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PINELLA

BRAIN-NERVE CLEANSE

FOR RESOLVING BRAIN AND SPINAL CORD TOXICITY

General Description

Pinella – Brain & Nerve Cleanse is an herbal extract made from Pimpinella anisum. It has been used by indigenous groups for hundreds of years. Pinella is an integral component of a Lyme disease protocol developed by William Lee Cowden, MD.  Dr. Cowden and other health care professionals report that it is very effective in eliminating both man-made toxins and biotoxins from the brain, the spinal cord and peripheral nerves. Both patients and health care professionals also report that many times there is a significant reduction in brain fog, even after only one dose.

Some Reported Medicinal Properties

ANALGESIC

ANODYNE

ANTI-BACTERIAL

ANTI-CONVULSANT

ANTI-FUNGAL

ANTI-MICROBIAL

ANTIOXIDANT

ANTIVIRAL

APHRODISIAC

AROMATIC

CARMINATIVE

DIAPHORIC

DISINFECTANT

DIURETIC

DYSMENORRHEA

GALACTAGOGUE

HYPOGLYCEMIC

HYPOLIPIDEMIC

MENOPAUSAL HOT FLASHES

MUSCLE RELAXANT

NERVINE

STIMULANT

SUDORIFIC

Reasearch On Nutramedix Product

in vivo – Anti-inflammatory

Establishment of the Potential Anti-inflammatory Effect of the product known as Pinella. The study demonstrated that Pinella had a marked anti-inflammatory effect and was 64% as effective as Feldene, a non-steroidal anti-inflammatory drug also known as PIROXICAM. University of Guayaquil, Department of Chemical Sciences, Guayaquil, Ecuador (2005). Full Article

IN VIVO – ACCUTE ORAL TOXICITY TESTS

An acute Oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Pinella did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.  Full Article

Medical Conditions [peer-reviewed journals]

Cancer

AlSalhi, M. S., Devanesan, S., Alfuraydi, A. A., Vishnubalaji, R., Munusamy, M. A., Murugan, K., ... & Benelli, G. (2016). Green synthesis of silver nanoparticles using Pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells. International Journal of Nanomedicine, 11, 4439. Full Article

Kadan, S., Rayan, M., & Rayan, A. (2013). Anticancer activity of anise (Pimpinella anisum L.) seed extract. The Open Nutraceuticals Journal, 6(1). Full Article

Diabetes

Shobha, R. I., Rajeshwari, C. U., & Andallu, B. (2013). Anti-peroxidative and anti-diabetic activities of aniseeds (Pimpinella anisum L.) and identification of bioactive compounds. American Journal of Phytomedicine and Clinical Therapeutics, 1(5), 516-527. Full Article

Medicinal Properties [peer-reviewed journals]

Antibacterial

Foroughi, A., Pournaghi, P., Tahvilian, R., Zangeneh, M. M., Zangeneh, A., & Moradi, R. (2016). Assessment of chemical composition and antibacterial effects of Anethole-rich hydroalcoholic extract of Pimpinella anisum. International Journal of Pharmaceutical and Clinical Research, 8(11), 1459-1463. Full Article

Al Maofari, A., El Hajjaji, S., Debbab, A., Zaydoun, S., Ouaki, B., Charof, R., ... & Mosaddak, M. (2013). Chemical composition and antibacterial properties of essential oils of Pimpinella Anisum L. growing in Morocco and Yemen. Scientific Study & Research. Chemistry & Chemical Engineering, Biotechnology, Food Industry, 14(1), 11. Full Article

Al-Bayati, F. A. (2008). Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts. Journal of Ethnopharmacology, 116(3), 403-406. Full Article

Akhtar, A., Deshmukh, A. A., Bhonsle, A. V., Kshirsagar, P. M., & Kolekar, M. A. (2008). In vitro antibacterial activity of Pimpinella anisum fruit extracts against some pathogenic bacteria. Veterinary World, 1(9), 272-274. Full Article

Antioxidant

Tavallali, V., Rahmati, S., & Bahmanzadegan, A. (2017). Antioxidant activity, polyphenolic contents and essential oil composition of Pimpinella anisum L. as affected by zinc fertilizer. Journal of the Science of Food and Agriculture, 97(14), 4883-4889. Full Article

Jamshidzadeh, A., Heidari, R., Razmjou, M., Karimi, F., Moein, M. R., Farshad, O., ... & Shayesteh, M. R. H. (2015). An in vivo and in vitro investigation on hepatoprotective effects of Pimpinella anisum seed essential oil and extracts against carbon tetrachloride-induced toxicity. Iranian Journal of Basic Medical Sciences, 18(2), 205. Full Article

Singh, G., Kapoor, I. P. S., Singh, P., de Heluani, C. S., & Catalan, C. A. N. (2008). Chemical composition and antioxidant potential of essential oil and oleoresins from anise seeds (Pimpinella anisum L.). International Journal of Essential Oil Therapeutics, 2(3), 122-130. Full Article

Gülçın, İ., Oktay, M., Kıreçcı, E., & Küfrevıoǧlu, Ö. İ. (2003). Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chemistry, 83(3), 371-382. Full Article

Anticonvulsant

Karimzadeh, F., Hosseini, M., Mangeng, D., Alavi, H., Hassanzadeh, G. R., Bayat, M., ... & Gorji, A. (2012). Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. BMC Complementary and Alternative Medicine, 12(1), 76. Full Article

Pourgholami, M. H., Majzoob, S., Javadi, M., Kamalinejad, M., Fanaee, G. H. R., & Sayyah, M. (1999). The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. Journal of Ethnopharmacology, 66(2), 211-215. Full Article

Antifungal

Yazdani, D., Rezazadeh, S. H., Amin, G. H., Abidin, Z., Shahnazi, S., & Jamalifar, H. (2009). Antifungal activity of dried extracts of anise (Pimpinella anisum L.) and star anise (Illicium verum Hook. f.) against dermatophyte and saprophyte fungi. Journal of Medicinal Plants, 1(29), 24-29. Full Article

Sharifi, R., Kiani, H., Farzaneh, M., & Ahmadzadeh, M. (2008). Chemical composition of essential oils of Iranian Pimpinella anisum L. and Foeniculum vulgare miller and their antifungal activity against postharvest pathogens. Journal of Essential Oil Bearing Plants, 11(5), 514-522. Full Article

Kosalec, I., Pepeljnjak, S., & Kuštrak, D. (2005). Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharmaceutica, 55(4), 377-385. Full Article

Shukla, H. S., & Tripathi, S. G. (1987). Antifungal substance in the essential oil of anise (Pimpinella anisum L.). Agricultural and Biological Chemistry, 51(7), 1991-1993. Full Article

Antimicrobial

Mohamed, H. S. A. A., Abdelgadir, W. S., & Almagboul, A. Z. (2015). In vitro antimicrobial activity of Anise seed (Pimpinella anisum L.). International Journal of Advanced Research, 3(1), 359-367. Full Article

Mohammed, M. J. (2009). Isolation and identification of Anethole from Pimpinella anisum L. fruit oil. An antimicrobial study. J Pharma Res 2009; 915, 919. Full Article

Gende, L. B., Maggi, M. D., Fritz, R., Eguaras, M. J., Bailac, P. N., & Ponzi, M. I. (2009). Antimicrobial activity of Pimpinella anisum and Foeniculum vulgare essential oils against Paenibacillus larvae. Journal of Essential Oil Research, 21(1), 91-93. Full Article

Antiviral

Lee, J. B., Yamagishi, C., Hayashi, K., & Hayashi, T. (2011). Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum. Bioscience, Biotechnology, and Biochemistry, 75(3), 459-465. Full Article

Shukla, H. S., Dubey, P., & Chaturvedi, R. V. (1989). Antiviral properties of essential oils of Foeniculum vulgare and Pimpinella anisum L. Agronomie, 9(3), 277-279. Full Article

Hepatoprotective

Cengiz, N., Ozbek, H., & Him, A. (2008). Hepatoprotective effects of Pimpinella anisum seed extract in rats. Pharmacologyonline, 3, 870-874. Full Article

Relaxant

Tirapelli, C. R., de Andrade, C. R., Cassano, A. O., De Souza, F. A., Ambrosio, S. R., da Costa, F. B., & de Oliveira, A. M. (2007). Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. Journal of Ethnopharmacology, 110(1), 23-29. Full Article

Boskabady, M. H., & Ramazani-Assari, M. (2001). Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism (s). Journal of Ethnopharmacology, 74(1), 83-88. Full Article

Various Properties

Shojaii, A., & Abdollahi Fard, M. (2012). Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharmaceutics, 2012. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Patient Reports

"This is the best herb I have taken for clearing "brain fog." I could feel immediate effects as soon as I began taking it!" -K.F.

"This has worked wonders for me. I am now able to bring up words faster and it has improved my sleep." -J.M.

Dosage Information

General Detox Aid: Take 10 drops in 4 oz. of water 1-2 times daily. 

Mild Toxicity, Brain Fog: Take 10 drops 3-4 times daily.  May be taken several times per day as needed.  

Moderate to Severe Toxicity, Herxheimer Reaction (healing crisis): take 10 drops every 10-15 minutes in 2 oz. of water until symptoms are resolved.  Can also put 2 droppers full (approximately 60 drops) in at least 16 oz. of water and sip over a 2-hour period, repeating until symptoms are resolved.  

Note: This product should be used with 10 drops of Burbur or Parsley for more complete elimination of toxins (in the same water).

Protocols

Safety Information

An acute Oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Pinella did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.  Full Article

Product Label

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PINELLA
Pinella: Toxicity Study (English Translated)

To study adverse side effects produced by the administration of PINELLA on body weight and different body systems.

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Pinella: Relaxant (smooth)

Because Pimpinella anisum is highly used in the folk medicine, a study of its physiological properties was deemed necessary and informative. At present, the mechanisms involved in the relaxant action induced by the extract of Pimpinella anisum are poorly understood. This work aimed to investigate the possible mechanism(s) underlying the relaxant action of the hidroalcoholic extract of Pimpinella anisum on rat anococcygeus smooth muscle.

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Pinella: Antimicrobial

The essential oil obtained by hydrodistillation from the fruits of Pimpinella anisum L. (green anise) and Foeniculum vulgare Miller (fennel) were analyzed by GC and GC/MS and physicochemical properties.

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Pinella: Relaxant (guinea)

In the present study the relaxant effects of essential oil, aqueous and ethanol extracts of this plant in comparison with both saline and theophylline were studied by a more standard method. In addition the anticholinergic effect of essential oil of P. anisum in comparison with atropine was also studied.

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Pinella: Antimicrobial (isolation)

The present study was conducted to isolate the most important bioactive compound from Pimpinella anisum L. fruit oil.

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Pinella: Antimicrobial (Anise)

Medicinal plants synthesize a vast array of secondary metabolites that are important for human life.

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Pinella: Hepatoprotective

Pimpinella anisum is a member of the Umbelliferae and is found in the North-Eastern Anatolia. In Turkish folk medicine, Pimpinella species have been used as analgesic, antiinflammatory, appetizing, hypnotic, expectorant, antibacterial and hepatoprotective agents and to increase milk secretion. The seeds of P. anisum contain 1.5-6% essential oil, 10-20% fixed oil and 18% protein.

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Pinella: Anti-Inflammatory Study (English Translated)

The auricular edema is achieved by applying 12-0- Tetradecanoil Forbol-13 Acetate (TPA), one of the components responsible for the irritating action of croton oil, into the auditory pavilion of the mouse.

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Pinella: Antifungal (miller)

Increasing attentions have been paid on the application of essential oils and plant extracts for control of postharvest pathogens due to their natural origin and less appearance of resistance in fungi pathogens.

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Pinella: Diabetes (bioactive)

In this study, lipid peroxidation (marker of oxidative stress) inhibitory effect and antidiabetic activity of various fractions of aniseed (Pimpinella anisum L.) obtained by sequential fractionation of methanolic extract using hexane, benzene, ethyl acetate, n-butanol and water were evaluated using in vitro methods and model systems.

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Pinella: Cancer (Colon)

We studied a green synthesis route to produce AgNPs by using an aqueous extract of Pimpinella anisum seeds (3 mM). Their antimicrobial activity and cytotoxicity on human neonatal skin stromal cells (hSSCs) and colon cancer cells (HT115) were assessed.

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Pinella: Broad Spectrum

Pimpinella anisum (anise), belonging to Umbelliferae family, is an aromatic plant which has been used In Iranian traditional medicine (especially its fruits) as carminative, aromatic, disinfectant, and galactagogue. Because the wide traditional usage of Pimpinella anisum for treatment of diseases, in this review published scientific reports about the composition and pharmacological properties of this plant were collected with electronic literature search of GoogleScholar, PubMed, Sciencedirect, Scopus, and SID from 1970 to 2011.

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Pinella: Antiviral (oils)

The antiviral activity of the essential oils of Foeniculum vulgare Mill. and Pimpinella anisum L. has been tested against PVX (potato virus X), TMV (tobacco mosaic virus) and TRSV (tobacco ring spot virus) on the hypersensitive host Chenopodium amaranticolor.

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Pinella: Antiviral (immunostimulating)

Three antiviral and immunostimulating substances (LC1, LC2 and LC3) were isolated from a hot water extract of seeds of Pimpinella anisum by combination of anion-exchange, gel filtration and hydrophobic interaction column chromatographies. Chemical and spectroscopic analyses revealed them to be lignin-carbohydrate-protein complexes.

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Pinella: Antioxidant (zinc)

The antioxidant activity and essential oil content of plants may vary considerably with respect to environmental conditions, especially nutrient availability. Among micronutrients, zinc (Zn) is needed by plants in only small amounts but is crucial to plant development. This study aimed to evaluate the effects of Zn fertilization on the antioxidant activity, polyphenolic contents and essential oil composition of Pimpinella anisum fruit.

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Pinella: antioxidant (screening)

In this study, antioxidant and antimicrobial activities of water and ethanol extracts of anise (Pimpinella anisum L.) seed (PAS) were investigated. The antioxidant properties of both extracts of PAS were evaluated using different antioxidant tests, including reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities.

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Pinella: Antioxidant (comp)

Recently, interest in plant-derived food additives has grown, mainly because of toxic effects associated with synthetic antioxidants. In the present study, the chemical composition and antioxidant properties of essential oil and oleoresins of the seeds of anise (Pimpinella anisum) was investigated.

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Pinella: Antioxidant (carbon)

Protective effects of different extracts and essential oil from Pimpinella anisum L. seeds were examined against carbon tetrachloride (CCl4)-induced toxicity. The parameters such as serum transaminases, lactate dehydrogenase activity, hepatic glutathione content, liver lipid peroxidation and histopathological changes of liver were assessed as toxicity markers. In the in vitro model of this study, markers such as cell viability, cellular reduced and oxidized glutathione and lipid peroxidation in HepG2 cells were evaluated.

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Pinella: Antifungal (fluid)

Antifungal activities of fluid extract and essential oil obtained from anise fruits Pimpinella anisum L. (Apiaceae) were tested in vitro on clinical isolates of seven species of yeasts and four species of dermatophytes.

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Pinella: Antifungal (Dried)

Medicinal plants synthesize a vast array of secondary metabolites that are important for human life. For medicinal purpose, antimicrobial activity of substances derived from plant extracts has been recognized for many years. Pimpinella anisum L. (Apiaceae) and Illicium verum Hook. f. (Illiciaceae) plant species, have been used for treatment of infectious diseases in Iranian traditional medicine.

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Pinella: Antifungal (Anise)

Previously, we reported the antifungal properties of some essential oils of angiosperms.

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Pinella: anticonvulsant

This study investigates anticonvulsant effects of an essential oil of the fruits of Pimpinella anisum (Umbelliferae), a folkloric remedy in the Iranian traditional medicine, against seizures induced by pentylenetetrazole (PTZ) or maximal electroshock (MES) in male mice.

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Pinella: anticonvulsant (brain)

Essential oil of Pimpinella anisum L. Apiaceae (anise oil) has been widely used in traditional Persian medicine to treat a variety of diseases, including some neurological disorders. This study was aimed to test the possible anti-seizure and anti-hypoxia effects of anise oil.

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Pinella: Antibacterial

The antibacterial activities of the aqueous, 50% (v/v) methanol,acetone and petroleum ether extracts of Pimpinella anisum (L) fruits were studied.

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Pinella: Antibacterial (yemen)

We report in this study the chemical composition and antibacterial activities of the seed’s essential oils of Pimpinella anisum L. collected from Morocco and Yemen.

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Pinella: Antibacterial (Synergistic)

Essential oils (EOs) and methanol extracts obtained from aerial parts of Thymus vulgaris and Pimpinella anisum seeds were evaluated for their single and combined antibacterial activities against nine Gram-positive and Gram-negative pathogenic bacteria: Staphylococcus aureus, Bacillus cereus, Escherichia coli, Proteus vulgaris, Proteus mirabilis, Salmonella typhi, Salmonella typhimurium, Klebsiella pneumoniae and Pseudomonas aeruginosa.

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Pinella: Antibacterial (composition)

Increasing microbial resistance to chemical antibiotics and their probabilistic side effects cause popularity of medicinal plants, so there is an instantaneous and steady need for novel antimicrobial compounds from plants.

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