STEVIA

Conjugates of the antituberculosis drug isoniazid (isonicotinyl hydrazine) and isomeric hydrazides of nicotinic and αpicolinic acid with glycoside steviolbioside from the Stevia rebaudiana plant and the product of its acid hydrolysis, diterpenoid isosteviol, were synthesized.

About 100 metabolites of various structures (lipids, phenols, quinones, peptides, alkaloids, terpenoids, steroids, glycosides) that inhibit the growth of Mycobacterium tuberculosis have currently been isolated from natural plant sources [1–4].

Stevia rebaudiana Bertoni is a perennial shrub with zero calorie content that has been increasing in popularity for its potential use as an adjuvant in the treatment of obesity. We conducted a review of the literature summarizing the current knowledge and role in human disease.

Stevia rebaudiana (SR) is often used by the food industry due to its steviol glycoside content, which is a suitable calorie-free sweetener. Further, both in vitro and in vivo studies indicate that these glycosides and the extracts from SR have pharmacological and therapeutic properties, including antioxidant, antimicrobial, antihypertensive, antidiabetic, and anticancer.

The antiviral potential of natural polysaccharide compounds has been demonstrated, especially against enveloped viruses and members of the Herpesviridae family.

Stevia rebaudiana (Bert.) Bertoni besides being a source of noncaloric sweeteners is also an important source of bioactive molecules. Many plant extracts, mostly obtained with ethyl acetate solvent, are rich in polyphenol compounds that present insulinotropic effects.

Apart from being well known to the world as herb-based sweetening additive, Stevia rebaudiana (S. rebaudiana) and its phenolic compounds are considered as a natural antidiabetic alternative to replace synthetic drugs that possess numbers of side effects.

The biological activity of a dried, purified extract of Stevia leaves was assessed using a modified method [6, 7] to test antiviral activity in collaboration with the All-Russian Science Research Institute of Veterinary Virology and Microbiology (VNIIBBiM).

Stevia (Stevia rebaudiana Bert.) is a relevant source of natural phenolic compounds with antioxidant and antimicrobial properties. The aim of this study was to evaluate the potential protective effect of crude stevia extracts on the quality and shelf-life of salmon (Salmo salar) paste.

Stevia leaf powder (SLP) and a commercial stevioside powder (CSP) were analysed for their polyphenol content, isothermal sorption behavior and their antioxidant activity was evaluated by DPPH radical scavenging activity, ferric reducing power and ABTS assay.

The screening of plant extract has been of great interest to scientists in the search for new drugs for greater effective treatment of several diseases[1]. Stevia rebaudiana (S. rebaudiana), a natural alternative to artificial sweetener is found to contain over 100 phytochemicals including well characterized stevioside and rebaudioside.

Stevia rebaudiana is a nutrient rich natural sweetest plant of Asteraceae family. The leaves naturally contain diterpene glycosides stevioside, rebaudiosides A-F, steviolbioside and dulcoside, which are responsible for its sweet taste and have commercial value all over the world as sugar substitute in foods, beverages or medicines

The main component of the glycosides from the plant Stevia rebaudiana Bertoni, the glycoside stevioside (I), which is used as a food sweetener [1], has hypotensive [2], insulinotropic, and antihyperglycemic [3] properties.

Generally, the fungal infections are the most common cause of many skin diseases in developing countries [1]. Opportunistic fungal infections, mainly resulting from the species of Candida, Cryptococcus and Aspergillus are life-threatening in immunocompromised patients (with AIDS, cancer, or organ transplant).

Stevia rebaudiana is considered natural as source of antioxidants, which contained phenolic compounds and flavonoides at levels 24.01 and 18.93 mg/g dry weight basis of leaves and 33.99 and 30.03 mg/g dry weight basis of callus, these substances have been suggested to play a preventive role for human health.

Essential oil (EO), water extract (WE), and methanole water (MWE) (50/50 v:v) were prepared from Stevia rebaudiana Bertoni leaves. Their chemicals compounds, antioxidant, anti-inflammation and antimicrobial activities were evaluated.

Stevia rebaudiana is a name that prevails in the medicinal world from the times of Ayurveda. It is a plant having applications in multifarious fields. It is commercially well known and has become an interesting area of research these days.

Stevia a „Latin American herb‟ is the world‟s only natural sweetener with zero calories, zero carbohydrates and a zero glycemic index. In the present investigation, the in vitro regeneration of Stevia rebaudiana was performed through callogenesis and organogenesis from different explants (Leaves, Inter node, Shoot discs).

Stevia rebaudiana Bertoni is a plant species in the genus Stevia of the sunflower family (Asteraceae), commonly known as candy leaf, sweet leaf, or sugar leaf. It has annual, subligneous, more or less pubescent stems with extensive, fibrous and filiform root system.

Ethanolic extract of bitter fraction of Stevia rebaudiana (Srbf) was extracted to investigate its antihyperglycemic and protective effects on renal structural changes in STZ-induced diabetes.

Stevia and its glycosides are becoming more popular both in the world of science and in the food industry. This review discusses the functional properties of Stevia, which is mainly used as an alternative sweetener.

Diabetes mellitus is a persistent disorder and is a universal chief cause of poor health. It is highlighted by hyperglycemia along with carbohydrate, protein and fat metabolisms.

Some extracts of medicinal plants have been proven to be beneficial in treating a number of diseases for centuries such as treating diabetes, antioxidant, anti-inflammatory, antibacterial, etc.

Recently, non nutritive sweeteners that can substitute for sucrose (high in calorie) cause increased the prevalence of overweight children and adults. Non-caloric or low caloric sweeteners as tools for making healthful food choices have been introduced to satisfy consumer demand.

Stevia rebaudiana (Bertoni), a perennial shrub, is the sweetest plant belonging to the Asteraceae family. Stevia leaves are an excellent source of diterpene glycosides stevioside, rebaudioside A-F, dulcoside, and steviolbioside, whichare responsible for sweetness and have been utilized commercially for sugar substitution in foods, beverages, and medicines.

Stevia rebaudiana (SR) is often used by the food industry due to its steviol glycoside content, which is a suitable calorie-free sweetener. Further, both in vitro and in vivo studies indicate that these glycosides and the extracts from SR have pharmacological and therapeutic properties, including antioxidant, antimicrobial, antihypertensive, antidiabetic, and anticancer.

Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus. In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other than diabetes.

Stevia rebaudiana Bertoni has been used for the treatment of diabetes in, for example, Brazil, although a positive effect on antidiabetic and its complications has not been unequivocally demonstrated. This herb also has numerous therapeutic properties which have been proven safe and effective over hundreds of years. Streptozotocin is a potential source of oxidative stress that induces genotoxicity.

The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. India shelters the highest number of diabetics and is thus known as the ‘Diabetes Capital of the World’. The chemical management of diabetes has side\ effects and hence the present study was undertaken to assess the hypoglycaemic and hypolipidaemic effect of Stevia rebaudiana in patients with type 2 diabetes, non-insulin dependent diabetes mellitus (NIDDM). Its nutritional composition and use as a sweetener substitute were also assessed.

Consumption of sugar-sweetened beverages may be one of the dietary causes of metabolic disorders, such as obesity. Therefore, substituting sugar with low calorie sweeteners may be an efficacious weight management strategy. We tested the effect of preloads containing stevia, aspartame, or sucrose on food intake, satiety, and postprandial glucose and insulin levels.

Diabetes is the leading cause of chronic renal failure. Our purpose was to determine the effects of N-nitro-L­arginine (L-NNA) and an extract of Stevia rebaudiana (Bertoni) (SrB) leaves on renal function in streptozotocin-nicotinamide (STZ-NA)-induced diabetic rats.

Stevia is a natural sweetener obtained from the leaf of Stevia rebaudiana plant. Its refined extract powder is 130–300 times sweeter than sucrose. Besides, it prevents diabetes,decreases weight, prevents tooth decay, increases digestion etc.

The world witnesses an explosive increase in diabetes, demanding intensified prevention and treatment not least for the low-income population. The plant,Stevia rebaudiana Bertoni, has been used for the treatment of diabetes in traditional medicine. We have previously demonstrated that stevioside, a diterpene glycoside isolated from the plant Stevia rebaudiana Bertoni, possesses insulinotropic,glucagonostatic, antihyperglycemic, and blood pressure–lowering effects in animal studies.

A clinical condition “Diabetes” is more often associated with the release of a massive amount of toxic free radicals, which significantly decrease the level of antioxidant enzymes, increase lipid peroxidation, and worsen the disease state by causing further hyperglycemia. Many plant extracts and plant-derived natural compounds have been reported to possess antioxidant activities, and useful in preventing the deleterious effects of oxidative stress.

Stevia, a fantastic zero calorie sweetener, an incredible internal medicine, also products made from whole leaf concentrate have extra ordinary health benefits. The GI of foods has potential implications for the prevention and treatment of major chronic diseases, including diabetes, CHD and obesity. The objectives of the study were to determine the glycaemic index of chappathi with stevia leaf powder and to find out the therapeutic efficacy of chappathi with stevia extract on blood glucose level of women with type 2 diabetes.

The natural sweetener stevioside, which is found in the plant Stevia rebaudiana Bertoni, has been used for many years in the treatment of diabetes among Indians in Paraguay and Brazil. However, the mechanism for the blood glucose-lowering effect remains unknown. To elucidate the impact of stevioside and its aglucon steviol on insulin release from normal mouse islets and the ~-cell line INS-1 were used.

Apart from being well known to the world as herb-based sweetening additive,Stevia rebaudiana (S.rebaudiana)and its phenolic compounds are considered as a natural antidiabetic alternative to replace synthetic drugs that possess numbers of side effects. Therefore, this study was aimed to evaluate the solvent effects on the extraction of phenolic compounds and steviol glycoside identification associated with antidiabetic potential of the extracts.

In this study a new wheat bread was designed whose sugars were replaced with S. rebaudiana Bertoni aqueous extract. The impact of the S. rebaudiana Bertoni aqueous extract on nutritional and sensory quality, its ability to reduce sugar intake and its antioxidant properties were investigated.Functional bread with 50 % of sugars replaced with S. rebaudiana extract was compared with traditional wheatbread.

It is important to understand the mechanism of cadmium (Cd) toxicity and its potential risk to the health of a population exposed to Cd occupationally or environmentally. Kidneys inefficiently excrete Cd after prolonged intake and damage to the nephrons occurs, seriously affecting kidney functions. Rats treated with Stevia rebaudiana leaf extract could withstand Cd administered at a dosage of 6 mg/kg of body weight for 30 days.

Stevia is a genus of approx. 200 species of herbs and shrubs from the family Astraceae. One of the representatives of the genus is sweetleaf Stevia rebaudiana, formerly called Eupatorium rebaudianum Bertoni (Yadav et al. in Can J Plant Sci 91:1–27, 2011).

Stevioside is a natural plant glycoside isolated from the plant Stevia rebaudiana which has been commercialized as a sweetener in Japan for more than 20 years. Previous animal studies have shown that stevioside has an antihypertensive effect. This study was to designed to evaluate the effect of stevioside in human hypertension.

Consumption of sucrose is one of the dietary origins of some health concerns, such as dental caries, obesity and diabetes type 2. In Morocco, the statistics are alarming. Therefore, in order to reduce these major and growing problems of society, substituting sugar with low calorie sweeteners may be effective.

Traditional medicines with anti-diabetic effects are considered suitable supplements to treat diabetes. Among medicinal herbs, Stevia Rebaudiana Bertoni is famous for its sweet taste and beneficial effect in regulation of glucose. However, little is known about the exact mechanism of stevia in pancreatic tissue. Therefore, this study investigated the possible effects of stevia on pancreas in managing hyperglycemia seen in streptozotocin-induced Sprague-Dawley rats.

The purpose of the present study was to compare the effect of the oral treatment (gavage) with Stevia rebaudiana (Bert.) Bertoni (SRB) and stevioside (STV) on glycaemia and gluconeogenesis of 15-h fasted rats. For this purpose, the rats received SRB (20 mg/kg x day), STV (5.5 mg/kg x day) or an equal volume of water (controls) during 15 days.

We live in an age of modern convenience and great advancement but mankind's ongoing battle with health disorders shows no signs of diminishing. These are the results of the fast urban artificial lifestyle, changing diet patterns, lack of exercise, stress etc which are responsible for making many in developing countries susceptible to obesity related health problems like diabetes, dyslipidemia, heart disease, hypertension, stroke etc.

Now a days, various medicinal plants are becoming popular for the treatment of different diseases. Some medicinal plants are being used for the treatment of diabetes all over the world. The study was conducted to investigate the effects of powdered form of Stevia (Stevia rebaudiana Bertoni) leaves on blood glucose concentration and body weight in Streptozotocin induced diabetic rats and for its efficacy study with a patent drug, Glimepiride.

The aim of our study was to determine the antioxidant activities, cytotoxicity and proliferative properties in Stevia rebaudiana leaves and stems. Leaves extracts exhibited a higher antioxidant activity than stems extract, through oxygen radical absorbance capacity (ORAC) and cellularantioxidant activity (CAA) assays.

The current research was carried out to explore the anti-diabetic effect of aqueous extract of Stevia rebaudiana leaves in albino rats. For this purpose, diabetes was induced by administration of streptozotocin (40 mg/kg body weight, intraperitoneally). The diabetic rats were administered with aqueous stevia extract at different dose levels (200, 300, 400 and 500 ppm/kg b.w) for 8 weeks; the control rats were fed basal diet during this period.

Stevia is dried roots and leaves of Stevia rebaudiana, Family-Asteraceae, native to Paraguay and Brazil. It is commonly known as sweet leaf of Paraguay, honey leaf, candy leaf etc.

Stevia, Stevia rebaudiana (Bertoni), has become an important economic plant for its commercial use as a sweetener. Stevia plays a significant role in the healthcare practice of different cultures and in population.

The leaves of Stevia rebaudiana Bertoni has nutrients and phytochemicals, which make it an adequate source for the extraction and production of functional food ingredients. Preclinical and clinical studies suggest therapeutic and pharmacological applications for stevia and their extracts because they are not toxic and exhibit several biological activities

Plants have always been an exemplary source of drugs and many of the currently available medicines have been directly or indirectly derived from them. For this reason, the research, development and use of natural products as therapeutic agents, especially those derived from plants, have been increasing in recent years.

Stevia rebaudiana (Bertoni) Bertoni (Compositae) is a perennial native shrub from north-eastern Paraguay and southern Brazil (Geuns, 2002).The leaves of Stevia rebaudiana (Bertoni) Bertoni have been used by Guarani Indians from Paraguay to treat diabetes and this empirical knowledge was passed by oral tradition for many centuries (Bazotte et al.,1986).

Stevia is the new emerging alternative source of calorie free sweetener having no carbohydrate and fat.It is 20 to 30 times sweet than cane and beet sugar, highly nutritious, delicious, non-toxic and non-additive sugar. It also enhances the flavour, helpful in digestion, weight reduction, anti oxidant, prevent dental caries and having antimicrobial and anti-plaque properties, increases mental alertness, increase energy levels but does not affect the blood sugar level, therefore key-source sweetener for diabetic world.

A high potency low calorie bio-sweetener “Stevia” has been grown in many countries around the globe for its sweetening and health promoting properties. Besides of making the world a sweeter place, stevia is well known for its efficient therapeutic and pharmacological agents.

Stevia rebaudiana (Bertoni), a perennial shrub, is the sweetest plant belonging to the Asteraceae family. Stevia leaves are an excellent source of diterpene glycosides stevioside, rebaudioside A-F, dulcoside, and steviolbioside, which are responsible for sweetness and have been utilized commercially for sugar substitution in foods, beverages, and medicines.

The main source of sugar has for long been cane sugar with beet sugar contributing a small percentage. These sugars along with sweetening qualities also have been found to contribute calories, which can lead to obesity, a risk factor for some chronic diseases such as Diabetes mellitus, Hypertension, Cardiovascular diseases, etc.

Diabetes mellitus (DM) is a serious worldwide problem related to human hyperglycemia. Thus, herbal preparations with antihyperglycemic properties especially leaf extracts of hydroponic Stevia rebaudiana (SR) would be useful in hyperglycemia treatment.

Stevia (Stevia rebaudiana Bertoni) natural, safe, non-toxic, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of hyperlipidemia.

The application of edible plants with more effective ability to inhibit fat digestion and absorption has recently been explored foi: possible treatment of hyperlipidaemia. The aim of the present study is to investigate the effect of nine edible plants on the inhibition of pancreatic lipase and pancreatic cholesterol esterase activities, as well as the inhibition of cholesterol micelle formation, and bile acid binding

The prevalence of diabetes is rapidly rising all over the globe at an alarming rate. India shelters the highest number of diabetics and is thus known as the ‘Diabetes Capital of the World’. The chemical management of diabetes has side effects and hence the present study was undertaken to assess the hypoglycemic and hypolipidaemic effect of Stevia rebaudiana in patients with type 2 diabetes, non-insulin dependent diabetes mellitus (NIDDM).

Studies revealed that Stevia has been used throughout the world since ancient times for various purposes; for example, as a sweetener and a medicine. We conducted a systematic literature review to summarize and quantify the past and current evidence for Stevia

Stevia rebaudiana is a nutrient rich natural sweetest plant of Asteraceae family. The leaves naturally contain diterpene glycosides stevioside, rebaudiosides A-F, steviolbioside and dulcoside, which are responsible for its sweet taste and have commercial value all over the world as sugar substitute in foods, beverages or medicines.

Research on medicinal plants has considerably increased in recent years and is nowadays oriented towards discovering new sources beneficial to human health. Naturally low calorie sweeteners isolated from medicinal plants are gaining a great interest in their use as dietary sucrose substitutes in food and pharmaceutical products.

A randomized, controlled, cross-over and double-blinded study was conducted to assess the effectiveness and safety of Stevia rebaudiana leaves to reduce blood glucose and mean arterial pressure in Sahrawi patients with type 2 diabetes.

Diabetes mellitus is a chronic syndrome affecting many systems of the body and may be considered as a leading cause of death globally. To compare the efficacy of Stevia rebaudiana and Aspartame on hepato-renal functions, sixty adult male albino rats were divided into 6 groups; control, Stevia, Aspartame, diabetic, diabetic-treated with Stevia and diabetic-treated with Aspartame.

Now a day, various medicinal plants are becoming popular for the treatment of different diseases. Some medicinal plants are being used for the treatment of diabetes all over the world. The study was conducted to investigate the effects of powdered form of Stevia (Stevia rebaudiana Bertoni) leaves on blood glucose concentration and body weight in Streptozotocin induced diabetic rats and for its efficacy study with a patent drug, Glimepiride.

The concerned study reveals antidiabetic effects of different polyherbal combinations of six medicinal plants used in traditional medicine. Aim of the present study was to evaluate antidiabetic action of polyherbal combination of six medicinal plants.

Anti-human rotavirus (HRV) activity of hot water extracts from Stevia rebaudiana (SE) was examined. SE inhibited the replication of all four serotypes of HRV in vitro. This inhibitory effect of SE was not reduced on the prior exposure of SE to HCl for 30 min at pH 2.

Stevia rebaudiana (SR), a chrysanthemum herb, has been used as a vegetable-based sweetening additive in health drinks and in other foods. This study was conducted to investigate the antioxidant activity and the bioactive compounds found in water extracts taken from SR leaves and calli.

Steviol glycosides are currently being used as natural sweeteners by the food industry and Stevia rebaudiana has long been used as a sweet plant in South America for patients suffering from diabetes. In this study, a Stevia rebaudiana ethanolic extract (SREE) was prepared, analysed and tested for antioxidant activity in terms of free radical scavenging properties and antiproliferative effects in cervix (HeLa), pancreatic (MiaPaCa-2) and colonic (HCT116) cancer cells.

There is a continuous and urgent need to discover new antimicrobial compounds with diverse chemical structures and novel mechanisms of action due to an alarming increase in the incidence of new and reemerging infectious diseases and development of resistance to the antibiotics in current clinical use. The screening of plant extracts has been of great interest to scientists in the search for new drugs for greater effective treatment of several diseases. Therefore, plant extracts and phytochemicals with known antimicrobial properties can be of great significance in therapeutic treatments.

A procedure has been outlined for plant regeneration and antimicrobial screening of a medicinal herb, Stevia rebaudiana Bertoni, through in vitro culture of nodal segments with axillary buds.

Purpose: The aim of the present study was to investigate antimicrobial activity of the various extracts of Stevia rebaudiana leaves.

With an objective of understanding the antimicrobial potential of Stevia rebaudiana (popularly called as Stevia and synonymously known as ‘sugar substitute’ belongs to family Asteraceae), chemical extracts from its leaves were subjected to microbial assay using six solvents against ten selected pathogenic as well as food spoiling fungal (Alternaria solani, Helminthosporium solani, Aspergillus niger, Penicillium chrysogenum) and pathogenic bacterial (Escherichia coli, Bacillus subtilis, Enterococcus faecalis, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus) isolates.

Stevia rebaudiana regulates blood sugar, prevents hypertension and tooth decay. Other studies have shown that it has antibacterial as well as antiviral property.

Plants produce a diverse range of bioactive molecules, making them rich source of different types of medicines. Most of the drugs today are obtained from natural sources or semi synthetic derivatives of natural products and used in the traditional systems of medicine.

Objectives: To study adverse side effects produced by the administration of STEVIA on body weight and different body systems.

Lyme disease is a tick-borne multisystemic disease caused by Borrelia burgdorferi. Administering antibiotics is the primary treatment for this disease; however, relapse often occurs when antibiotic treatment is discontinued. The reason for relapse remains unknown, but recent studies suggested the possibilities of the presence of antibiotic resistant Borrelia persister cells and biofilms.

In the present study, we carried out a systematic research on relative antioxidant activity of aqueous leaf extract of Stevia rebaudiana. The DPPH activity of aqueous leaf extract (20, 40, 50, 100 and 200 g/ml) was increased in a dose dependent manner, which was found in the range of 40.00–72.37% as compared to ascorbic acid 64.26–82.58%.

The aim of this study was to assess the in vitro potential of ethanolic leaf extract of Stevia rebaudiana as a natural antioxidant. The DPPH activity of the extract (20, 40, 50, 100 and 200 lg/ml) was increased in a dose dependent manner, which was found in the range of 36.93–68.76% as compared to ascorbic acid 64.26–82.58%.

Leaf extract of Stevia rebaudiana promotes effects on certain physiological systems such as the cardiovascular and renal and influences hypertension and hyperglycemia. Since these activities may be correlated with the presence of antioxidant compounds, leaf and callus extracts of Stevia rebaudiana were evaluated for their total phenols, flavonoids content and total antioxidant capacity.

Anti-human rotavirus (HRV) activity of hot water extracts from Stevia rebaudiana (SE) was examined. SE inhibited the replication of all four serotypes of HRV in vitro. This inhibitory effect of SE was not reduced on the prior exposure of SE to HCl for 30 min at pH 2. Binding assay with radiolabeled purified viruses indicated that the inhibitory mechanism of SE is the blockade of virus binding.