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General Description

Barberry is an extract produced from the root of Mahonia aquifolium, commonly known as Oregon Grape Root. The Mayo Clinic in 1999 published research proving that chronic sinusitis is caused by an underlying fungus in the sinuses with a superimposed bacterial infection. Only the acute superimposed bacterial infection is eliminated when a patient is treated with a standard pharmaceutical antibacterial; the underlying chronic fungal infection in the sinuses is not addressed. BARBERRY addresses both the bacterial and fungal infections. Many patients that have asthma and bronchospastic disease have chronic sinusitis and/or chronic bronchitis as an underlying cause. Since BARBERRY addresses the underlying infectious causes so well, it usually helps resolve the bronchospasm and asthma. Many practitioners have also found that atherosclerotic disease appears to be primarily an infectious disease caused by bacteria, fungi and sometimes viruses; those practitioners have found BARBERRY to be very helpful in resolving the infection which then causes atherosclerosis to diminish and resolve. BARBERRY effectively treats Chlamydia pneumonia, mycoplasma, many herpes viruses of different types and mucor; peer-reviewed literature states that all of these are known to contribute to atherosclerotic disease.

Some Reported Medicinal Properties













Research On NutraMedix Product

Medical Conditions [peer-reviewed journals]

Atopic dermatitis

Klövekorn, W., Tepe, A., & Danesch, U. (2007). A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis. International Journal of Clinical Pharmacology and Therapeutics, 45(11), 583-591. Full Article


Bernstein, S., Donsky, H., Gulliver, W., Hamilton, D., Nobel, S., & Norman, R. (2006). Treatment of mild to moderate psoriasis with Relieva, a Mahonia aquifolium extract—a double-blind, placebo-controlled study. American Journal of Therapeutics, 13(2), 121-126. Full Article

Wiesenauer, M., & Lüdtke, R. (1996). Mahonia aquifolium in patients with Psoriasis vulgaris—an intraindividual study. Phytomedicine, 3(3), 231-235. Full Article

Atopic Dermatitis

Donsky, H., & Clarke, D. (2007). Relieva, a Mahonia aquifolium extract for the treatment of adult patients with atopic dermatitis. American Journal of Therapeutics, 14(5), 442-446. Full Article


Damjanović, A., Zdunić, G., Šavikin, K., Mandić, B., Jadranin, M., Matić, I. Z., & Stanojković, T. (2016). Evaluation of the anti-cancer potential of Mahonia aquifolium extracts via apoptosis and anti-angiogenesis. Bangladesh J Pharmacol, 11, 741-749. Full Article

Čerňáková, M., Košt'álová, D., Kettmann, V., Plodová, M., Tóth, J., & Dřímal, J. (2002). Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. BMC complementary and alternative medicine, 2(1), 2. Full Article

Medicinal Properties [peer-reviewed journals]


Coklar, H., & Akbulut, M. (2017). Anthocyanins and phenolic compounds of Mahonia aquifolium berries and their contributions to antioxidant activity. Journal of Functional Foods, 35, 166-174. Full Article

Pyrkosz-Biardzka, K., Kucharska, A. Z., Sokół-Łętowska, A., Strugała, P., & Gabrielska, J. (2014). A comprehensive study on antioxidant properties of crude extracts from fruits of Berberis vulgaris L., Cornus mas L. and Mahonia aquifolium Nutt. Polish Journal of Food and Nutrition Sciences, 64(2), 91-99. Full Article

Kumaraswamy, M. V., & Satish, S. (2008). Free radical scavenging activity and lipoxygenase inhibition of Woodfordia fructicosa Kurz and Betula utilis Wall. African Journal of Biotechnology, 7(12), 2013-2016. Full Article

Račková, L., Májeková, M., Košt’álová, D., & Štefek, M. (2004). Antiradical and antioxidant activities of alkaloids isolated from Mahonia aquifolium. Structural Aspects. Bioorganic & Medicinal Chemistry, 12(17), 4709-4715. Full Article

Müller, K., & Ziereis, K. (1994). The antipsoriatic Mahonia aquifolium and its active constituents; I. Pro-and antioxidant properties and inhibition of 5-lipoxygenase. Planta Medica, 60(05), 421-424. Full Abstract


Volleková, A., Košt'álová, D., Kettmann, V., & Tóth, J. (2003). Antifungal activity of Mahonia aquifolium extract and its major protoberberine alkaloids. Phytotherapy Research, 17(7), 834-837. Full Article


Andreicuţ, A. D., Parvu, A. E., Moț, A. C., Parvu, M., FISCHER-FODOR, E. V. A., VASILE FELDRIHAN, A. F., ... & IRIMIE, A. (2018). Anti-inflammatory and antioxidant effects of Mahonia aquifolium leaves and bark extracts. Farmacia, 66(1). Full Article

Antimutagenic activity

Čerňáková, M., Košt'álová, D., Kettmann, V., Plodová, M., Tóth, J., & Dřímal, J. (2002). Potential antimutagenic activity of berberine, a constituent of Mahonia aquifolium. BMC Complementary and Alternative Medicine, 2(1), 2. Full Article


Rohrer, U., Kunz, E. M., Lenkeit, K., Schaffner, W., & Meyer, J. (2007). Antimicrobial activity of Mahonia aquifolium and two of its alkaloids against oral bacteria. Schweizer Monatsschrift fur Zahnmedizin= Revue mensuelle suisse d'odonto-stomatologie= Rivista mensile svizzera di odontologia e stomatologia, 117(11), 1126-1131. Full Abstract

Slobodníková, L., KoSt'álová, D., Labudová, D., Kotulová, D., & Kettmann, V. (2004). Antimicrobial activity of Mahonia aquifolium crude extract and its major isolated alkaloids. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 18(8), 674-676. Full Article


Kardošová, A., Malovı́ková, A., Pätoprstý, V., Nosal'Ova, G., & Matáková, T. (2002). Structural characterization and antitussive activity of a glucuronoxylan from Mahonia aquifolium (Pursh) Nutt. Carbohydrate Polymers, 47(1), 27-33. Full Article


Galle, K., Müller-Jakic, B., Proebstle, A., Jurcic, K., Bladt, S., & Wagner, H. (1994). Analytical and pharmacological studies on Mahonia aquifolium. Phytomedicine, 1(1), 59-62. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]


Conference Presentations

Patient Reports

"Once I turned 21, I was crippled by chronic sinusitis.  7 years of my life were spent sick, on antibiotics and steroids.  Barberry changed all that and wiped out my sinus infections and I'm now healthy and living my life to the fullest!"-M.Z.

“I don't know what you do to this herb but it's the best barberry I've ever seen. If anyone wants barberry I say don't waste your money on any other brand. I promise you they're not as good. I know. I tried them all.” – M.S

“This has been a great extract to use for P.A.N.D.A.S and it has lessened the severity of my daughter's tics.” – P.N

"Barberry helped me with getting over a urinary tract infection.  It lasted almost 2 months.  The meds that the doctor gave me didn't work, but after one full day of Barberry, it was GONE. " -O.M.

Dosage Information

15 to 30 drops in 4 oz. of water 30 minutes before a meal twice daily.


Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Barberry did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.

Product Label

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Barberry: Anti-inflammatory (Leaves)

Oxidative stress and inflammation are interlinked processes that seem to play an important role in aging. The present work aimed to test the antioxidant and anti-inflammatory activity of ethanolic Mahonia aquifolium leaves and bark extracts in an experimental acute inflammation.

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Barberry: Psoriasis

Psoriasis is a common skin disorder that affects more than 4.5 million people in North America. Treatment of psoriasis is problematic because the severity and distribution of psoriatic plaques varies immensely. Localized psoriasis can often respond to topical medications, of which steroid and vitamin D analogue creams such as calcipotriol, anthralin, coal tar, and ultraviolet light treatments are the most common.

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Barberry: Psoriasis (vulgaris)

A topical long-term treatment is for the most part unavoidable, since most psoriasis patients have to deal with their disease all life long. Therefore, it seems reasonable to look for new treatment strategies that would reduce the amount of risky medication.

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Barberry: Immunomodulating

Alcoholic extracts of the antipsoriatic Mahonia aquifolium drug which were analysed for the irqualitative and quantitative alkaloid content, showed an in vitro inhibiting effect on cyclooxygenase (CO) of sheep seminal vesicles and 5-lipoxygenase (5-LO) of porcine leucocytes.

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Barberry: Cancer

As part of a study aimed at developing new pharmaceutical products from natural resources, the purpose of this research was twofold: to fractionate crude extracts from the bark of Mahonia aquifolium and to evaluate the strength of the antimutagenic activity of the separate components against one of the common direct-acting chemical mutagens.

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Barberry: Atopic Dermatitis

Atopic dermatitis is a common health problem that affects 15 million people in the United States. It usually begins in infancy, affecting 10% to 17% of children. Atopic dermatitis will improve in approximately50% of these children by the time they are between 5 and 15 years of age.

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Barberry: Atopic Dermatitis (randomized)

Atopic dermatitis is a chronic inflammatory disease of the skin which can significantly affect a patient’s health and well-being. Approximately 10 – 20% of children and 1 – 3% of adults are affected. The most common symptoms of atopic dermatitis are pruritus and erythema.

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Barberry: Antitussive

Mahonia aquifolium (Pursh) Nutt. from the Berberidacea family is a shrub widespread in the forests of the North American Pacific coast and is known also as a cultivated plant in gardens and parks called mahonia.

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Barberry: Antioxidant (free rad)

Mahonia root and stem bark have long been considered to have anti-inflammatory, anti-bacterial, anti-fungal activity and they are used particularly for treatment of skin diseases. They are indicated for treatment of the eczema, psoriasis, and other skin conditions.

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Barberry: Antioxidant (Crude)

The antioxidant capacity of methanolic crude extracts of Berberis vulgaris L., Cornus mas L. and Mahonia aquifolium Nutt. was tested with the thiobarbituric acid reactive substances formation assay, the ferric reducing power (FRAP) and 2,2-diphenyl-2-picrylhydrazyl (DPPH•) radical scavenging assay.

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Barberry: Antioxidant (berries)

Mahonia aquifolium is an invasive woody evergreen shrub with sweet smelling bright yellow flowers that bloom in April. It has red-colored fruits that are often referred to as Oregon grapes. It is native to western North America, but it has spread to other areas of America, Australia and Europe and is used for landscaping and medicinal purposes.

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Barberry: Antioxidant (antirad)

Berberine and berberine-type alkaloids representing a structural class of organic cations, produced in numerous plants of the genera Berberis, Mahonia, and Coptis, have been shown to exert a broad spectrum of antimicrobial, anticancerogenic, and antimutagenic activity.

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Barberry: Antimutagenic

Traditional Chinese medicine has been practised by Chinese communities world-wide for many generations, and there is a wealth of literature information available related to the therapeutic use of this type of medicine. In recent years, there has been a global surge in the popularity of herbal/traditional medicine, and currently there is enormous interest in developing new pharmaceutical products from such resources.

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Barberry: Antimicrobial

The crude extract of Mahonia aquifolium (Pursh) Nutt. stem bark and its two main protoberberine alkaloids, berberine and jatrorrhizine, were tested for their in vitro antimicrobial activity. Twenty strains of coagulasenegative staphylococci and 20 strains of Propionibacterium acnes isolated from skin lesions of patients with a severe form of acne, and 20 strains of Candida sp. isolated from chronic vulvovaginal candidoses were tested for their susceptibility to crude extract and two isolated alkaloids.

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Barberry: Antifungal

The crude extract of Mahonia aquifolium (Berberidaceae) stem bark and its components berberine, palmatine and jatrorrhizine were screened for their inhibitory activity against a variety of dermatophytes and two Candida species of human origin using the in vitro dilution agar plate method.

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Barberry: Anti-inflammatory

Oxidative stress and inflammation are interlinked processes that seem to play an important role in aging. The present work aimed to test the antioxidant and anti-inflammatory activity of ethanolic Mahonia aquifolium leaves and bark extracts in an experimental acute inflammation.

Download PDFRead more