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CONDURA

COMFORT

FOR TEMPORARY RELIEF OF:

  • ‍HEADACHES
  • ‍MUSCULAR AND ARTHRITIC PAIN AND OTHER TYPES OF PAIN

General Description

Condura is an extract produced from the bark of Marsdenia condurango, commonly known as condurango. CONDURA is most effective when used both sublingually and topically at the same time. Healthcare professionals using CONDURA report rapid relief of many types of pain, including muscular, arthritis, severe headaches, etc..

Some Reported Medicinal Properties

CARMINATIVE

TONIC

HEMOSTATIC

CHOLAGOGUE

DIAPHORETIC

DEPURATIVE

ANTIULCERIC

DIGESTIVE

EMETIC

Reasearch On Nutramedix Product

Medical Conditions [peer-reviewed journals]

Cancer

Bishayee, K., Mondal, J., Sikdar, S., & Khuda-Bukhsh, A. R. (2015). Condurango (Gonolobus condurango) extract activates fas receptor and depolarizes mitochondrial membrane potential to induce ROS-dependent apoptosis in cancer cells in vitro: CE-treatment on HeLa: a ROS-dependent mechanism. Journal of Pharmacopuncture, 18(3), 32. Full Article

Bailon-Moscoso, N., Romero-Benavides, J. C., Tinitana-Imaicela, F., & Ostrosky-Wegman, P. (2015). Medicinal plants of Ecuador: a review of plants with anticancer potential and their chemical composition. Medicinal Chemistry Research, 24(6), 2283-2296. Full Article

Saha, S. K., Roy, S., & Khuda-Bukhsh, A. R. (2015). Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro. Journal of Integrative Medicine, 13(6), 400-411. Full Article

Lung Cancer

Khuda-Bukhsh, A. R., & Sikdar, S. (2015). Condurango 30C induces epigenetic modification of lung cancer-specific tumour suppressor genes via demethylation. Complementary Medicine Research, 22(3), 172-179. Full Article

Sikdar, S., Mukherjee, A., & Khuda-Bukhsh, A. R. (2015). Anti-lung cancer potential of pure esteric-glycoside condurangogenin A against nonsmall-cell lung cancer cells in vitro via p21/p53 mediated cell cycle modulation and DNA damage-induced apoptosis. Pharmacognosy Magazine, 11(Suppl 1), S73. Full Article

Medicinal Properties [peer-reviewed journals]

Anti-inflammatory

De las Heras, B., Slowing, K., Benedı, J., Carretero, E., Ortega, T., Toledo, C., ... & Liso, P. A. (1998). Antiinflammatory and antioxidant activity of plants used in traditional medicine in Ecuador. Journal of Ethnopharmacology, 61(2), 161-166. Full Article

Antitumor

HAYASHI, K., WADA, K., MITSUHASHI, H., BANDO, H., TAKASE, M., TERADA, S., ... & MIZUNO, D. (1980). Antitumor active glycosides from Condurango Cortex. Chemical and Pharmaceutical Bulletin, 28(6), 1954-1958. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Patient Reports

"I recently had a terrible stomach muscle strain.  I was in so much pain, I couldn't walk for almost 36 hours and Condura was the only product that alleviated the pain and helped me heal FAST!"-Z.M.

"Debilitating cluster headaches had a hold of me for years.  I struggled with pain to the point of nausea.  Sometimes, I couldn't even see.  Can't believe nobody ever told me about Condura.  I started taking it about 4 months ago, and I haven't experienced those clusters since.  Condura works."-O.O

Dosage Information

Put 10 to 20 drops under the tongue and hold for at least two minutes before swallowing.  Also apply topically using the number of drops necessary to cover up to 3 areas of pain.  If the pain is not resolved sufficiently, place the contents of a Magnesium Malate capsule under the tongue along with a dropper full (approximately 30 drops) of Condura and hold for at least two minutes before swallowing.

Protocols

Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Condura did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.

Product Label

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CONDURA
Condura: Condurango 30C Induces Epigenetic Modification of

DNA hypermethylation induces cancer progression involving CpG island of DNA and causes inactivation of tumour suppressor genes. In this study, DNA hypermethylation status of lung cancer and ability of ultra-highly diluted Condurango 30C to modulate DNA methylation were ascertained by analysis of lung cancer-specific tumour suppressor genes in respect to placebo.

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Condura: Antitumor

The crude drug Condurango Cortex, bark of Marsdenia cundurango (Asclepiadaceae) native to north-western part of South America, has been uses as an aromatic bitter stomachic in popular medicine, and also used against cancer or syphylis in folk remedy though no report has been found on such effects.

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Condura: Lung Cancer (p21)

Marsdenia condurango (condurango) is a tropical woody vine native to South America. Our earlier study was limited to evaluation of anti-cancer potentials of crude condurango extract and its glycoside-rich components in vitro on lung cancer.

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Condura: Cancer

Methylation-specific epigenetic process and gene expression profiles of HeLa cells treated with ultra-high dilutions (HDs) of two plant extracts, Hydrastis canadensis (HC-30) and Marsdenia condurango (Condu-30), diluted 1060 times, were analyzed against placebo 30C (Pl-30) for alterations in gene profiles linked to epigenetic modifications.

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Condura: Cancer (ROS)

Condurango (Gonolobus condurango) extract is used by complementary and alternative medicine (CAM) practitioners as a traditional medicine, including homeopathy, mainly for the treatment of syphilis. Condurango bark extract is also known to reduce tumor volume, but the underlying molecular mechanisms still remain unclear.

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Condura: Cancer (Ecuador)

Ecuador is well known for its biodiversity and its ancient richness. This review provides an overview of Ecuadorian plant species in terms of the ethnobotany and chemistry of natural products in relation to anticancer activity.

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Condura: Cancer (A549)

In traditional systems of medicine including homeopathy, the Condurango extract (Con) is often used to cure stomach cancer mainly, without having any scientific validation of its anti-cancer ability. Con has therefore been tested against non-small-cell lung cancer cells (NSCLC) A549 and NCI-H522 (H522) known to contain the KRAS mutation, making them resistant to most chemotherapeutic agents.

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Condura: Anti-inflammatory

Ethanolic extracts from 15 plant species, representing eight different families, used in traditional medicine in Ecuador were evaluated for anti inflammatory and antioxidant activities. Conyza floribunda, Eupatorium articulatum, Bonafousia longituba, Bonafousia sananho, Tagetes pusilla and Piper lenticellosum extracts showed a significant anti inflammatory activity in vivo in the carrageenan-induced paw oedema model in mice.

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