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General Description

Serrapeptase – Dietary Supplement is a strong proteolytic enzyme.  The late Hans Nieper, MD, was a German physician that was well known for his use and study of proteolytic enzymes in the treatment of artherosclerosis. He called Serrapeptase the miracle enzyme after using ultrasound to measure its ability to effectively dissolve arterial plaque without harming healthy cells lining the arterial wall. One of the most significant features of Serrapeptase (Helianthus tuberosus) is that it does not harm any living cells or tissues in the human body; it only dissolves non-living tissue such as cysts, hard and soft arterial plaque, blood clots, etc. The primary purpose of Serrapeptase in a protocol for Lyme disease is to dissolve fibrin layers surrounding harmful microbes associated with Lyme disease such as Borrelia, Babesia, Bartonella and Ehrlichia. The fibrin layer covering these microbes causes them to be hidden from the immune system; once the fibrin is dissolved the immune system can more easily identify and eliminate the harmful microbes.

Some Reported Medicinal Properties












Research On NutraMedix Product

In vitro – Lyme disease 

Priyanka A.S. Theophilus M.S., Eva Sapi Ph.D. (2013). In Vitro Effect of Peruvian Antimicrobial Agents on Borrelia burgdorferi Full Article

Medical Conditions [peer-reviewed journals]


Zhao, B., Li, L. F., Lv, F., Li, Z. Z., Zhang, L., Zhai,Y., & Zhang, G. (2017). Pharmacodynamic study of Jerusalem artichoke particles in type I and II diabetic rat models. International Journal of Herbs, Spices and Medicinal Plants, 2(1), 018-024. Full Article

Chang, W. C., Jia, H., Aw, W., Saito, K., Hasegawa,S., & Kato, H. (2014). Beneficial effects of soluble dietary Jerusalem artichoke (Helianthus tuberosus) in the prevention of the onset of type 2 diabetes and non-alcoholic fatty liver disease in high-fructose diet-fed rats. British Journal of Nutrition,112(5), 709-717. Full Article

Medicinal Properties [peer-reviewed journals]

Allelopathic Effects

Tesio, F.,Weston, L. A., Vidotto, F., & Ferrero, A. (2010). Potential allelopathic effects of Jerusalem artichoke (Helianthus tuberosus) leaf tissues. Weed Technology, 24(3), 378-385. Full Article


Kang, Y. M., Lee, K. Y., & An, H. J. (2018). Inhibitory Effects of Helianthus tuberosus Ethanol Extract on Dermatophagoides farina body-induced Atopic Dermatitis Mouse Model and Human Keratinocytes. Nutrients, 10(11), 1657. Full Article

Dias, N. S.,Ferreira, J. F., Liu, X., & Suarez, D. L. (2016). Jerusalem artichoke (Helianthus tuberosus, L.) maintains high inulin, tuber yield, and antioxidant capacity under moderately-saline irrigation waters. Industrial crops and products, 94, 1009-1024. Full Article

Yuan, X., Gao, M., Xiao, H., Tan, C., & Du, Y. (2012).Free radical scavenging activities and bioactive substances of Jerusalem artichoke (Helianthus tuberosus L.) leaves. Food Chemistry, 133(1), 10-14. Full Article

Xue, Y. F.,& Liu, Z. P. (2008). Antioxidant enzymes and physiological characteristics in two Jerusalem artichoke cultivars under salt stress. Russian Journal of Plant Physiology, 55(6), 776-781. Full Article


Chen, F., Long,X., Yu, M., Liu, Z., Liu, L., & Shao, H. (2013). Phenolics and antifungal activities analysis in industrial crop Jerusalem artichoke (Helianthus tuberosus L.) leaves. Industrial crops and products, 47, 339-345. Full Article


Ma, X. Y.,Zhang, L. H., Shao, H. B., Xu, G., Zhang, F., Ni, F. T., & Brestic, M.(2011). Jerusalem artichoke (Helianthus tuberosus), a medicinal salt-resistant plant has high adaptability and multiple-use values. Journal of Medicinal Plants Research, 5(8), 1272-1279. Full Article

Prebiotic effect

Samal, L., Chaturvedi, V. B., Saikumar, G., Somvanshi, R., & Pattanaik, A. K. (2015). Prebiotic potential of Jerusalem artichoke (Helianthus tuberosus L.) in Wistar rats: effects of levels of supplementation on hindgut fermentation, intestinal morphology, blood metabolites and immune response. Journal of the Science of Food and Agriculture, 95(8), 1689-1696. Full Article

Tiengtam, N., Khempaka, S., Paengkoum, P., & Boonanuntanasarn, S. (2015). Effects of inulin and Jerusalem artichoke(Helianthus tuberosus) as prebiotic ingredients in the diet of juvenile Nile tilapia (Oreochromis niloticus). Animal Feed Science and Technology, 207,120-129. Full Article

Rubel, I. A.,Pérez, E. E., Genovese, D. B., & Manrique, G. D. (2014). In vitro prebiotic activity of inulin-rich carbohydrates extracted from Jerusalem artichoke (Helianthus tuberosus L.) tubers at different storage times by Lactobacillus paracasei. Food Research International, 62, 59-65. Full Article

Ramnani, P.,Gaudier, E., Bingham, M., van Bruggen, P., Tuohy, K. M., & Gibson, G. R.(2010). Prebiotic effect of fruit and vegetable shots containing Jerusalem artichoke inulin: a human intervention study. British journal of nutrition, 104(2), 233-240. Full Article

Various Properties

Van Doan, H.,Doolgindachbaporn, S., & Suksri, A. (2016). Effect of Lactobacillus plantarum and Jerusalem artichoke (Helianthus tuberosus) on growth performance, immunity and disease resistance of Pangasius catfish (Pangasius bocourti, Sauvage 1880). Aquaculture nutrition, 22(2),444-456. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Lyme disease

Why this Finnish Doctor Believes in Herbs, Marjo Valonen MD, Townsend Letter, July2018 FullArticle

A Hidden Epidemic: Integrative Treatment of Lyme Disease, Scott Forsgren, March 2009 Full Article


Conference Presentations

Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video

Patient Reports

"I'm confident these supplements healed my inflammation - my bloodwork proved it. A fantastic supplement for all kinds of inflammation."-S.S.

“Love this stuff!! For mold, Yeast and lyme biofilm breakdown..this stuff works!!!!!” – C.B

“My husband feels the difference in his knees when he takes this. Pain before, gone after. He takes one twice a day” – N.M

"My physician prescribed this product for my high blood fibrinogen, which placed me at high risk for a heart attack. This brought it into normal range quickly. It really worked." -C.S.

“Everyone needs to take this. This biofilm buster is a must for those suffering from antibiotic-resistant organisms, tumors, biofilms, fibrosis, and cholesterol plaques. Has caused a major improvement id my DD who was septic with Lyme followed by various antibiotic therapies. This is key to her turn around. We finally see an improvement in her condition.” – L.F

“This is a very powerful enzyme that has made a world of difference for me. It's a good idea to ask your doctor before you use it because it is so powerful.” – E.S

“It may help clots/scar tissue/Lyme cysts and may lower Ca that may be clogging blood vessels. It is great to help me. I take it at night or when no food is in the body. I am glad this exists to help. It is an enzyme the silkworm uses to eat itself out of the cocoon. Awesome help for me!” – S.M

Dosage Information

1-3 capsules with 8 oz. of water 1-3 times daily at least 30 min. before meals and several hours after food.


Safety Information

Product Label

Serrapeptase: Diabetes (type 2)

Jerusalem artichoke (JA) has the potential to attenuate lipid disturbances and insulin resistance (IR), but the underlying mechanisms are not well understood. In the present study, we elucidated the physiological responses and mechanisms of JA intervention with a comprehensive transcriptome analysis.

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Serrapeptase: Diabetes (particles)

To study the therapeutic effect of Jerusalem artichoke particles in type I and type II diabetic rats. Male Sprague–Dawley (SD) rats were intraperitoneally injected with 30 mg/kg streptozotocin (STZ) for 3 consecutive days to generate a type I diabetic rat model. The rats were orally administered Jerusalem artichoke particles (50, 100, or 150 mg/kg) once a day for 3 consecutive weeks.

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Serrapeptase: Antioxidant (atopic)

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by complex symptoms. To treat AD without adverse effects, alternative therapeutic agents are required.The tubers of Helianthus tuberosus L. (Jerusalem artichoke) have been used in folk remedies for diabetes and rheumatism. However, its effect on AD development remains unknown. Therefore, this study examined the inhibitory effect of H. tuberosus (HT) on AD skin symptoms using an NC/Nga mouse model and HaCaT keratinocytes.

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Serrapeptase: Prebiotic Effect (fruit)

The biological and clinical importance of the human gastrointestinal microbiota is becoming increasingly recognised by consumers and healthcare workers. Although many disease states involve bacterial metabolism, the human gut microbiota may be considered extremely relevant for the maintenance and improvement in host health.

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Serrapeptase: Various properties

This study evaluated the effects of Jerusalem artichoke (JA) and Lactobacillus plantarum singly or combined on growth, immunity and disease resistance of Pangasius bocourti.

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Serrapeptase: Prebiotic Effect (wistar)

Many studies have been conducted using purified prebiotics such as inulin or fructooligosaccharides (FOS) as nutraceuticals, but there is very little information available on the prebiotic potential of raw products rich in inulin and FOS, such as Jerusalem artichoke (JA; Helianthus tuberosus L.). The present experiment aimed to evaluate the prebiotic effects of JA tubers in rats.

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Serrapeptase: Prebiotic Effect (Tilapia)

This study evaluated the prebiotic effects of dietary inulin and Jerusalem artichoke tuber (JA) on juvenile Nile tilapia (Oreochromis niloticus).

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Serrapeptase: Prebiotic Effect (inulin-rich)

In the present work the in vitro prebiotic activity of inulin-rich carbohydrates using Lactobacillus paracasei as probiotic microorganism was determined. With this purpose, inulin-rich carbohydrates samples from Jerusalem artichoke tubers stored at 4–5 °C during different times along an overall period of 8 months were extracted.

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Serrapeptase: Antioxidant

Oxygen-centred free radicals and other reactive oxygen species (ROS) can be generated as by-products during oxidative progresses of living organisms. Many human diseases, including accelerated ageing, cancer, cardiovascular disease, neurodegenerative disease and inflammation, are linked to excessive amounts of free radicals. The antioxidants are necessary to cure these diseases.

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Serrapeptase: Antioxidant (Salt)

The effects of NaCl stress on the activity of antioxidant enzymes, lipid peroxidation, cell membrane stability, net photosynthetic rate, gas-exchange, and chlorophyll content were investigated in two Jerusalem artichoke cultivars, Dafeng (salt-tolerant) and Wuxi (salt-sensitive), grown under control (nutrient solution) or salt stress (nutrient solution con- taining 75, 150, and 225 mM NaCl) conditions for 7 days.

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Serrapeptase: Antioxidant (irrigation)

Information on management strategies and alternative crops adaptable to saline waters is scarce. We investigated the effects of high-salinity water (HSW) blended or sequentially applied with low-salinity water (LSW) on growth, mineral nutrients, and tuber biochemistry of Jerusalem artichoke (Helianthus tuberosus, L. cv. ‘Stampede’).

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Serrapeptase: Antimicrobial

The Jerusalem artichoke (Helianthus tuberosus), which is also called the sunchoke, sunroot, topinambur or earth apple, is an Angiosperm plant species of Compositae family.

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Serrapeptase: Antifungal

Spoilage of industrial fruits and vegetables in storage and transportation due to fungal infection results in significant losses, and new natural antifungal treatments would have a large economic value. The extracts of antifungal compounds and phenolic acids from Jerusalem artichoke (Helianthus tuberosus L.) leaves were investigated for potential use in enhancing preservation of fruits and vegetables in storage.

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Serrapeptase: Allelopathic Effects

Jerusalem artichoke has been reported to colonize several ecological niches and agronomic crops in southern Europe. This plant is also of interest because of its high biomass production and its potential to produce ethanol for biofuel. Allelopathy may be an advantageous trait in Jerusalem artichoke under cultivation, as it potentially reduces weed interference with the crop, theoretically allowing a reduction of mechanical or chemical input required for weed management.

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