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MACA

HORMONAL BALANCE

FOR IMPROVING TESTOSTERONE, PMS & MENOPAUSAL SYMPTOMS, AND SEXUAL DYSFUNCTION

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General Description

Maca – Hormonal Balance is an herbal extract made from the root of the Maca plant. The cultivation of Maca can be traced back thousands of years, being an integral part of the diet and commerce of the high Andes region of Peru. Maca was domesticated by the Incas and primitive cultivars of Maca have been found in archaeological sites dating as far back as 1600 B.C. Maca helps to improve the hormonal balance in both men and women as they age. Maca is also helpful in building up the strength of the adrenal gland. Maca is a good rejuvenating herb.

Some Reported Medicinal Properties

ANXIETY

ESTROGEN IMBALANCE

SEXUAL DYSFUNCTION

DEPRESSION

PMS & MENOPAUSAL SYMPTOMS

TESTOSTERONE IMBALANCE

Reasearch On Nutramedix Product

Medical Conditions [peer-reviewed journals]

Human Influenza Virus (HIV)

del Valle Mendoza, J., Pumarola, T., Gonzales, L. A., & Del Valle,L. J. (2014). Antiviral activity of maca (Lepidium meyenii) against human influenza virus. Asian Pacific journal of tropical medicine, 7, S415-S420. Full Article

Menopausal symptoms

Lee, M. S., Shin, B. C., Yang, E. J.,Lim, H. J., & Ernst, E. (2011). Maca (Lepidium meyenii) for treatment of menopausal symptoms: a systematic review. Maturitas,70(3), 227-233. Full Article

Cancer

Zahra, K., & KESHTMAND, Z.(2018). Protective Effects of Tribulusterrestris Hydroalcoholic Extract Against Cisplatin-Induced Germ Cell Apoptosis in Male Mice. International Journal of Morphology, 36(1), 140-145. Full Article

Thu, H. E., Hussain, Z., Mohamed, I.N., & Shuid, A. N. (2018). Eurycomalongifolia, a potential phytomedicine for the treatment of cancer: Evidence of p53-mediated apoptosis in cancerous cells. Current drug targets, 19(10),1109-1126. Full Article

Coccidiosis

Hong, S., Moon, M. N., Im, E. K.,Won, J. S., Yoo, J. H., & Kim, O. (2018). Anti-coccidial activity of the ethanol extract of Tribulus terrestris fruits on Eimeria tenella. Laboratory animal research, 34(1), 44-47. Full Article

Erectile Dysfunction

Do, J., Choi, S., Choi, J., & Hyun, J. S. (2013). Effects and mechanism of action of a Tribulus terrestris extract on penile erection. Korean journal of urology,54(3), 183-188. Full Article

Zenico, T., Cicero, A. F. G., Valmorri, L., Mercuriali, M., & Bercovich, E. (2009). Subjective effects of Lepidium meyenii (Maca) extract on well‐being and sexual performances inpatients with mild erectile dysfunction: a randomised, double‐blind clinical trial. Andrologia, 41(2), 95-99. Full Article

Medicinal Properties [peer-reviewed journals]

Immunomodulatory

Wang, W., Zou, Y., Li, Q., Mao, R.,Shao, X., Jin, D., ... & Yang, L. (2016). Immunomodulatory effects of a polysaccharide purified from Lepidiummeyenii Walp. on macrophages. Process Biochemistry, 51(4), 542-553. Full Article

Antioxidant

Korkmaz, S. (2018). Antioxidants in Maca (Lepidium meyenii) as a Supplement in Nutrition. In Antioxidants in Foods and Its Applications. IntechOpen. Full Article

Wang, W., Zhang, F., Li, Q., Chen, H., Zhang, W., Yu, P., ...& Wu, X. (2018). Structure characterization of one polysaccharide from Lepidium meyenii Walp., and its antioxidant activity and protective effect against H2O2-induced injury RAW264.7 cells. International Journal of Biological Macromolecules, 118, 816-833. Full Article

Caicai, K., Limin, H., Liming, Z., Zhiqiang, Z., & Yongwu, Y. (2018).Isolation, purification and antioxidant activity of polysaccharides from the leaves of maca (Lepidium Meyenii). International Journal of Biological Macromolecules, 107, 2611-2619. Full Article

Lin, L., Huang, J., Sun‐Waterhouse, D., Zhao, M., Zhao, K., &Que, J. (2018). Maca (Lepidium meyenii) as a source of macamides and polysaccharide in combating of oxidative stress and damage in human erythrocytes. International Journal of Food Science & Technology, 53(2), 304-312. Full Article

Zha, S., Zhao, Q., Chen, J., Wang, L., Zhang, G., Zhang, H., &Zhao, B. (2014). Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii). Carbohydrate Polymers, 111, 584-587. Full Article

Večeřa, R., Orolin, J., Škottová, N., Kazdová, L., Oliyarnik, O.,Ulrichová, J., & Šimánek, V. (2007). The influence of maca (Lepidium meyenii) on antioxidant status, lipid and glucose metabolism in rat. Plant Foods for Human Nutrition, 62(2), 59-63. Full Article

Sandoval, M., Okuhama, N. N., Angeles, F. M., Melchor, V. V.,Condezo, L. A., Lao, J., & Miller, M. J. (2002). Antioxidant activity of the cruciferous vegetable Maca (Lepidiummeyenii). Food Chemistry, 79(2), 207-213. Full Article

Hormone Regulator

Sanchez‐Salazar, L.,& Gonzales, G. F. (2018). Aqueous extract of yellow maca (Lepidium meyenii) improves sperm count in experimental animals but response depends on hypocotyl size, pH and routes of administration. Andrologia, 50(3), e12929. Full Article

Gonzales, G. F.,Gasco, M., Cordova, A., Chung, A., Rubio, J., & Villegas, L. (2004). Effect of Lepidium meyenii (Maca) on spermatogenesis in male rats acutely exposed to high altitude (4340 m). Journal of Endocrinology, 180(1), 87-95. Full Article

Oshima, M., GU, Y., & Tsukada, S. (2003). Effects of Lepidium meyenii Walp and Jatropha macrantha on blood levels of estradiol-17 β, progesterone, testosterone and the rate of embryo implantation in mice. Journal of Veterinary Medical Science, 65(10),1145-1146. Full Article

Sperm Count

Gonzales, G. F., Nieto, J., Rubio, J., & Gasco, M. (2006). Effect of Black maca (Lepidium meyenii) on one spermatogenic cycle in rats. Andrologia, 38(5), 166-172. Full Article

Bustos‐Obregón, E., Yucra, S., & Gonzales, G. F. (2005). Lepidium meyenii (Maca) reduces spermatogenic damage induced by a single dose of malathion in mice. Asian Journal of Andrology, 7(1), 71-76. Full Article

Gonzales, G. F., Cordova, A., Gonzales, C., Chung, A., Vega, K.,& Villena, A. (2001). Lepidiummeyenii (Maca) improved semen parameters in adult men. Asian Journal of Andrology, 3(4), 301-304. Full Article

Sexual Behavior

Brooks, N. A., Wilcox, G., Walker, K. Z., Ashton, J. F., Cox, M.B., & Stojanovska, L. (2008). Beneficial effects of Lepidium meyenii (Maca) on psychological symptoms and measures of sexual dysfunction in postmenopausal women are not related to estrogen or androgen content. Menopause, 15(6), 1157-1162. Full Article

Lentz, A., Gravitt, K., Carson, C. C., & Marson, L. (2007). Acute and chronic dosing of Lepidiummeyenii (Maca) on male rat sexual behavior. The Journal of Sexual Medicine,4(2), 332-340. Full Article

Rubio, J., Riqueros, M. I., Gasco, M., Yucra, S., Miranda, S.,& Gonzales, G. F. (2006). Lepidiummeyenii (Maca) reversed the lead acetate induced—damage on reproductive function in male rats. Food and Chemical Toxicology, 44(7), 1114-1122. Full Article

Gonzales, G. F., Cordova, A., Vega, K., Chung, A., Villena, A.,& Góñez, C. (2003). Effect of Lepidium meyenii (Maca), a root with aphrodisiac and fertility-enhancing properties, on serum reproductive hormone levels in adult healthy men. Journal of Endocrinology, 176(1), 163-168. Full Article

Gonzales, G. F., Rubio, J., Chung, A., Gasco, M., & Villegas,L. (2003). Effect of alcoholic extract of Lepidium meyenii (Maca) on testicular function in male rats. Asian Journal of Andrology, 5(4), 349-349. Full Article

Gonzales, G. F., Cordova, A., Vega, K., Chung, A., Villena, A.,Góñez, C., & Castillo, S. (2002). Effect of Lepidium meyenii (MACA) on sexual desire and its absent relationship with serum testosterone levels in adult healthy men. Andrologia, 34(6), 367-372. Full Article

Cicero, A. F.,Bandieri, E., & Arletti, R. (2001). Lepidium meyenii Walp. improves sexual behaviour in male rats independently from its action on spontaneous locomotor activity. Journal of Ethnopharmacology,75(2-3), 225-229. Full Article

Hooi Hoon, A. N. G., Cheang, H. S., & Yusof, A. P. M. (2000). Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Exp. Anim, 49(1), 35-38. Full Article

Zheng, B. L., He, K., Kim, C. H., Rogers, L., Shao, Y. U., Huang,Z. Y., ... & Zheng, Q. Y. (2000). Effect of a lipidic extract from Lepidium meyenii on sexual behavior in mice and rats. Urology, 55(4), 598-602. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

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Conference Presentations

Patient Reports

Dosage Information

Take 20-30 drops in 4 oz. of water two to three times daily.

Protocols

Safety Information

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MACA
Lepidium meyenii: Hormone Regulator (Yellow)

Lepidium meyenii (Maca) is a plant of the Brassicaceae family that grows between 4,000 and 4,500 metres above sea level (m.a.s.l.) in the Peruvian Central Andes, particularly in Junin and Pasco. Maca grows in these places in the range of temperatures from a maximum of 12°C to a minimum of 1.5°C. This range of temperatures occurs in the Central Andes because of its proximity to the equator.

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Lepidium meyenii: Antioxidant (Supplement)

Antioxidant effects of plants used in daily nutrition are investigated, their bioactive contents are analyzed and its mechanisms are revealed. Recently, bioactive compounds with antioxidant effects have been found in many plants traditionally used. These plants cross their local region, cultivated in many parts of the world, and take place in markets as various supplement products.

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Lepidium meyenii: Antioxidant (structure)

Lepidium meyeniiWalp. (Maca) belonging to the Brassicaceae is a perennial herbaceous plant native to South America, it grows under low temperature and high altitude varying between 3700 and 4450 m. Maca, as a food source, possesses high nutritive value and is rich in starches, proteins, minerals and sugars.

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Lepidium meyenii: Antioxidant (Macamides)

Maca is known to be rich in macamides. The objective of this study was to analyse macamide profiles of macas with different colours cultivated in Yunnan, China, and commercial Peru maca by ultra-highperformance liquid chromatography–tandem mass spectrometry.

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Lepidium meyenii: Antioxidant (Isolation)

Maca (Lepidium meyenii), an annual or biennial plant of family of Brassicaceae, mainly grows in the Andes region of Peru where the altitude is between 3500 and 4500 m above sea level. This area is characterized by freezing temperature, intense sunlight, fierce winds, barren, androcky terrain.

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Lepidium meyenii: Coccidiosis (fruits)

Coccidiosis is an infectious disease by protozoa Eimeria and an important parasitic zoonotic disease. It induced severe losses of mortality, morbidity in the poultry industry. In addition, a lot of anti-coccidial medications to prevent Eimeria infection have revealed the decreased efficacy because some Eimeria species have developed resistance activity to anti-coccidials.

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Lepidium meyenii: Cancer (protective)

Cisplatin (cis-Diamminedichloroplatinum (II): CDDP) is actually one of the most widely used anticancer drugs, and the central role of this drug in human cancer chemotherapy aTTests to its current importance.

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Lepidium meyenii: Cancer (p53)

This review was aimed to critically analyze the therapeutic viability and anticancer efficacy of Eurycoma longifolia in the treatment of cancer and also to propose its molecular and translational mechanism of cytotoxicity against cancerous cells.

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Lepidium meyenii: Menopausal

Maca (Lepidium meyenii), an Andean plant of the brassica (mustard) family has been used for centuries in the Andes as an adaptogenic plant to manage anemia, infertility and female hormone balance. The aim of this review was to assess the evidence for and against the effectiveness of the maca plant as a treatment for menopausal symptoms.

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Lepidium meyenii: Sperm Count

Aim: To observe the effect of the aqueous extract of hypocotyls of the plant Lepidium meyenii (Maca) on spermatogenic damage induced by the organophosphate insecticide malathion in mice.

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Lepidium meyenii: Sperm Count (cycle)

Lepidium meyenii (Maca) grows exclusively between 4000 and 4500 m above sea level in the Peruvian central Andes. The hypocotyls of this plant are traditionally used in the Andean region for their supposed fertility-enhancing properties.

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Lepidium meyenii: Sexual Behavior (spontatneous)

The aim of the present study is to determine the effect of acute and chronic oral administration of a purified extract from L. meyenii root on male rats sexual performances and spontaneous locomotion.

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Lepidium meyenii: Sexual Behavior (serum)

Lepidium meyenii (Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m in the central Andes. Maca is traditionally employed in the Andean region for its supposed aphrodisiac and/or fertility-enhancing properties.

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Lepidium meyenii: Sexual Behavior (postmenopausal))

Objective: To examine the estrogenic and androgenic activity of Lepidium meyenii (Maca) and its effect on the hormonal profile and symptoms in postmenopausal women.

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Lepidium meyenii: Sexual Behavior (lipid)

Objectives: To determine the effect of oral administration of a purified lipidic extract from Lepidium meyenii (MacaPure M-01 and M-02) on the number of complete intromissions and mating in normal mice, and on the latent period of erection (LPE) in rats with erectile dysfunction.

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Lepidium meyenii: Sexual Behavior (damage)

Rats were treated with 0, 8, 16 and 24 mg/kg of lead acetate (LA) (i.p.) for 35 days with or without Maca. Maca was co-administrated orally from day 18 to day 35. The lengths of stages of the seminiferous epithelium were assessed by transillumination.

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Lepidium meyenii: Sexual Behavior (acute and C)

The use of natural remedies for the treatment of sexual disorders is under current investigation. For generations people of the rural community in Peru have used Lepidium meyenii Walpers (Maca), because of their belief that it improves fertility and sexual desire.

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Lepidium meyenii: Sexual Behavior (absent)

This study was a 12-week double blind placebo-controlled, randomized, parallel trial in which active treatment with different doses of Maca Gelatinizada was compared with placebo. The study aimed to demonstrate if effect of Maca on subjective report of sexual desire was because of effect on mood or serum testosterone levels.

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Lepidium meyenii: Immunomodulatory

A polysaccharide (MP21) was extracted and purified from Lepidium meyenii Walp. using DEAE-52 and SephacrylTM S-500 columns. Its physicochemical properties and macrophage immunomodulatory activity were investigated in vitro. T

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Lepidium meyenii: Hormone Regulator

The effects of two Peruvian folk medicines, Lepidium meyenii Walp and Jatropha macrantha, on mouse sex steroid hormones and embryo implantation were investigated. Progesterone levels increased significantly in mice that received L. meyenii Walp, while testosterone levels increased significantly in mice that received L. meyenii Walp as well as in those that received both L. meyenii Walp and J. macrantha.

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Lepidium meyenii: Hormone Regulator (spermatogenesis)

Lepidium meyenii (Maca) is a Peruvian hypocotyl that grows exclusively between 4000 and 4500 m in the central Andes. Maca is traditionally employed in the Andean region for its supposed fertility-enhancing properties.

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Lepidium meyenii: HIV

Objective: To investigate antiviral activity of maca to reduce viral load in Madin-Darby canine kidney (MDCK) cells infected with influenza type A and B viruses (Flu-A and Flu-B, respectively).

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Lepidium meyenii: ED

Lepidium meyenii (Maca) is a cultivated root belonging to the brassica family used in the Andean region for its supposed aphrodisiac properties. We carried out a double-blind clinical trial on 50 Caucasian men affected by mild erectile dysfunction (ED), randomised to treatment with Maca dry extract, 2400 mg, or placebo.

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Lepidium meyenii: Antioxidant

Maca (Lepidium meyenii) is a plant from the Andes of Peru. Maca is used as a food for its nutritional value and ethnomedicinal properties linked to fertility and vitality. The purpose of this study was to evaluate the antioxidant activity of Maca. For all experiments an aqueous extract of Maca was used.

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Lepidium meyenii: Antioxidant (purification)

Water-soluble polysaccharides were separated from maca (Lepidium meyenii) aqueous extract (MAE). The crude polysaccharides were deproteinized by Sevag method. During the preparation process of maca polysaccharides, amylase and glucoamylase effectively removed starch in maca polysaccharides.

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Lepidium meyenii: Antioxidant (glucose)

This work focused on the effect of maca on lipid, anti-oxidative, and glucose parameters in hereditary hypertriglyceridemic (HHTg) rat. Maca (1%) was administred to rats as a part of a high-sucrose diet (HSD) for 2 weeks. Rosiglitazone (0.02%) was used as a positive control.

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