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TANGARANA

MICROBIAL DEFENSE

TO RESOLVE:

  • BACTERIAL INFECTIONS
  • FUNGAL INFECTIONS
  • PARASITIC INFECTIONS
  • INFLAMMATION
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General Description

Tangarana – Microbial Defense is an extract produced from the bark of the Palo Santo (Triplaris peruviana) tree that is found in South America.  For generations, tribal groups in South America have used it for its anti-microbial properties.  Tangarana is a broad-spectrum anti-microbial with activity against many Lyme-related microbes, many bacteria, many rickettsia, many fungi and many protozoa.  Some of the specific microbes that are treated by Tangarana include: Anaerobic rods and cocci, Babesia, Borrelia, Chlamydia, Encephalitis, Mycosis fungoides, Rickettsia (including Coxiella and Erlichia), Aspergillus, Bartonella, Candida, Cytomegalovirus, Human Papilloma Virus (HPV) and Protozoal parasites.  If a person cannot take Banderol or Cumanda because of sensitivity/allergy, Tangarana is a reasonable substitute.

Some Reported Medicinal Properties

ANTIBACTERIAL

ANTIOXIDANT

ANTI-ARTHRITIC

ANTICHOLINESTERASE

ANTIFUNGAL

ANTHELMINTIC

ANTI-INFLAMMATORY

ANTI-LEUKORRHEAL

ANTIPROTOZOAL

ANTIRICKETTSIAL

ANTIVIRAL

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Medical Conditions [peer-reviewed journals]

BLADDER CANCER

Dietrich, F., Kaiser,S., Rockenbach, L., Figueiró, F., Bergamin, L. S., da Cunha, F. M., ... &Battastini, A. M. O. (2014). Quinovicacid glycosides purified fraction from Uncaria tomentosa induces cell death byapoptosis in the T24 human bladder cancer cell line. Food and Chemical Toxicology67, 222-229. Full Article

BRAIN CANCER

Prado, E. G., Gimenez,M. G., De la Puerta Vázquez, R., Sánchez, J. E., & Rodriguez, M. S. (2007). Antiproliferative effects ofmitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on humanglioma and neuroblastoma cell linesPhytomedicine, 14(4),280-284. Full Article

BREAST CANCER

Baraya, Y. U. S. A. B.,Wong, K. K., & Yaacob, N. S. (2017). The immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: a review. Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents), 17(6), 770-783. Full Article

García Giménez, M. D., García Prado, E., Sáenz Rodríguez, M. T., Fernández Arche, M. D. L. Á., & Puerta Vázquez-Zafra, R. D. L. (2010). Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human Ewing's sarcoma and breast cancer cell lines. Planta Medica, 76, 133-136. Full Article

Riva, L., Coradini, D., Di, G. F., De, V. F., De, N. T., De, F. S., & Pizza, C. (2001). The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line. Anticancer Research, 21(4A), 2457-2461. Full Article

CYSTITIS

Dietrich, F., Martins,J. P., Kaiser, S., Silva, R. B. M., Rockenbach, L., Edelweiss, M. I. A., ...& Battastini, A. M. O. (2015). The quinovic acid glycosides purified fraction from Uncaria tomentosa protects against hemorrhagic cystitis induced by cyclophosphamide in micePloS one, 10(7), e0131882. Full Article

DENGUE FEVER

Reis, S. R. I., Valente,L. M., Sampaio, A. L., Siani, A. C., Gandini, M., Azeredo, E. L., ... &Kubelka, C. F. (2008). Immunomodulating and antiviralactivities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2International Immunopharmacology,8(3), 468-476. Full Article

DENTURE STOMATITIS

Tay, L. Y., Dos Santos,F. A., & Jorge, J. H. (2015). Uncaria tomentosa gel against denture stomatitis: clinical reportJournal of Prosthodontics,24(7), 594-597. Full Article

ENDOMETRIOSIS

Neto, J. N., Coelho, T.M., Aguiar, G. C., Carvalho, L. R., de Araújo, A. G. P., Girão, M. J. B., & Schor, E. (2011). Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw)extractEuropean Journal of Obstetrics and Gynecology and Reproductive Biology, 154(2), 205-208. Full Article

HERPES

Caon, T., Kaiser, S.,Feltrin, C., de Carvalho, A., Sincero, T. C. M., Ortega, G. G., & Simões,C. M. O. (2014). Antimutagenic and antiherpetic activities of different preparations from Uncaria tomentosa (cat’s claw). Food and Chemical Toxicology, 66, 30-35. Full Article

Hypertension

Araujo, L. C., Feitosa, K.B., Murata, G. M., Furigo, I. C., Teixeira, S. A., Lucena, C. F., ... & Bordin, S. (2018). Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLDScientific reports, 8(1), 11013. Full Article

Zhang, Q., Zhao, J. J., Xu,J., Feng, F., & Qu, W. (2015). Medicinal uses, phytochemistry and pharmacology of the genus Uncaria. Journal of Ethnopharmacology173, 48-80. Full Article

Hao, P. P., Jiang, F., Chen,Y. G., Yang, J., Zhang, K., Zhang, M. X., ... & Zhang, Y. (2015). Traditional Chinese medication for cardiovascular diseaseNature Reviews Cardiology, 12(2), 115. Full Article

Ranilla, L. G., Kwon, Y.I., Apostolidis, E., & Shetty, K. (2010). Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin AmericaBioresource technology, 101(12), 4676-4689. Full Article

Immune-mediated diseases (diabetes)                   

Domingues, A., Sartori, A., Golim, M. A., Valente, L. M. M., da Rosa, L. C., Ishikawa, L. L. W., ...& Viero, R. M. (2011). Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?Journal of Ethnopharmacology, 137(1), 635-642. Full Article

Yessoufou,A., Gbenou, J., Grissa, O., Hichami, A., Simonin, A. M., Tabka, Z., ... &Khan, N. A. (2013). Anti-hyperglycemic effects of three medicinal plants in diabetic pregnancy: modulation of T cell proliferationBMC complementary and alternative medicine, 13(1), 77. Full Article

Araujo, L. C., Feitosa,K. B., Murata, G. M., Furigo, I. C., Teixeira, S. A., Lucena, C. F., ... &Bordin, S. (2018). Uncaria tomentosa improves insulin sensitivity and inflammation in experimental NAFLDScientific reports, 8(1),11013. Full Article

Domingues,A., Sartori, A., Golim, M. A., Valente, L. M. M., da Rosa, L. C., Ishikawa, L.L. W., ... & Viero, R. M. (2011). Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization,regulatory T cell preservation or both?Journal of ethnopharmacology,137(1), 635-642. Full Article

Mahmoudian-Sani,M., Luther, T., Asadi-Samani, M., Saeedi-Boroujeni, A., & Gholamian, N.(2017). A new approach for treatment of type 1 diabetes: Phytotherapy and phytopharmacology of regulatory T cellsJ Renal Inj Prev, 6(3),158-63. Full Article

Pane,Y. S., Ganie, R. A., Lindarto, D., & Lelo, A. (2018). The Effect of Gambier Extract on the Levels of Malondialdehyde, Superoxide Dismutase, and Blood Glucose in Type 2 Diabetes Mellitus PatientsAsian J Pharm Clin Res,11(10), 121-124. Full Article

LEUKEMIA

Pilarski, R.,Poczekaj-Kostrzewska, M., Ciesiolka, D., Szyfter, K., & Gulewicz, K.(2007). Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells. Pharmacological reports,59(5), 565. Full Article

LISTERIA

Eberlin, S., dos Santos,L. M., & Queiroz, M. L. (2005). Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bonemarrow of mice infected with Listeria monocytogenes. International Immunopharmacology, 5(7-8), 1235-1246. Full Article

Osteoarthritis

Piscoya, J., Rodriguez,Z., Bustamante, S. A., Okuhama, N. N., Miller, M. J. S., & Sandoval, M.(2001). Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis. Inflammation Research, 50(9), 442-448. Full Article

Rheumatoid Arthritis

Mur, E., Hartig, F.,Eibl, G., & Schirmer, M. (2002). Randomized double-blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritisThe Journal of Rheumatology,29(4), 678-681. Full Article

SKIN CANCER

Ciani, F., Tafuri, S.,Troiano, A., Cimmino, A., Fioretto, B. S., Guarino, A. M., ... & Calabrò,V. (2018). Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa aqueous extract in squamous carcinoma cellsJournal of Ethnopharmacology, 211, 285-294. Full Article

THYROID CANCER

Rinner, B., Li, Z. X.,Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R. (2009). Antiproliferative and pro-apoptoticeffects of Uncaria tomentosa in human medullary thyroid carcinoma cellsAnticancer Research,29(11), 4519-4528. Full Article

TUMORS

Santos, K. F.,Gutierres, J. M., Pillat, M. M., Rissi, V. B., dos Santos Araújo, M. D. C.,Bertol, G., ... & Morsch, V. M. (2016). Uncariatomentosa extract alters the catabolism of adenine nucleotides and expressionof ecto-5′-nucleotidase/CD73 and P2X7 and A1 receptors in the MDA-MB-231cell lineJournal of Ethnopharmacology, 194, 108-116. Full Article

dePaula, L. C. L., Fonseca, F., Perazzo, F., Cruz, F. M., Cubero, D., Trufelli,D. C., ... & del Giglio, A. (2015). Uncaria tomentosa (cat's claw) improves quality of life in patients with advanced solid tumorsThe Journal of Alternative and Complementary Medicine, 21(1), 22-30. Full Article

Dreifuss, A. A., Bastos-Pereira, A. L., Ávila, T. V., da Silva Soley, B., Rivero, A. J.,Aguilar, J. L., & Acco, A. (2010). Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncariatomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma modelJournal of Ethnopharmacology, 130(1), 127-133. Full Article

Medicinal Properties [peer-reviewed journals]

ADJUNCTIVE TO CHEMOTHERAPY

Allen,L., Buckner, A., Buckner, C. A., Cano, P., & Lafrenie, R. M. (2017). Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae) sensitizes THP-1 cells to radiation-induced cell deathPharmacognosy Research,9(3), 221. Full Article

Farias,I., do Carmo Araújo, M., Zimmermann, E. S., Dalmora, S. L., Benedetti, A. L.,Alvarez-Silva, M., ... & Schetinger, M. R. C. (2011). Uncaria tomentosa stimulates the proliferation of myeloid progenitor cellsJournal of Ethnopharmacology, 137(1), 856-863. Full Article

ANTIBACTERIAL

Nowakowska,J., Bany, J., Zdanowska, D., Czubaj, A., Kuraś, M., & Skopińska-Różewska, E.(2009). Experimental Immunology: The effect of the bark water extract Uncaria tomentosa on the Pseudomonas aeruginosa infection in mice. Central European Journal of Immunology, 34(3), 162-165. Full Article

ANTIFUNGAL

Moraes,R. C., Carvalho, A. R., Lana, A. J. D., Kaiser, S., Pippi, B., Fuentefria, A.M., & Ortega, G. G. (2017). In vitro synergism of a water insoluble fraction of Uncaria tomentosa combined with fluconazole and terbinafine against resistant non-Candida albicans isolates. Pharmaceutical biology, 55(1), 406-415. Full Article

Moraes,R. C., Dalla Lana, A. J., Kaiser, S., Carvalho, A. R., de Oliveira, L. F. S., Fuentefria, A. M., & Ortega, G. G. (2015). Antifungal activity of Uncaria tomentosa (Willd.) DC against resistant non-albicans Candida isolatesIndustrial Crops and Products,69, 7-14. Full Article

ANTI-INFLAMMATORY

Montserrat-dela Paz, S., Fernandez-Arche, A., de la Puerta, R., Quilez, A. M., Muriana, F.J., Garcia-Gimenez, M. D., & Bermudez, B. (2016). Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine, 23(2), 141-148. Full Article

Rojas-Duran,R., González-Aspajo, G., Ruiz-Martel, C., Bourdy, G., Doroteo-Ortega, V. H.,Alban-Castillo, J., ... & Deharo, E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143(3),801-804. Full Article

Gonçalves,C., Dinis, T., & Batista, M. T. (2005). Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry, 66(1), 89-98. Full Article

ANTIGENOTOXIC AND ANTIMUTAGENIC

Paniagua‐Pérez, R., Madrigal‐Bujaidar, E., Molina‐Jasso, D., Reyes‐Cadena, S., Álvarez‐González, I., Sánchez‐Chapul, L., & Pérez‐Gallaga, J. (2009). Antigenotoxic, antioxidant, and lymphocyte induction effects produced by pteropodine. Basic & clinical pharmacology& toxicology, 104(3), 222-227. Full Article

ANTIMICROBIAL

Herrera,D. R., Tay, L. Y., Rezende, E. C., Kozlowski Jr, V. A., & dos Santos, E. B.(2010). In vitro antimicrobial activity of phytotherapic Uncaria tomentosa against endodontic pathogensJournal of oral science,52(3), 473-476. Full Article

ANTINEOPLASTIC

Dreifuss,A. A., Bastos-Pereira, A. L., Fabossi, I. A., dos Reis Lívero, F. A., Stolf, A.M., de Souza, C. E. A., ... & Teixeira, S. (2013). Uncaria tomentosa exerts extensiveanti-neoplastic effects against the Walker-256 tumor by modulating oxidative stress and not by alkaloid activity. PLoS One, 8(2), e54618. Full Article

Rinner,B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R.(2009). Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cellsAnticancer research, 29(11), 4519-4528. Full Article

ANTIOXIDANT

Bukowska,B., Bors, M., Gulewicz, K., & Koter-Michalak, M. (2012). Uncaria tomentosa extracts protect human erythrocyte catalase against damage induced by 2, 4-D-Na and its metabolitesFood and Chemical Toxicology, 50(6), 2123-2127. Full Article

Amaral,S., Mira, L., Nogueira, J. M. F., da Silva, A. P., & Florêncio, M. H.(2009). Plant extracts with anti-inflammatory properties—A new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationshipsBioorganic & Medicinal Chemistry, 17(5), 1876-1883. Full Article

Trejo‐Tapia, G., Sepúlveda‐Jiménez, G., Trejo‐Espino, J. L., Cerda‐García‐Rojas, C. M., De La Torre, M., Rodríguez‐Monroy, M., & Ramos‐Valdivia, A. C. (2007). Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) DCcell suspension cultures via oxidative burst. Biotechnology and Bioengineering,98(1), 230-238. Full Article

Cisneros,F. J., Jayo, M., & Niedziela, L. (2005). An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation. Journal of Ethnopharmacology, 96(3), 355-364. Full Article

CENTRAL NERVOUS SYSTEM (CNS) SUPPORT

Kang,T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ...& Watanabe, H. (2002). Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyteEuropeanjournal of pharmacology, 444(1-2), 39-45. Full Article

CYTOPROTECTIVE

Sandoval,M., Charbonnet, R. M., Okuhama, N. N., Roberts, J., Krenova, Z., Trentacosti,A. M., & Miller, M. J. (2000). Cat’s Claw inhibits TNFα production and scavenges free radicals: role in cytoprotection. Free Radical Biology andMedicine,29(1), 71-78. Full Article

IMMUNOMODULATING

Lozada-Requena,I., Núñez, C., Alvárez, Y., Kahn, L., & Aguilar, J. (2015). Lymphocyte subsets, dendritic cellsand cytokine profiles in mice with melanoma treated with Uncaria tomentosa. RevistaPeruana de Medicina Experimental y Salud Publica, 32(4), 633-642.(Spanish). Full Article

Núñez,C., Lozada-Requena, I., Ysmodes, T., Zegarra, D., Saldaña, F., & Aguilar,J. (2015). Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer. Revista Peruana de Medicina Experimental y Salud Publica, 32(4), 643-651. Full Article

Montserrat-DeLa Paz, S., De la Puerta, R., Fernandez-Arche, A., Quilez, A. M., Muriana, F.J. G., Garcia-Gimenez, M. D., & Bermudez, B. (2015). Pharmacological effects of mitraphylline from Uncaria tomentosa in primary human monocytes: skew toward M2macrophages. Journal of Ethnopharmacology, 170, 128-135. Full Article

Domingues,A., Sartori, A., Valente, L. M. M., Golim, M. A., Siani, A. C., & Viero, R.M. (2011). Uncaria tomentosa Aqueous‐ethanol Extract Triggers an Immunomodulation toward a Th2 Cytokine Profile. Phytotherapy Research, 25(8), 1229-1235. Full Article

Kang,T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ...& Watanabe, H. (2002). Pteropodineand isopteropodine positively modulate the function of rat muscarinic M1 and5-HT2 receptors expressed in Xenopus oocyte. European Journal of Pharmacology,444(1-2), 39-45. Full Article

Karl-HeinzReinhard (1999). Uncaria tomentosa (Willd.) D.C.: Cat's Claw, Una de Gato, or Saventaro. The Journal of Alternative andComplementary Medicine, pp. 143-151 Full Article

Medicinal Properties
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Medical Conditions [other journals]

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Patient Reports

"Had bad fungus under my arms and on my feet and under my breasts.  I became very self-conscious about it due to the odor and constant sloughing of skin.  Tangarana got rid of it 100%. Truly happy with how it worked."-E.A.

Dosage Information

30 drops twice daily at least 30 minutes before a meal (start with 1 drop in 4 oz. of water adding a drop with each dose). For resistant microbes, doses up to 60 drops 2-3 times daily are sometimes needed. Since a Herxheimer-type, microbe die-off reaction is not uncommon when increasing the dose of Tangarana, it is usually helpful to have Nutramedix Burber and Pinella on hand to take as needed to quickly resolve the reaction.

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