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SPARGA

SULPHUR DETOX

FOR RESOLVING SULFITE AND SULFA DRUG TOXICITY

General Description

Sparga is an extract of the root of Asparagus officinalis and is used to resolve Sulfite and/or Sulfa drug toxicity.  This condition appears to block the efficient production of reduced L-glutathione, thus inhibiting the body's ability to eliminate toxins. The problem with sulfite and sulfa drugs likely results from a genetic up-regulation of the Cystathionine-Beta-Synthase (CBS) enzyme or a genetic down-regulation of Sulfite Oxidase (SuOx). When this occurs, sulfite and sulfa drugs build up in that individual, blocking glutathione production and blocking uptake of lipoic acid and sulfur amino acids thus making detoxification inefficient, in which case the toxins that are held up in the body weaken the immune system and the organs, and the patient is predisposed to chronic infection.  The CBS and/or SuOx genes may cause sulfites and sulfa drugs to build up to a high enough level in the body so as to possibly block the cell's ability to take up sulfur amino acids (cysteine, methionine, and taurine) as well as Glutathione and Lipoic Acid.  The absence of these nutrients in the cells can impair detoxification from the cells.

Some Reported Medicinal Properties

ANTI-ARTHRITIC

ANTI-DIABETIC

ANTI-INFLAMMATORY

ANTIOXIDANT

ANTI-RHEUMATIC

ANTI-TUMOR

ANTI-VIRAL

APHRODISIAC

CYTOTOXIC

DIURETIC

HEPATOPROTECTIVE

NEUROPROTECTIVE

SEDATIVE

Reasearch On Nutramedix Product

Medical Conditions [peer-reviewed journals]

Cancer                                               

Bousserouel, S., Le Grandois, J., Gossé, F., Werner, D., Barth, S. W., Marchioni, E., ... & Raul, F. (2013). Methanolic extract of white asparagus shoots activates TRAIL apoptotic death pathway in human cancer cells and inhibits colon carcinogenesis in a preclinical model. International Journal of Oncology, 43(2), 394-404. Full Article

Diabetes

Hafizur, R. M., Kabir, N., & Chishti, S. (2012). Asparagus officinalis extract controls blood glucose by improving insulin secretion and β-cell function in streptozotocin-induced type 2 diabetic rats. British Journal of Nutrition, 108(9), 1586-1595. Full Article

Tumor

Wang, J., Liu, Y., Zhao, J., Zhang, W., & Pang, X. (2013). Saponins extracted from by‐product of Asparagus officinalis L. suppress tumour cell migration and invasion through targeting Rho GTPase signalling pathway. Journal of the Science of Food and Agriculture, 93(6), 1492-1498. Full Article

Huang, X. F., Lin, Y. Y., & Kong, L. Y. (2008). Steroids from the roots of Asparagus officinalis and their cytotoxic activity. Journal of Integrative Plant Biology, 50(6), 717-722. Full Article

Medicinal Properties [peer-reviewed journals]

Antifungal

Wang, H., & Ng, T. B. (2001). Isolation of a novel deoxyribonuclease with antifungal activity from Asparagus officinalis seeds. Biochemical and Biophysical Research Communications, 289(1), 120-124. Full Article

Shimoyamada, M., Suzuki, M., Maruyama, M., & Watanabe, K. (1996). An antifungal saponin from white asparagus (Asparagus officinalis L) bottoms. Journal of the Science of Food and Agriculture, 72(4), 430-434. Full Article

Shimoyamada, M., Suzuki, M., Sonta, H., Maruyama, M., & Okubo, K. (1990). Antifungal activity of the saponin fraction obtained from Asparagus officinalis L. and its active principle. Agricultural and Biological Chemistry, 54(10), 2553-2557. Full Article

Antioxidant

Fan, R., Yuan, F., Wang, N., Gao, Y., & Huang, Y. (2015). Extraction and analysis of antioxidant compounds from the residues of Asparagus officinalis L. Journal of Food Science and Technology, 52(5), 2690-2700. Full Article

Lee, J. W., Lee, J. H., Yu, I. H., Gorinstein, S., Bae, J. H., & Ku, Y. G. (2014). Bioactive compounds, antioxidant and binding activities and spear yield of Asparagus officinalis L. Plant Foods for Human Nutrition, 69(2), 175-181. Full Article

Zhao, Q., Xie, B., Yan, J., Zhao, F., Xiao, J., Yao, L., ... & Huang, Y. (2012). In vitro antioxidant and antitumor activities of polysaccharides extracted from Asparagus officinalis. Carbohydrate Polymers, 87(1), 392-396. Full Article

Khorasani, A., Sani, W., Philip, K., Taha, R. M., & Rafat, A. (2010). Antioxidant and antibacterial activities of ethanolic extracts of Asparagus officinalis cv. Mary Washington: Comparison of in vivo and in vitro grown plant bioactivities. African Journal of Biotechnology, 9(49), 8460-8466. Full Article

Makris, D. P., & Rossiter, J. T. (2001). Domestic processing of onion bulbs (Allium cepa) and asparagus spears (Asparagus officinalis): effect on flavonol content and antioxidant status. Journal of Agricultural and Food Chemistry, 49(7), 3216-3222. Full Article

Ethonal metabolism

Kim, B. Y., Cui, Z. G., Lee, S. R., Kim, S. J., Kang, H. K., Effects of Asparagus officinalis extracts on liver cell toxicity and ethanol metabolism Lee, Y. K., & Park, D. B. (2009).. Journal of Food Science, 74(7), H204-H208. Full Article

Weight Loss

Zhu, X., Zhang, W., Pang, X., Wang, J., Zhao, J., & Qu, W. (2011). Hypolipidemic Effect of n‐Butanol Extract from Asparagus officinalis L. in Mice fed a High‐fat Diet. Phytotherapy Research, 25(8), 1119-1124. Full Article

Hepatoprotective

Zhu, X., Zhang, W., Zhao, J., Wang, J., & Qu, W. (2010). Hypolipidaemic and hepatoprotective effects of ethanolic and aqueous extracts from Asparagus officinalis L. by‐products in mice fed a high‐fat diet. Journal of the Science of Food and Agriculture, 90(7), 1129-1135. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video

Patient Reports

"I tried detoxes before, but my detox pathways were blocked.  After starting Sparga, the toxins were being eliminated quickly.  Sparga helped me recalibrate my whole body and my weight and joint pain dropped and my skin cleared up!  Sparga is really amazing!”  -O.N.

“I have used Sparga Sulphur Detox by NutraMedix for 10 months. Recommended by my MD to help with detoxifying from 9 months of daily IV treatments. Wonderful product. Love NutraMedix.” – A.N

“Sparga Sulphur Detox by NutaMedix helps so much for those of us fighting chronic illnesses! Can always count on this company!” – e A.P

“I used 10 drops 2x per day to lower my urine sulfate level and Sparga Sulphur Detox by NutraMedix has reduced my level in just 3 days.”  -P.S.

“I have Lyme disease that manifests as Rheumatoid arthritis.  The Asparagus extract does seem to help quite a bit.”  -P.U.

Dosage Information

10 drops twice daily for 3-4 months helps to resolve Sulfite and/or Sulfa drug toxicity.

Protocols

Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Sparga did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.

Product Label

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SPARGA
Sparga: Antioxidant

Ultrasonic circulating extractiontechnology was appliedfor thepolysaccharide extractionfromAsparagus officinalis. The crude polysaccharides were deproteinized by Sevag method and three main polysaccharide fractions, AOP-4, AOP-6 and AOP-8 were obtained by fractional precipitation with gradient concentrations of ethanol (40%, 60% and 80%).

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Sparga: Weight Loss

During industrial processing of Asparagus (Asparagus officinalis L.), around half of each spear is discarded. However, these discarded asparagus (by‐products) might be used as food supplements for their potential therapeutic effects.

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Sparga: Tumor

One new (Sarsasapogenin O) and seven known steroids were isolated from the roots of Asparagus officinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds.

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Sparga: Tumor (Saponins)

The global burden of cancer is still increasing and it is the leading cause of death in economically developed countries. About 12.7 million new cases and 7.6 million cancer deaths are estimated to have occurred in 2008 worldwide. Most cancers can be cured surgically before cancer metastasis, and 5 year survival rates are often above 90%.

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Sparga: Heptoprotective

Hyperlipidaemia, including hypercholesterolaemia and hypertriglyceridaemia, is a major risk factor in the development of cardiovascular diseases. Indeed, the Lipid Research Clinics Coronary Primary Prevention Trial has concluded that every 1% reduction in plasma total cholesterol (TC) leads to a 2% decrease in the risk of coronary heart disease.

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Sparga: Ethonal Metabolism

Asparagus officinalis is a vegetable that is widely consumed worldwide and has also long been used as a herbal medicine for the treatment of several diseases. Although A. officinalis is generally regarded as a supplement for the alleviation of alcohol hangover, little is known about its effects on cell metabolism.

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Sparga: Diabetes

Diet (nutrition) plays an important role in the management of diabetes, and for preventing and/or delaying the development of type 2 diabetes. Dietary approaches can be used alone (in the case of the onset of type 2 diabetes and in mild hyperglycaemia) or in combination with oral hypoglycaemic agents or insulin.

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Sparga: Antioxidant (Spear Yield)

The aim of this investigation was to find a proper harvesting period and establishing fern number, which effects the spear yield, bioactive compounds and antioxidant activities of Asparagus officinalis L. Spears were harvested at 2, 4, and 6 weeks after sprouting.

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Sparga: Antioxidant (onion)

Flavonols are of widespread occurrence in the most common edible fruits, vegetables, and seeds, and their content may reach up to a few hundred mg kg-1 of fresh weight. Berries such as bog whortleberry (Vaccinium uliginosum) and cranberry (Vaccinium oxycoccos) have been found to contain 184 and 263 mg kg-1 fresh weight of total flavonols, respectively.

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Sparga: Antioxidant (Mary)

Production of secondary metabolites using in vitro propagation techniques has been studied since the 1970s. For example, Al-Abta et al. (1979) showed that production of phthallides, the main flavour compounds of celery, can be detected in differentiated calli of celery plant but was undetected in the undifferentiated callus tissues. Based on several investigative studies, a compound produced in an in vivo plant could be produced at the same or different levels or not produced at all.

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Sparga: Antioxidant (Extraction)

Asparagus officinalis L., a well known healthy vegetable, which was named as “the king of vegetables” for its rich bioactive compounds, now is widely consumed all over the world. Bioactive components, such as flavonoid, lignan and steroidal saponin were found in this plant.

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Sparga: Antifungal

To date, many saponins have been isolated and characterized from asparagus. These constituents may have a bitter taste, and those parts which have a large amount of saponins in the 'bottom cut' must be discarded during processing.

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Sparga: Antifungal (Deoxy)

A deoxyribonuclease distinct from the previously isolated asparagus ribosome-inactivating proteins, possessing a molecular weight of 30 kDa and requiring a pH of 7.5 for optimum hydrolytic activity toward herring sperm DNA, was isolated from Asparagus officinalis seeds.

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Sparga: Antifungal (bottoms)

Asparagus is a familiar food as well as a medicinal plant in India and other countries. White asparagus is mostly processed into the canned product. For this purpose, the 'bottom cut' must be discarded because of its bitter taste, which is attributed to saponin constituents.

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Sparga: Cancer

Shoots of white asparagus are a popular vegetable dish, known to be rich in many bioactive phytochemicals reported to possess antioxidant, and anti-inflammatory and antitumor activities. We evaluated the anticancer mechanisms of a methanolic extract of Asparagus officinalis L. shoots (Asp) on human colon carcinoma cells (SW480) and their derived metastatic cells (SW620), and Asp chemopreventive properties were also assessed in a model of colon carcinogenesis.

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