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General Description

Mapalo is an herbal extract made from the bark of the Mata Palo tree (Phoradendrum crassifolium). Tribal groups in South America have reported it to have neuro-regenerative properties, pain-reducing properties, as well as many other impressive medicinal effects.  Some health care professionals have reported that Mapalo can be helpful in stopping the progression of, or reversing, disorders such as Alzheimers' disease, Parkinson's disease, and certain other neurodegenerative diseases, in part, by helping to detoxify heavy metals and other toxins from the brain.

Some Reported Medicinal Properties












Research On NutraMedix Product


An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Mapalo did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

Medical Conditions [peer-reviewed journals]

Adjunctive to Chemotherapy

Miranzadeh,S., Adib-Hajbaghery, M., Soleymanpoor, L., & Ehsani, M. (2015). Effect of adding the herb Achilleamillefolium on mouthwash on chemotherapy induced oral mucositis in cancer patients: A double-blind randomized controlled trial. European Journal of Oncology Nursing, 19(3), 207-213. Full Article


Fernández-Demeneghi, R., Rodríguez-Landa, J. F., Guzmán-Gerónimo,R. I., Acosta-Mesa, H. G., Meza-Alvarado, E., Vargas-Moreno, I., &Herrera-Meza, S. (2019). Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar ratsInternational journal of food sciences and nutrition, 1-12. Full Article


Amini Navaie, B., Kavoosian, S., Fattahi, S., Hajian-Tilaki, K., Asouri, M.,Bishekolaie, R., & Akhavan-Niaki, H. (2015). Antioxidant and cytotoxic effect of aqueous and hydroalcoholic extracts of the Achillea millefolium L. on MCF-7 breast cancer cell line. International Biological and Biomedical Journal, 1(3), 119-125. Full Article


Villalva, M., Jaime, L., Villanueva-Bermejo,D., Lara, B., Fornari, T., Reglero, G., & Santoyo, S. (2019). Supercritical anti-solvent fractionation for improving antioxidant and anti-inflammatory activities of an Achillea millefolium L. extractFoodResearch International115, 128-134. Full Article

Monforte, M. T., Smeriglio, A.,Germanò, M. P., Pergolizzi, S., Circosta, C., & Galati, E. M. (2018). Evaluation of antioxidant, antiinflammatory, and gastroprotective properties of Rubus fruticosus L. fruit juicePhytotherapy research32(7), 1404-1414. Full Article


Pereira, J. M., Peixoto, V., Teixeira,A., Sousa, D., Barros, L., Ferreira, I. C., & Vasconcelos, M. H.(2018). Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor cell lines by interfering with cell cycle and inducing apoptosis. Food and Chemical Toxicology. Full Article


Hussein, A. A., Al-Ezzy, R. M., & Abdallah, M. T. (2019). Biochemical, Enzymatic, and Immunological Study on Antimutagenic Achillea millefolium Methanolic Extract in vivo. Journal of Pharmacy and Pharmacology,7, 69-74. Full Article

Multiple Sclerosis

Ayoobi, F., Moghadam-Ahmadi, A.,Amiri, H., Vakilian, A., Heidari, M., Farahmand, H., ... & Shamsizadeh, A.(2019). Achillea millefolium is beneficial as an add-on therapy in patients with multiple sclerosis: A randomized placebo-controlled clinical trial. Phytomedicine, 52, 89-97. Full Article

Medicinal Properties [peer-reviewed journals]


Pavithra, S., & Banu, N. (2017). Free Radical Scavenging Activity and Total Antioxidant Capacity of Tin Chlorophyllin from Morinda citrifolia L. Research Journal of Pharmacy and Technology, 10(2), 453-455. Full Article

Krishnaiah, D., Bono, A., Sarbatly, R., & Anisuzzaman, S. M. (2015). Antioxidant activity and total phenolic content of an isolated Morinda citrifolia L. methanolic extract from Poly-ethersulphone (PES) membrane separator. Journal of King Saud University-Engineering Sciences, 27(1), 63-67. Full Article

de Almeida Brito, F., de Oliveira Barreto, E., Serafini, M. R., dos Santos, J. P. A., dos Santos Lima, B., Walker, C. I. B., ... & de Souza Araujo, A. A. (2015). Anti-inflammatory property and redox profile of the leaves extract from Morinda citrifolia L. Journal of Medicinal Plants Research, 9(24), 693-701. Full Article

Piaru, S. P., Mahmud, R., Abdul Majid, A. M., & Mahmoud Nassar, Z. D. (2012). Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia. Asian Pac J Trop Med, 5(4), 294-298. Full Article

Serafini, M. R., Santos, R. C., Guimaraes, A. G., dos Santos, J. P. A., da Conceicao Santos, A. D., Alves, I. A., ... & de Souza Araújo, A. A. (2011). Morinda citrifolia Linn leaf extract possesses antioxidant activities and reduces nociceptive behavior and leukocyte migration. Journal of Medicinal Food, 14(10), 1159-1166. Full Article

Masuda, M., Murata, K., Fukuhama, A., Naruto, S., Fujita, T., Uwaya, A., ... & Matsuda, H. (2009). Inhibitory effects of constituents of Morinda citrifolia seeds on elastase and tyrosinase. Journal of Natural Medicines, 63(3), 267-273. Full Article

Liu, C. H., Xue, Y. R., Ye, Y. H., Yuan, F. F., Liu, J. Y., & Shuang, J. L. (2007). Extraction and characterization of antioxidant compositions from fermented fruit juice of Morinda citrifolia (Noni). Agricultural Sciences in China, 6(12), 1494-1501. Full Article

Ramamoorthy, P. K., & Bono, A. (2007). Antioxidant activity, total phenolic and flavonoid content of Morinda citrifolia fruit extracts from various extraction processes. Journal of Engineering Science and Technology, 2(1), 70-80. Full Article

Yang, J. I. A. N., Gadi, R. A. M. A., & Thomson, T. A. L. E. N. E. (2011). Antioxidant capacity, total phenols, and ascorbic acid content of noni (Morinda citrifolia) fruits and leaves at various stages of maturity. Micronesica, 41(2), 167-176. Full Article

Yang, J., Paulino, R., Janke-Stedronsky, S., & Abawi, F. (2007). Free-radical-scavenging activity and total phenols of noni (Morinda citrifolia L.) juice and powder in processing and storage. Food Chemistry, 102(1), 302-308. Full Article

Zin, Z. M., Abdul-Hamid, A., & Osman, A. (2002). Antioxidative activities of chromatographic fractions obtained from root, fruit and leaf of Mengkudu (Morinda citrifolia L.) Food Chemistry, 78(2), 227-231. Full Article


Deng, S., & West, B. J. (2011). Antidepressant effects of noni fruit and its active principals. Asian J Med Sci, 3(2), 79-83. Full Article


Jainkittivong, A., Butsarakamruha, T., & Langlais, R. P. (2009). Antifungal activity of Morinda citrifolia fruit extract against Candida albicans. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 108(3), 394-398. Full Article


Silva, A. R. N., Ranaweera, C. B., Karunathilaka, R. N., Pathirana, R., & Ratnasooriya, W. D. (2016). Antibacterial activity of water extracts of different parts of Morinda citrifolia grown in Sri Lanka. Int J Sci Res Publ, 6, 124-7. Full Article

Schäfer, M., Sharp, P., Brooks, V. J., Xu, J., Cai, J., Keuler, N. S., ... & Darien, B. J. (2008). Enhanced bactericidal activity against Escherichia coli in calves fed Morinda citrifolia (Noni) puree. Journal of veterinary internal medicine, 22(2), 499-502. Full Article

Jayaraman, S. K., Manoharan, M. S., & Illanchezian, S. (2008). Antibacterial, antifungal and tumor cell suppression potential of Morinda citrifolia fruit extracts. International Journal of Integrative Biology, 3(1), 44-49. Full Article

De La Cruz-Sánchez, N. G., Gómez-Rivera, A., Alvarez-Fitz, P.,Ventura-Zapata, E., Pérez-García, M. D., Avilés-Flores, M., ... &González-Cortazar, M. (2019). Antibacterial activity of Morinda citrifolia Linneo seeds against Methicillin-ResistantStaphylococcus sppMicrobial pathogenesis128,347-353. Full Article


Furusawa, E., Hirazumi, A., Story, S., & Jensen, J. (2003). Antitumour potential of a polysaccharide‐rich substance from the fruit juice of Morinda citrifolia (Noni) on sarcoma 180 ascites tumour in mice. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 17(10), 1158-1164. Full Article


Muralidharan, P., & Srikanth, J. (2009). Antiulcer activity of Morinda citrifolia Linn fruit extract. J Sci Res, 1(2), 345-352. Full Article


Usha, R., Sashidharan, S., & Palaniswamy, M. (2010). Antimicrobial Activity of a Rarely Known Species, Morinda citrifolia L. Ethnobotanical Leaflets, 2010(3), 7. Full Article


Sousa, S. G., Oliveira, L. A., de Aguiar Magalhães, D., de Brito, T. V., Batista, J. A., Pereira, C. M. C., ... & da Silva, D. A. (2018). Chemical structure and anti-inflammatory effect of Polysaccharide extracted from Morinda citrifolia Linn (Noni). Carbohydrate Polymers. Full Article

Dussossoy, E., Bichon, F., Bony, E., Portet, K., Brat, P., Vaillant, F., ... & Poucheret, P. (2016). Pulmonary anti-inflammatory effects and spasmolytic properties of Costa Rican noni juice (Morinda citrifolia L.). Journal of Ethnopharmacology, 192, 264-272. Full Article

Huang, H. L., Liu, C. T., Chou, M. C., Ko, C. H., & Wang, C. K. (2015). Noni (Morinda citrifolia L.) fruit extracts improve colon microflora and exert anti-inflammatory activities in Caco-2 cells. Journal of medicinal food, 18(6), 663-676. Full Article

Nitteranon, V., Zhang, G., Darien, B. J., & Parkin, K. (2011). Isolation and synergism of in vitro anti-inflammatory and quinone reductase (QR) inducing agents from the fruits of Morinda citrifolia (noni). Food research international, 44(7), 2271-2277. Full Article

Dussossoy, E., Brat, P., Bony, E., Boudard, F., Poucheret, P., Mertz, C., ... & Michel, A. (2011). Characterization, anti-oxidative and anti-inflammatory effects of Costa Rican noni juice (Morinda citrifolia L.). Journal of ethnopharmacology, 133(1), 108-115. Full Article

Basar, S., Uhlenhut, K., Högger, P., Schöne, F., & Westendorf, J. (2010). Analgesic and antiinflammatory activity of Morinda citrifolia L.(Noni) fruit. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 24(1), 38-42. Full Article

Akihisa, T., Matsumoto, K., Tokuda, H., Yasukawa, K., Seino, K. I., Nakamoto, K., ... & Kimura, Y. (2007). Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni). Journal of Natural Products, 70(5), 754-757. Full Article

Mckoy, M. G., Thomas, E. A., & Simon, O. R. (2002). Preliminary investigation of the anti-inflammatory properties of an aqueous extract from Morinda citrifolia (Noni). In Proceedings of the Western Pharmacology Society (Vol. 45, pp. 76-78). Seattle, Wash.: The Society. Full Article


Anekpankul, T., Goto, M., Sasaki, M., Pavasant, P., & Shotipruk, A. (2007). Extraction of anti-cancer damnacanthal from roots of Morinda citrifolia by subcritical water. Separation and Purification Technology, 55(3), 343-349. Full Article


Wang, M. Y., Anderson, G., Nowicki, D., & Jensen, J. (2008). Hepatic protection by noni fruit juice against CCl 4-induced chronic liver damage in female SD rats. Plant foods for human nutrition, 63(3), 141-145. Full Article

Stadlbauer, V., Fickert, P., Lackner, C., Schmerlaib, J., Krisper, P., Trauner, M., & Stauber, R. E. (2005). Hepatotoxicity of NONI juice: report of two cases. World journal of gastroenterology: WJG, 11(30), 4758. Full Article


Palu, A. K., Kim, A. H., West, B. J., Deng, S., Jensen, J., & White, L. (2008). The effects of Morinda citrifolia L.(noni) on the immune system: its molecular mechanisms of action. Journal of Ethnopharmacology, 115(3), 502-506. Full Article

Nayak, S., & Mengi, S. (2010). Immunostimulant activity of noni (Morinda citrifolia) on T and B lymphocytes. Pharmaceutical biology, 48(7), 724-731. Full Article


Pachauri, S. D., Tota, S., Khandelwal, K., Verma, P. R. P., Nath, C., Hanif, K., ... & Dwivedi, A. K. (2012). Protective effect of fruits of Morinda citrifolia L. on scopolamine induced memory impairment in mice: a behavioral, biochemical and cerebral blood flow study. Journal of ethnopharmacology, 139(1), 34-41. Full Article


Harada, S., Hamabe, W., Kamiya, K., Satake, T., Yamamoto, J., & Tokuyama, S. (2009). Preventive effect of Morinda citrifolia fruit juice on neuronal damage induced by focal ischemia. Biological and Pharmaceutical Bulletin, 32(3), 405-409. Full Article


Nayak, B. S., Sandiford, S., & Maxwell, A. (2009). Evaluation of the wound-healing activity of ethanolic extract of Morinda citrifolia L. leaf. Evidence-Based Complementary and Alternative Medicine, 6(3), 351-356. Full Article


Assi, R. A., Darwis, Y., Abdulbaqi, I. M., Vuanghao, L., & Laghari, M. H. (2017). Morinda citrifolia (Noni): A comprehensive review on its industrial uses, pharmacological activities, and clinical trials. Arabian Journal of Chemistry, 10(5), 691-707. Full Article

Singh, D. R. (2012). Morinda citrifolia L.(Noni): A review of the scientific validation for its nutritional and therapeutic properties. Journal of Diabetes and Endocrinology, 3(6), 77-91. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]


Conference Presentations

Patient Reports

"I was diagnosed with varicose veins and they caused discomfort all day at work.  The medicine that my doctor prescribed didn't work, so I figured I'd try this [Mapalo].  Within a day, I had no more pain and they healed up."-A.N.

"This product has helped my son tremendously. It has been instrumental in reducing his motor tics.  We started with 6 drops in water once a day and worked up to maximum dose after two months."-C.L.

“Awesome! Just an awesome product, immediately noticed a positive change in my son's mood.” – K.T

"When my vertigo comes, I take Mapalo. It's really good for my brain." -M.D

Dosage Information

Note: This product should be used with 10 drops of Burbur or Parsley (in the same water) for more complete elimination of toxins .
Put 15 drops in 4 oz. of water and wait one minute before drinking. Take twice daily at least 30 minutes before meals (start with 1 drop in 4 oz. of water adding a drop with each dose).
Moderate to Severe Toxicity and Herxheimer-like Reaction: Put 1-15 drops in 2-4 oz. of water and wait one minute before drinking. Take every 15 minutes until feeling better.  Can also put 2 droppers full (approximately 60 drops) in at least 16 oz. of water and sip over a 2 hour period, repeating until feeling better.


Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Mapalo did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

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Mapalo: HSV

Ethanolic and aqueous extracts of seven plant species used in the traditional medicine of Bolivia have been tested for their antiviral activity against herpes simplex type I (HSV-1), vesicular stomatitis virus (VSV), and poliovirus type 1.

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