamb, Medical Herbalist, Scotland at the International Samento Conference, Sofia, Bulgaria, March 22, 2001. Full Article

Patient Reports

"A 'must have' in your Lyme-treatment arsenal." -G.W.

"Found out about Samento from my dogs' veterinarian. I'm adding it to her raw food diet because of H. pylori and lime disease that she had. Also, I'm taking it as well, since we live under one roof and H. pylori are contagious."  -F.L.

"This stuff is amazing for Lyme's Disease. It really does work and I notice rheumatic and arthritic pain beginning to go away in my joints." -S.O.

“Have been taking this daily for the past 22 years... keeps you healthy. You can fight off colds and flu fast and most of the time you never get them” – D.K

“I've been using Samento when needed for about 8 years. I have an auto-immune disease and get frequent bladder infections. Samento will clear up most of them. Follow directions! It may be OTC but still powerful. Don't take 2x suggested dose thinking it will work faster. Notice it says to let sit in water for 1 minute before taking”. - K.B

Dosage Information

30 drops twice daily at least 30 minutes before meals (start with 1 drop in 4 oz. of water adding a drop with each dose).


Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Samento did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

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Samento: Uncaria tomentosa, Cat's Claw, Una de Gato, or Saventaro

Recently, Uncaria tomentosa (Willd.) D.C. has become known as a healing plant with an eth­nomedicinal background. There have been several reports on its constituents, in particular, oxindole alkaloids. It was found that 2 chemotypes of Uncaria tomentosa with different al­kaloid patterns occur in nature.

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Samento: Chronic Fatigue

An informal study conducted by the American Lyme Disease Alliance (ALDA), found that most patients diagnosed with Chronic Fatigue Syndrome (CFS) were actually suffering from Lyme disease. Out of a group of CFS 31 patients, 28 were found to be ill as a result of Lyme.

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Lyme Disease: A Hidden Epidemic

Many people think of Lyme disease as a simple illness caused by the bite of an infected tick.Though a bite may be a triggering event, this perspective is simplistic and does not take into consideration the numerous issues that both the patient and doctor must consider and treat in order to attain the best possible outcomes. Furthermore, medical literature suggests that Lyme disease is a complex illness which may be transmitted by mosquito bites, blood transfusions, sexual intercourse and many other ways.

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Lyme Disease: Why This Finnish Doctor Believes in Herbs

From an early age, I had a great interest in medicine. When I was young, I thought I wanted to be a brain surgeon. Later, in medical school at the University of Turku, Finland, everything interested me. I was also lucky enough to study a course on acupuncture, something that is not normally taught in Finnish medical schools.

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Samento: Treats Over 100 Diseases

Despite the widespread belief that no remedy can treat more than a couple of diseases, the truth is entirely different. Even in conventional medicamental medicine, there are drugs -for instance corticosteroids or non-steroidal anti-inflammatory drugs - that do treat or positively influence a large number of "diseases" or clinical symptoms. Additionally many antibiotics, in spite of their apparent or relative specificity, successfully treat quite a large number of different bacterial infections.

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Samento: Neurodystonia

The remedy SAMENTO has an exceptionally broad spectrum of therapeutic effect in different types of internal, endocrine, dermatological, neurological, oncological, immunodeficiency and many other diseases. A clinical study was carried out at LECHITEL Medical Center on 24 patients diagnosed with “Dystonia neurovegetativa”.

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Samento: Tumors

Use of cat’s claw might be beneficial in patients with advanced cancer by improving their quality of life and reducing fatigue. The mechanism of action does not seem to be related to the anti-inflammatory properties of this plant.

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Samento: Antitumoral and Antioxidant Effects

UT hydroalcoholic extract successfully reduced the tumor growth. In addition, treatment with UT reduced the activity of AST, which had been increased as a result of tumor inoculation, thus attempting to return it to normal levels. UT did not reverse the increase of LDH and GGT plasma levels, although all doses were remarkably effective in reducing urea plasma levels.

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Samento: Tetracylic Oxindole-free

This is a report on the efficacy of tetracyclic oxindole free Uncaria Tomentosa, commonly known as TOA-free Cat’s Claw or Una de Gato which is distributed under the brand-name Samento. This research has been performed and published by NuLife Sciences, Inc. based on clinical observations which were recorded as photocomparative studies of observations on the Native blood in conjunction with a coagulation screening methodology known as the Oxidative Stress Test (Dried Blood Evaluation Screen).

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Samento: Thyroid Cancer

Medullary thyroid carcinoma (MTC), a rare calcitonin-producing tumor, is derived from parafollicular Ccells of the thyroid and is characterized by constitutive Bcl2 overexpression. The tumor is relatively insensitive to radiation therapy as well as conventional chemotherapy. To date, the only curative treatment is the early and complete surgical removal of all neoplastic tissue.

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Samento: Skin Cancer

Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as uña de gato, is a plant that grows wild in the upper Amazon region of Peru and has been widely used in folk medicine to treat several health conditions including cancer. We have produced an aqueous extract from Uncaria tomentosa (UT-ex) and analyzed its effects on squamous carcinoma cells and immortalized HaCaT keratinocytes.

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Samento: Lyme Disease

Lyme disease was first recognized around 1975, when a mysterious outbreak of juvenile rheumatoid arthritis occurred around Lyme, Connecticut. In 1982, the causative agent of Lyme disease was discovered by Willy Burgdorfer. It turned out to be a spirochete (spiral-shaped bacterium) from the genus Borrelia, subsequently named Borrelia burgdorferi (Bb).

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Samento: Antitumor Effect

Samento: pentacyclic chemotype (TOA free) of Uncaria tomentosa. The same botanical species that appears in other forms (composition of different secondary metabolites) due to different growing conditions 2 • Pentacyclic oxindole alkaloids (POA) • Tetracyclic oxindole alkaloids(TOA) Inhibits NF-B, and the production of TNF-, inhibits proliferation of human lymphoblasts and promotes phagocytosis Antagonistic effects on POA, decreasing its effect.

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Samento in the Primary Care Setting

Recent advances in the chemical analysis of Cat's Claw have shed new light on its use as a natural therapeutic agent. Specifically, it has been found that the clinical efficacy increases as the pentacyclic oxindole alkaloid (POA) fraction increases and as the tetracyclic oxindole alkaloid (TOA) content decreases respectively. Samento ( Uncaria tomentosa) is a rare form of Cat's Claw that has been found to be 100 per cent TOA free.

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Samento: Toxicity

Samento will be used in humans because of the vital importance of carrying out these first-step tests. They will not only guarantee the quality of the product, but will also establish that there are no adverse side effects in humans who take the product. As discussed in numerous international works, the study of acute toxicity is indispensable, and guarantees (within the margin of error associated with the technique) that the potential for toxicity from the compounds that will be ingested or that may enter into the system accidentally will be learned.

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Samento: Anti-inflammatory Effect

The auricular edema is achieved by applying 12-0- Tetradecanoil Forbol-13 Acetate (TPA), one of the components responsible for the irritating action of croton oil, into the auditory pavilion of the mouse. The inflammatory reaction consists of erythema, edema and infiltration by polymorphonuclear leukocytes. As such, eicosanoid -type mediators are freed, inducing degranulation of the mast cell. This technique thus allows the evaluation of the inhibiting substances of the biosynthesis of prostaglandins and leukotrienes.

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Samento: Rheumatiod Arthritis

Twenty-four weeks of treatment with the UT extract resulted in a reduction of the number of painful joints compared to placebo (by 53.2% vs. 24.1%; p=0.044). Patients receiving the UT extract only during the second phase experienced a reduction in the number of painful (p=0.003) and swollen joints (p=0.007) and the Ritchie Index (p=0.004) compared to the values after 24 weeks of placebo. Only minor effects were observed.

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Samento: A Rare Chance For Humanity

I am in charge of the largest phytotherapy clinic in Scotland and give lectures in the United States on weight control, nutrition and diabetes prevention. The aim of my visit here is not to share with you my clinical experience with Cat’s Claw but to help you understand how it works.

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Samento: Rheumatoid Arthritis, Arthritis, and Colon

The pictures on the following pages indicate the power and benefits of Samento. The "Before Treatment" photographs are of damaged blood cells due to free radical attack. The "After Treatment" photographs show cells after treatment with only Samento. Note how the attack of free radicals has damaged the cells. The formerly healthy cells have lost their integrity.

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Samento: Osteoarthritis

The purpose of this investigation was to evaluate the ability of cat’s claw, an Amazonian medicinal plant, to treat osteoarthritis of the knee, collect safety and tolerance information and compare the antioxidant, and anti-inflammatory actions of Uncaria guianensis and Uncaria tomentosa in vitro.

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Samento: Borrelia burgdorferi

Lyme Disease – The most common vector-borne infectious disease in the Northern United States. Number of people diagnosed with Lyme Disease each year in the US ≈300,000. Rapidly spreading throughout Europe and northeast Asia (The Centers for Disease Control and Prevention). New discoveries of ticks fossilized in amber show that the bacteria which cause it may have been lurking around for 15 million years.

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Samento: Lyme study

In a six-month prospective cohort study designed to compare the effectiveness of an alternative method of Lyme borreliosis treatment to conventional antibiotic treatment, patients receiving alternative treatment showed greater improvement based on self-reported disease symptoms, physician evaluation and clinical laboratory tests. The alternative treatment consisted of the use of Pentacyclic Alkaloid Chemotype Uncaria tomentosa, or TOA-Free Cat’s Claw, dietary and lifestyle changes, enzymes, vitamins, minerals, detoxification herbs and body pH-balancing. Conventional treatment included antibiotic treatment as recommended by the American Medical Association.

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Samento: Lyme Disease

A tick-borne, multisystemic disease, Lyme borreliosis caused by the spirochete Borrelia burgdorferi has grown into a major public health problem during the last 10 years. The primary treatment for chronic Lyme disease is administration of various antibiotics. However, relapse often occurs when antibiotic treatment is discontinued. One possible explanation for this is that B. burgdorferi become resistant to antibiotic treatment, by converting from their vegetative spirochete form into different round bodies and/or into biofilmlike colonies.

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Samento: Leukemia

The woody Amazonian vine Uncaria tomentosa (cat’s claw) has been recently more and more popular all over the world as an immunomodulatory, antiinflammatory and anti-cancer remedy. This study investigates anti-proliferative potency of several cat’s claw preparations with different quantitative and qualitative alkaloid contents on HL-60 acute promyelocytic human cells by applying trypan blue exclusion and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction assay (MTT).

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Samento: Immunomodulation

Uncaria tomentosa (Willd.) DC (Rubiaceae) is a large woody vine that is native to the Amazon and Central American rainforests and is used widely in traditional medicine for its immunomodulatory and antiinflammatory activities. The present work used in vivo immunotoxic and in vitro immunomodulatory experiments to investigate the effects of a pentacyclic oxindole alkaloid extract from U. tomentosa bark on lymphocyte phenotype, Th1/Th2 cytokine production, cellular proliferation and cytotoxicity.

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Samento: Immunomodulating (TH1))

Objetives: This study aimed to research the in vitro immunomodulatory effects of an Uncaria tomentosa hydroalcoholic extract standardized (5.03%, pentacyclic oxindole alkaloids) (UT-POA) on the immunophenotype of dendritic cells (DC) subsets, Th1, Th2, Th17 and IL-12 cytokines from patients with stage II breast cancer (BCII) and healthy women (H). Materials and methods. Blood of 11 H and 7 BCII was obtained, PBMC were isolated and cultured for 2h with/without various concentrations of UT-POA and stimulated or not with LPS for 24h. PBMC were labeled with specific antibodies for DC and in the supernatant we measured Th1/Th2/Th17 cytokines, both by flow cytometry. Furthermore IL-12 was measured by ELISA.

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Samento: Immunomodulating (dengue)

Ethnopharmacological relevance: Uncaria tomentosa (Willdenow ex Roemer & Schultes) DC. (Rubiaceae) is a Peruvian thorny liana, commonly known as “cat's claw”, and traditionally used in folk medicine to deal with several inflammatory diseases. Mitraphylline (MTP) is the most abundant pentacyclic oxindolic alkaloid (POA) from U. Tomentosa and has been reported to modify the inflammatory response.

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Samento: Immunomodulating (dendrite)

Objectives: To evaluate the immunomodulatory effect on lymphocyte subsets, dendritic cells (DC), Th1 / Th2 / Th17 and inflammatory cytokines on systemic level and/or in the tumor microenvironment of mice with or without melanoma. Materials and methods: Peripheral blood and/or primary tumors samples were obtained of mice with B16 melanoma treated or not with a hydroalcoholic extract of Uncaria tomentosa (UT) with 5.03% of pentacyclic oxindole alkaloids (UT-POA) obtained from the bark of the plant. All cell assays and cytokine measurements were performed by flow cytometry.

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Samento: Diabetes

Ethnopharmacological relevance: Uncaria tomentosa (Willd.) DC (Rubiaceae)is a species native to the Amazon rainforest and surrounding tropical areas that is endowed with immunomodulatory properties and widely used around the world. In this study we investigated the immunomodulatory potential of Uncaria tomentosa (UT) aqueous–ethanol extract on the progression of immune-mediated diabetes.

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Samento: Herpes

Uncaria tomentosa have been used to treat viral diseases such as herpes due to multiple pharmacological effects, but its therapeutic efficacy against this virus have not been reported yet. Thus, in vitro antiherpetic activity of hydroethanolic extract from barks, purified fractions of quinovic acid glycosides and oxindole alkaloids was evaluated by plaque reduction assay, including mechanistic studies (virucidal, attachment and penetration action).

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Samento: Endometriosis

Experimental endometriosis was induced in twenty-five female Wistar rats. After three weeks, 24 animals developed grade III experimental endometriosis and were divided into two groups. Group ‘‘U’’ received U. tomentosa extract orally (32 mg/day), and group ‘‘C’’ (control group) received a 0.9% sodium chloride solution orally (1 ml/100 g of body weight/day). Both groups were treated with gavage for 14 days.

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Samento: Denture Stomatitis

The objective of this study is to report the clinical use of 2% Uncaria tomentosa gel against denture stomatitis (DS) as an alternative treatment. The patient was a 65-year-old, denture-wearing woman. At the clinical examination, her palate showed hyperplasic and erythematous mucosa indicating DS type II. DS is a chronic oral disease that affects denture wearers. It occurs as an inflammatory reaction in denturewearing patients under maxillary prostheses.

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Samento: Dengue Fever

Uncaria tomentosa (Willd.) DC., a large woody vine native to the Amazon and Central American rainforests has been used medicinally by indigenous peoples since ancient times and has scientifically proven immunomodulating, anti-inflammatory, cytotoxic and antioxidant activities. Several inflammatory mediators that are implicated in vascular permeability and shock are produced after Dengue Virus (DENV) infection by monocytes, the primary targets for virus replication.

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Samento: Cytoprotection

Cat’s claw (Uncaria tomentosa) is a medicinal plant from the Amazon River basin that is widely used for inflammatory disorders and was previously described as an inhibitor of NF-kB. Cat’s claw was prepared as a decoction (water extraction) of micropulverized bark with and without concentration by freeze-drying. Murine macrophages (RAW 264.7 cells) were used in cytotoxicity assays (trypan blue exclusion) in response to the free radical 1,1-diphenyl2-picrilhydrazyl (DPPH, 0.3 mM) and ultraviolet light (UV) light.

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Samento: Cystitis

Uncaria tomentosa is widely used in folk medicine for the treatment of numerous diseases, such as urinary tract disease. Hemorrhagic cystitis (HE) is an inflammatory condition of the bladder associated with the use of anticancer drugs such as cyclophosphamide (CYP). Sodium 2-mercaptoethanesulfonate (Mesna) has been used to prevent the occurrence of HE, although this compound is not effective in established lesions.

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Samento: CNS-Immunomodulating

Pteropodine and isopteropodine are heteroyohimbine-type oxindole alkaloid components of Uncaria tomentosa (Willd.) DC, a Peruvian medicinal plant known as cat’s claw. In this study, the effects of these alkaloids on the function of Ca2+ -activated Cl  currents evoked by stimulation of G protein-coupled muscarinic M1 acetylcholine and 5-HT2 receptors were studied in Xenopus oocytes in which rat cortex total RNA was translated.

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Samento: Chemotherapy (THP)

Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae), known as Cat’s Claw or Uña de gato, is a traditionally used medicinal plant native to Peru. Some studies have shown that U. tomentosa can act as an antiapoptotic agent and enhance DNA repair in chemotherapy‑treated cells although others have shown that U. tomentosa enhanced apoptosis.

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Samento: Chemotherapy (progenitor)

Ethnopharmacological relevance: The Asháninkas, indigenous people of Peru, use cat’s claw (Uncaria tomentosa) to restore health. Uncaria tomentosa has antioxidant activity and works as an agent to repair DNA damage. It causes different effects on cell proliferation depending on the cell type involved; specifically, it can stimulate the proliferation of myeloid progenitors and cause apoptosis of neoplastic cells.

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Samento: Breast Cancer (Cytotoxic)

Preparations from Uncaria tomentosa, a South American Rubiaceae, have been used in the Peruvian traditional medicine for the treatment of infective, inflammatory and tumoral processes. In this study, the pentacyclic oxindole alkaloid mitraphylline was isolated from the dried inner bark of this plant species, and its structure elucidated by analysis of NMR spectroscopic data.

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Samento: Antiproliferative Effects

Uncaria tomentosa inner bark extract is a popular plant remedy used in folk medicine to treat tumor and inflammatory processes. In this study, the anti-tumoral effects of its pentacyclic alkaloid mitraphylline were investigated. Furthermore, its growth-inhibitory and cytotoxic effects on glioma GAMG and neuroblastoma SKN­BE(2) cell lines were studied using cyclophosphamide and vincristine as controls.

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Samento Induces Cell Death

Bladder cancer is the second most prevalent malignancy in the genitourinary tract and remains a therapeutic challenge. In the search for new treatments, researchers have attempted to find compounds with low toxicity. With this goal in mind, Uncaria tomentosa is noteworthy because the bark and root of this species are widely used in traditional medicine and in adjuvant therapy for the treatment of numerous diseases.

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Samento: Antigenotoxic, Antioxidant, and Lymphocyte Induction Effects

Pteropodine is a heterohimbine-type oxindole alkaloid specifically isolated from ‘Cat’s claw’ (Uncaria tomentosa), a plant that has shown cytostatic, anti-inflammatory and antimutagenic properties and is used in traditional medicine to cure a number of diseases. In this report, we studied the ability of pteropodine to decrease the rate of sister-chromatid exchanges and micronucleated polychromatic erythrocytes in mice administered doxorubicin.

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Samento: Plant Extracts with Anti-inflammatory Properties

Medicinal plants have long been used in traditional medicine for therapeutic purposes and their healing effects have well been recognized since ancient times. Geranium robertianum L. and Uncaria tomentosa (Willd.) DC. are medicinal plants with many therapeutic applications, being used in the treatment of antiinflammatory and anti-cancer diseases. G. robertianum L. belongs to the family of Geraniacea and is native from central and meridian Europe and Asia.

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Samento: Antioxident (hydrodynamic)

Uncaria tomentosa (Willd) D. C. (Rubiaceae) known as cat’s claw is a plant widely used in traditional Peruvian medicine to treat cancer and chemotherapy side effects among a wide range of other diseases (Obrego´n-Vilches, 1995). Research on this matter led to the discovery of pentacyclic monoterpenoid oxindole alkaloids (MOA) with immunomodulatory, cytotoxic, anti-AIDS, and anti-leukemic activities.

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Samento: Antioxidant (human)

The effect of ethanolic and aqueous extracts from leaves and bark of Uncaria tomentosa was studied, with particular attention to catalase activity (CAT – EC. We observed that all tested extracts, at a concentration of 250 lg/mL were not toxic to erythrocyte catalase because they did not decreased its activity. Additionally, we investigated the protective effect of extracts on changes in CAT activity in the erythrocytes incubated with sodium salt of 2,4-dichlorophenoxyacetic acid (2,4-D-Na) and its metabolites i.e., 2,4-dichlorophenol (2,4-DCP) and catechol.

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Samento: Antioxident (cat's claw)

Ozone (O3) inhalation has been associated with respiratory tract inflammation and lung functional alterations. To characterize the O3-induced lung inflammation in mice, the effective dose and exposure time were determined. Total protein levels of bronchoalveolar lavage fluid (BALF), cytological smears, and lung histopathology and morphometry were used to assess and measure the degree of pulmonary inflammation in the mouse model.

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Samento: Antineoplastic Effects.pdf

This study aimed to compare the anti-neoplastic effects of an Uncaria tomentosa (UT) brute hydroethanolic (BHE) extract with those of two fractions derived from it. These fractions are choroformic (CHCl3) and n-butanolic (BuOH), rich in pentacyclic oxindole alkaloids (POA) and antioxidant substances, respectively.

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Samento: Antimicrobial Activity

Endodontic therapy aims to remove diseased tissue, eliminate bacteria present in the canals and dentinal tubules, and prevent recontamination after treatment. These objectives are achieved by biomechanical cleaning and shaping of the root canal system, by sealing root canals with a 3-dimensional obturation, and by placing a coronal seal. Unfortunately, because of the anatomical complexity of the root canal system, organic and inorganic residues and bacteria cannot be completely removed and often persist.

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Samento: Antifungal In Vitro

Candida species are harmless saprophyte yeasts, a normal component of the human biota in the gastrointestinal tract and oral and vaginal mucosae. These yeasts can cause superficial infections manifested as thrush and vaginitis; excepting in immunecompromised and immune-suppressed patients, for instance, to whom they can cause severe systemic infections.

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Samento: Antifungal Activity

This study investigated in vitro antifungal activity of the hydroethanolic extract (EXT), quinovic acid glycosides (QAPF), oxindole alkaloids (OAPF), water-soluble (WSF) and insoluble fractions of polyphenols (WIF) obtained from Uncaria tomentosa bark against non-albicans Candida resistant isolates.

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Samento: Antibacterial Effect

The influence of water extract of Uncaria tomentosa (Willd.) DC. bark on Pseudomonas aeruginosa infection was studied. The preparation was obtained by extraction of bark Uncaria tomentosa with water (37°C, 24 h) and further fractionation. Inbred C57BL/6 mice 7-9 weeks old, ca 20 g of body mass, females, were fed water extract for 7 days (10, 20 or 100 mg/kg), or water (controls).

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Samento: Anti-inflammatory of Mitraphylline

Mitraphylline (MTP) is the major pentacyclic oxindolic alkaloid presented in Uncaria tomen­tosa. It has traditionally been used to treat disorders including arthritis, heart disease, cancer, and other inflammatory diseases. However, the specific role of MTP is still not clear, with more comprehensive stud­ies, our understanding of this ancient herbal medicine will continue growing.

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Samento: Antioxidant Properties

Decoctions prepared from the bark of Uncaria tomentosa (cats claw) are widely used in the traditional Peruvian medicine for the treatment of several diseases, in particular as a potent anti-inflammatory agent. Therefore, the main purpose of this study was to determine if the well-known anti-inflammatory activity of cats claw decoction was related with its reactivity with the oxidant species generated in the inflammatory process and to establish a relationship between such antioxidant ability and its phenolic composition.

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Samento: Anti-inflammatory activity of Mitraphylline

Uncaria tomentosa (Willd. ex Roem. & Schult.) DC. (Rubiaceae) is widely used by populations living in South America to treat many ailments associated with inflammatory disorders. Mitraphylline was shown to be the major pentacyclic oxindolic alkaloid present in the bark chloroformic extract of this plant. Its activity against cytokines involved in inflammation process was tested in a murine model in vivo.

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