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STEVIA

SWEET HERB

FOR RESOLVING BLOOD SUGAR REGULATION ISSUES; FOR USE AS A SWEETENER AND ANTIBACTERIAL

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General Description

Stevia is an extract from Stevia rebaudiana, having up to 300 times the sweetness of sugar. Stevia has garnered attention with the rise in demand for low-carbohydrate, low-sugar food alternatives. Nutramedix Stevia was identified as "Stevia A" in a study published in 2015 where it was shown to be more effective than doxycycline in eliminating Borreliaburgdorferi, in all morphologic forms. It also demonstrated a significant effect in eliminating B.burgdorferi biofilms which were exacerbated when using doxycycline.

Some Reported Medicinal Properties

ANTI-ACNE

ANTI-BACTERIAL

ANTI-CANDIDIASIS

ANTI-DANDRUFF

ANTI-DERMATITIS

ANTI-DIABETES

ANTI-CYSTITIS

ANTI-DYSPEPTIC

ANTI-GINGIVITIS

ANTI-HEARTBURN

ANTI-INFLAMMATORY BOWEL DISEASE

ANTI-NEPHROPATHY

ANTI-OBESITY

ANTI-OSTEOPOROTIC

ANTIOXIDANT

ANTI-RASH

ANTISEPTIC

ANTI-TOOTH DECAY

ANTI-TUMOR

DIURETIC

HYPOGLYCEMIC

HYPOTENSIVE

NATRIURETIC

PRO-ENERGY

Reasearch On Nutramedix Product

In vitro – Lyme disease

Priyanka A.S. Theophilus M.S., Eva Sapi Ph.D. (2013). In Vitro Effect of Peruvian Antimicrobial Agents on Borrelia burgdorferi Full Article

IN VIVO ACUTE ORAL TOXICITY TESTS

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Stevia did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

LYME

Theophilus, P. A. S., Victoria, M. J., Socarras, K. M., Filush, K. R., Gupta, K., Luecke, D. F., & Sapi, E. (2015). Effectiveness of Stevia rebaudiana whole leaf extract against the various morphological forms of Borrelia burgdorferi in vitro. European Journal of Microbiology and Immunology, 5(4), 268-280. Full Article

Medical Conditions [peer-reviewed journals]

Human Rotavirus (HRV)

Takahashi, K., Matsuda, M., Ohashi, K., Taniguchi, K., Nakagomi, O., Abe, Y., ... & Shigeta, S. (2001). Analysis of anti-rotavirus activity of extract from Stevia rebaudiana. Antiviral research, 49(1), 15-24. Full Article

DIABETES

Ahmad, U., & Ahmad,R. S. (2018). Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino ratsBMC complementary and alternative medicine18(1),179. Full Article

Carrera-Lanestosa, A.,Moguel-Ordóñez, Y., & Segura-Campos, M. (2017). Stevia rebaudiana Bertoni: a natural alternative for treating diseases associated with metabolic syndrome. Journal of medicinal food, 20(10), 933-943. Full Article

AbdElwahab, A. H.,Yousuf, A. F., Ramadan, B. K., & Elimam, H. (2017). Comparative Effects of Stevia rebaudiana and Aspartame on hepato-renal function of diabetic rats: Biochemical and Histological Approaches. Journal of Applied Pharmaceutical Science Vol, 7(08), 034-042. Full Article

Patil, A., Nirmal, S.,Pattan, S., Tambe, V., & Tare, M. (2012). Antidiabetic effect of polyherbal combinations in STZ induced diabetes involve inhibition of α-amylase and α-glucosidase with amelioration of lipid profile. Phytopharmacology, 2(1), 46-57. Full Article

Pallarés, Á., Carrasco,G., Nava, Y., Pallarés, O., Pérez, I., Rifá, R., & Rodríguez, M. (2015). Effectiveness and safety of Stevia rebaudiana dried leaves as an adjuvant in the short-term treatment of type 2 diabetes: A randomized, controlled, cross-over and double-blinded trial. JMed Plant Herbal Ther Res, 3, 16-26. Full Article

Ruiz-Ruiz, J. C.,Moguel-Ordoñez, Y. B., Matus-Basto, A. J., & Segura-Campos, M. R. (2015). Antidiabetic and antioxidant activity of Stevia rebaudiana extracts (Var. Morita) and their incorporation into a potential functional bread. Journal of food science and technology, 52(12),7894-7903. Full Article

Parimalavalli, R.,& Radhaisri, S. (2011). Glycaemic index of stevia product and its efficacy on blood glucose level in type 2 diabetes. Indian Journal of Science and Technology, 4(3), 318-321. Full Article

Sharma, R., Yadav, R.,& Manivannan, E. (2012). Study of effect of Stevia rebaudiana bertoni on oxidative stress in type-2 diabetic rat models. Biomedicine & Aging Pathology, 2(3), 126-131. Full Article

Maki, K. C., Curry, L.L., Reeves, M. S., Toth, P. D., McKenney, J. M., Farmer, M. V., ... & Carakostas, M. C. (2008). Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus. Food and Chemical Toxicology, 46(7), S47-S53. Full Article

Sumon, M. H., Mostofa,M., Jahan, M. S., Kayesh, M. E. H., & Haque, M. A. (2008). Comparative efficacy of powdered form of stevia (Stevia rebaudiana Bertoni) leaves and glimepiride in induced diabetic rats. Bangl. J. Vet. Med, 6(2), 211-215. Full Article

Dyrskog, S. E. U.,Jeppesen, P. B., Colombo, M., Abudula, R., & Hermansen, K. (2005). Preventive effects of a soy-based diet supplemented with stevioside on the development of the metabolic syndrome and type 2 diabetes in Zucker diabetic fatty rats. Metabolism, 54(9),1181-1188. Full Article

Giri, A., Rao, H. R.,& Ramesh, V. (2014). Effect of partial replacement of sugar with stevia on the quality of kulfi. Journal of food science and technology, 51(8), 1612-1616. Full Article

Ozbayer, C., Kurt, H.,Kalender, S., Ozden, H., Gunes, H. V., Basaran, A., ... & Degirmenci, I.(2011). Effects of Stevia rebaudiana (Bertoni) extract and N-nitro-L-arginine on renal function and ultrastructure of kidney cells in experimental type 2 Diabetes. Journal of medicinal food, 14(10), 1215-1222. Full Article

Anton, S. D., Martin,C. K., Han, H., Coulon, S., Cefalu, W. T., Geiselman, P., & Williamson, D.A. (2010). Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels. Appetite, 55(1), 37-43. Full Article

Assaei, R., Mokarram,P., Dastghaib, S., Darbandi, S., Darbandi, M., Zal, F., ... & Omrani, G. H.R. (2016). Hypoglycemic effect of aquatic extract of stevia in pancreas of diabetic rats: PPARγ-dependent regulation or antioxidant potential. Avicenna journal of medical biotechnology, 8(2), 65. Full Article

Gupta, E., Purwar, S.,Sundaram, S., & Rai, G. K. (2013). Nutritional and therapeutic values of Stevia rebaudiana: A review. Journal of Medicinal Plants Research, 7(46), 3343-3353. Full Article

Shivanna, N., Naika,M., Khanum, F., & Kaul, V. K. (2013). Antioxidant, anti-diabetic and renal protective properties of Stevia rebaudiana. Journal of Diabetes and its Complications, 27(2), 103-113. Full Article

Kujur, R. S., Singh,V., Ram, M., Yadava, H. N., Singh, K. K., Kumari, S., & Roy, B. K. (2010). Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats. Pharmacognosy research, 2(4), 258. Full Article

Ritu, M., & Nandini, J. (2016). Nutritional composition of Stevia rebaudiana, a sweet herb, and its hypoglycaemic and hypolipidaemic effect on patients with non‐insulin dependent diabetes mellitus. Journal of the Science of Food and Agriculture, 96(12), 4231-4234. Full Article

Laribi, B., Rouatbi,N., Kouki, K., & Bettaieb, T. (2012). In vitro propagation of Stevia rebaudiana (Bert.)-A non-caloric sweetener and antidiabetic medicinal plant. Int. J. Med. Arom. Plants, 2(2), 333-339. Full Article

Mohd-Radzman, N. H.,Ismail, W. I. W., Adam, Z., Jaapar, S. S., & Adam, A. (2013). Potential roles of Stevia rebaudiana Bertoni in abrogating insulin resistance and diabetes: a review. Evidence-Based Complementary and Alternative Medicine, 2013. Full Article

Jeppesen, P. B.,Gregersen, S., Poulsen, C. R., & Hermansen, K. (2000). Stevioside acts directly on pancreatic β cells to secrete insulin: Actions independent of cyclic adenosine monophosphate and adenosine triphosphate—sensitive K+-channel activity. Metabolism, 49(2), 208-214. Full Article

Medicinal Properties [peer-reviewed journals]

Antibacterial

Fazal, H. I. N. A., Ahmad, N., Ullah, I., Inayat, H., Khan, L., & Abbasi, B. H. (2011). Antibacterial potential in Parthenium hysterophorus, Stevia rebaudiana and Ginkgo biloba. Pak. J. Bot, 43(2), 1307-1313. Full Article

Antidiabetic

Kujur, R. S., Singh, V., Ram, M., Yadava, H. N., Singh, K. K., Kumari, S., & Roy, B. K. (2010). Antidiabetic activity and phytochemical screening of crude extract of Stevia rebaudiana in alloxan-induced diabetic rats. Pharmacognosy research, 2(4), 258. Full Article

Antimicrobial

Ghosh, S., Subudhi, E., & Nayak, S. (2008). Antimicrobial assay of Stevia rebaudiana Bertoni leaf extracts against 10 pathogens. Int J Integr Biol, 2(1), 1-5. Full Article

Jayaraman, S., Manoharan, M. S., & Illanchezian, S. (2008). In-vitro antimicrobial and antitumor activities of Stevia rebaudiana (Asteraceae) leaf extracts. Tropical Journal of Pharmaceutical Research, 7(4), 1143-1149. Full Article

Debnath, M. (2007). Clonal propagation and antimicrobial activity of an endemic medicinal plant Stevia rebaudiana. Journal of medicinal plants research, 2(2), 045-051. Full Article

Tadhani, M. B., & Subhash, R. (2006). In vitro antimicrobial activity of Stevia rebaudiana Bertoni leaves. Tropical Journal of Pharmaceutical Research, 5(1), 557-560. Full Article

Antioxidant

Barba, F. J., Criado, M. N., Belda-Galbis, C. M., Esteve, M. J., & Rodrigo, D. (2014). Stevia rebaudiana Bertoni as a natural antioxidant/antimicrobial for high pressure processed fruit extract: Processing parameter optimization. Food Chemistry, 148, 261-267. Full Article

Shukla, S., Mehta, A., Mehta, P., & Bajpai, V. K. (2012). Antioxidant ability and total phenolic content of aqueous leaf extract of Stevia rebaudiana Bert. Experimental and Toxicologic Pathology, 64(7-8), 807-811. Full Article

Kim, I. S., Yang, M., Lee, O. H., & Kang, S. N. (2011). The antioxidant activity and the bioactive compound content of Stevia rebaudiana water extracts. LWT-Food Science and Technology, 44(5), 1328-1332. Full Article

Shukla, S., Mehta, A., Bajpai, V. K., & Shukla, S. (2009). In vitro antioxidant activity and total phenolic content of ethanolic leaf extract of Stevia rebaudiana Bert. Food and Chemical Toxicology, 47(9), 2338-2343 Full Article

Tadhani, M. B., Patel, V. H., & Subhash, R. (2007). In vitro antioxidant activities of Stevia rebaudiana leaves and callus. Journal of food composition and Analysis, 20(3-4), 323-329. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video

Patient Reports

“Has a great sweet taste, I use this for my Lyme disease, and I did herx on it at first, so I had to back off a little, but it works fine, and since its best for me to stay away from sugar, it’s a great sweetener, i put in my water with a squeeze of lemon. love it.” - A.S

“I have to take a few antimicrobials for a bacterial infection, and this stevia definitely improves the taste!” – K.L

“Curbs sugar craving. Excellent for anyone with Lyme disease or a that's looking for a good quality extract.” – M.L

"I've been addicted to sugar since I was 5.  My doctor told me that I was going into pre-diabetes and that I better make a change.  He told me about NutraMedix Stevia – that it wasn't a fractured, processed version of the Stevia plant.  He said that it came from the plant as a whole food and that's been my goal ever since – to get healthy by eating whole foods and no sugar.  I'm proud to say I've lost 50 pounds and I no longer crave sugar.  This Stevia is really good."  -R.M.

Dosage Information

Add 3 or more drops as desired to food or beverages.  As an antimicrobial, use 30 drops twice daily. Nutramedix Stevia contains no added sugars.

Protocols

Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Stevia did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

Product Label

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Search Link
STEVIA
Stevia: Diabetes (nutritional)

Stevia rebaudiana is a nutrient rich natural sweetest plant of Asteraceae family. The leaves naturally contain diterpene glycosides stevioside, rebaudiosides A-F, steviolbioside and dulcoside, which are responsible for its sweet taste and have commercial value all over the world as sugar substitute in foods, beverages or medicines.

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Stevia: Diabetes (In vitro propagation)

Research on medicinal plants has considerably increased in recent years and is nowadays oriented towards discovering new sources beneficial to human health. Naturally low calorie sweeteners isolated from medicinal plants are gaining a great interest in their use as dietary sucrose substitutes in food and pharmaceutical products.

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Stevia: Diabetes (effectiveness)

A randomized, controlled, cross-over and double-blinded study was conducted to assess the effectiveness and safety of Stevia rebaudiana leaves to reduce blood glucose and mean arterial pressure in Sahrawi patients with type 2 diabetes.

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Stevia: Diabetes (Comparative Effects of Stevia)

Diabetes mellitus is a chronic syndrome affecting many systems of the body and may be considered as a leading cause of death globally. To compare the efficacy of Stevia rebaudiana and Aspartame on hepato-renal functions, sixty adult male albino rats were divided into 6 groups; control, Stevia, Aspartame, diabetic, diabetic-treated with Stevia and diabetic-treated with Aspartame.

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Stevia: Diabetes (Comparative efficacy)

Now a day, various medicinal plants are becoming popular for the treatment of different diseases. Some medicinal plants are being used for the treatment of diabetes all over the world. The study was conducted to investigate the effects of powdered form of Stevia (Stevia rebaudiana Bertoni) leaves on blood glucose concentration and body weight in Streptozotocin induced diabetic rats and for its efficacy study with a patent drug, Glimepiride.

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Stevia: Diabetes (antidiabetic)

The concerned study reveals antidiabetic effects of different polyherbal combinations of six medicinal plants used in traditional medicine. Aim of the present study was to evaluate antidiabetic action of polyherbal combination of six medicinal plants.

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Stevia: anti-rotavirus

Anti-human rotavirus (HRV) activity of hot water extracts from Stevia rebaudiana (SE) was examined. SE inhibited the replication of all four serotypes of HRV in vitro. This inhibitory effect of SE was not reduced on the prior exposure of SE to HCl for 30 min at pH 2.

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Stevia: Antioxidant (bioactive)

Stevia rebaudiana (SR), a chrysanthemum herb, has been used as a vegetable-based sweetening additive in health drinks and in other foods. This study was conducted to investigate the antioxidant activity and the bioactive compounds found in water extracts taken from SR leaves and calli.

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Stevia: Antioxidant (diterpene)

Steviol glycosides are currently being used as natural sweeteners by the food industry and Stevia rebaudiana has long been used as a sweet plant in South America for patients suffering from diabetes. In this study, a Stevia rebaudiana ethanolic extract (SREE) was prepared, analysed and tested for antioxidant activity in terms of free radical scavenging properties and antiproliferative effects in cervix (HeLa), pancreatic (MiaPaCa-2) and colonic (HCT116) cancer cells.

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Stevia: Antimicrobial (tumor)

There is a continuous and urgent need to discover new antimicrobial compounds with diverse chemical structures and novel mechanisms of action due to an alarming increase in the incidence of new and reemerging infectious diseases and development of resistance to the antibiotics in current clinical use. The screening of plant extracts has been of great interest to scientists in the search for new drugs for greater effective treatment of several diseases. Therefore, plant extracts and phytochemicals with known antimicrobial properties can be of great significance in therapeutic treatments.

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Stevia: Antimicrobial (clonal)

A procedure has been outlined for plant regeneration and antimicrobial screening of a medicinal herb, Stevia rebaudiana Bertoni, through in vitro culture of nodal segments with axillary buds.

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Stevia: Antimicrobial (bertoni)

Purpose: The aim of the present study was to investigate antimicrobial activity of the various extracts of Stevia rebaudiana leaves.

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Stevia: Antimicrobial (10 pat)

With an objective of understanding the antimicrobial potential of Stevia rebaudiana (popularly called as Stevia and synonymously known as ‘sugar substitute’ belongs to family Asteraceae), chemical extracts from its leaves were subjected to microbial assay using six solvents against ten selected pathogenic as well as food spoiling fungal (Alternaria solani, Helminthosporium solani, Aspergillus niger, Penicillium chrysogenum) and pathogenic bacterial (Escherichia coli, Bacillus subtilis, Enterococcus faecalis, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus) isolates.

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Stevia: Antidiabetic

Stevia rebaudiana regulates blood sugar, prevents hypertension and tooth decay. Other studies have shown that it has antibacterial as well as antiviral property.

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Stevia: Antibacterial

Plants produce a diverse range of bioactive molecules, making them rich source of different types of medicines. Most of the drugs today are obtained from natural sources or semi synthetic derivatives of natural products and used in the traditional systems of medicine.

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Stevia: Toxicity Study (English Translated)

Objectives: To study adverse side effects produced by the administration of STEVIA on body weight and different body systems.

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Stevia: Lyme Disease

Lyme disease is a tick-borne multisystemic disease caused by Borrelia burgdorferi. Administering antibiotics is the primary treatment for this disease; however, relapse often occurs when antibiotic treatment is discontinued. The reason for relapse remains unknown, but recent studies suggested the possibilities of the presence of antibiotic resistant Borrelia persister cells and biofilms.

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Stevia: Antioxidant Ability

In the present study, we carried out a systematic research on relative antioxidant activity of aqueous leaf extract of Stevia rebaudiana. The DPPH activity of aqueous leaf extract (20, 40, 50, 100 and 200 g/ml) was increased in a dose dependent manner, which was found in the range of 40.00–72.37% as compared to ascorbic acid 64.26–82.58%.

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Stevia: Antioxidant Activity

The aim of this study was to assess the in vitro potential of ethanolic leaf extract of Stevia rebaudiana as a natural antioxidant. The DPPH activity of the extract (20, 40, 50, 100 and 200 lg/ml) was increased in a dose dependent manner, which was found in the range of 36.93–68.76% as compared to ascorbic acid 64.26–82.58%.

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Stevia: Antioxidant Activities

Leaf extract of Stevia rebaudiana promotes effects on certain physiological systems such as the cardiovascular and renal and influences hypertension and hyperglycemia. Since these activities may be correlated with the presence of antioxidant compounds, leaf and callus extracts of Stevia rebaudiana were evaluated for their total phenols, flavonoids content and total antioxidant capacity.

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Stevia: Anti-rotavirus Activity

Anti-human rotavirus (HRV) activity of hot water extracts from Stevia rebaudiana (SE) was examined. SE inhibited the replication of all four serotypes of HRV in vitro. This inhibitory effect of SE was not reduced on the prior exposure of SE to HCl for 30 min at pH 2. Binding assay with radiolabeled purified viruses indicated that the inhibitory mechanism of SE is the blockade of virus binding.

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