UP

CHANCA PIEDRA

STONE BREAKER

TO RESOLVE:

  • KIDNEY STONES/GALLSTONES
  • OBSESSIVE COMPULSIVE DISORDER (OCD)
  • INFECTIONS FROM SOME PARASITES,
  • BACTERIA AND VIRUSES
Download PDF

General Description

Glucomedix Pitch Deck

Chanca Piedra –Stone Breaker is an extract produced from the leaves and stems of the Chanca Piedra (Phyllanthus niruri) plant that is found in South America.  Chanca Piedra has been used for generations by the indigenous population of South America in eliminating gallstones and kidney stones, reducing pain and spasms associated with these stones and treating malaria, colds, flu and certain other infections. Anecdotal reports in humans suggest Chanca Piedra also has anti-Babesia and anti-OCD properties.

Some Reported Medicinal Properties

ANTIVIRAL

ANTIFUNGAL

ANTIBACTERIAL

ANTISPASMODIC

ANTIMUTAGENIC

DIURETIC

HYPOGLYCEMIC

ANTILITHIC

ANALGESIC

ANTIMALARIAL

HEPATOPROTECTIVE

Research On NutraMedix Product

Medical Conditions [peer-reviewed journals]

DENGUE VIRUS

Suresh, U., Murugan, K., Benelli, G., Nicoletti, M., Barnard, D. R., Panneerselvam, C., ... & Chandramohan, B. (2015). Tackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae). Parasitology Research, 114(4), 1551-1562. Full Article

DIABETES

Mediani, A., Abas, F., Maulidiani, M., Khatib, A., Tan, C. P., Ismail, I. S., ... & Lajis, N. H. (2016). Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract.Journal of Pharmaceutical and Biomedical Analysis, 128, 302-312. Full Article

Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., & Salawu, O. A. (2011). Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharmaceutical Biology, 49(3), 248-255. Full Article

Okoli, C. O., Ibiam, A. F., Ezike, A. C., Akah, P. A., & Okoye, T. C. (2010). Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats. African Journal of Biotechnology, 9(2). Full Article

Bavarva, J. H., & Narasimhacharya, A. V. R. L. (2007). Comparative Antidiabetic, Hypolipidemic, and Antioxidant Properties of Phyllanthus niruri. in Normal and Diabetic Rats. Pharmaceutical Biology, 45(7), 569-574. Full Article

Cancer

Yuniati, Y., Yuliati, L., Monica, E., & Rollando, R. (2019,April). Discovering anticancer compound of ethyl acetate extract from RL1 code endophytic fungi culture derived by Phyllanthus niruri Linn leaves through cell cycle modulation in T47d cells. In IOP Conference Series: Materials Science and Engineering(Vol. 509, No. 1, p.012157). IOP Publishing. Full Article

Cao, X., Xing, X., Wei, H., Lu, W., & Wei, W. (2018). Extraction method and anti-cancer evaluation of two lignans from Phyllanthus Niruri L. Medicinal Chemistry Research, 27(8), 2034-2041. Full Article

HEPATITIS B

Liu, S., Wei, W., Li, Y., Lin, X., Shi, K., Cao, X., & Zhou, M. (2014). In vitro and in vivo anti-hepatitis B virus activities of the lignan nirtetralin B isolated from Phyllanthus niruri L. Journal of Ethnopharmacology, 157, 62-68. Full Article

Wei, W., Li, X., Wang, K., Zheng, Z., & Zhou, M. (2012). Lignans with Anti‐Hepatitis B Virus Activities from Phyllanthus niruri L. Phytotherapy Research, 26(7), 964-968. Full Article

HIV

Naik, A. D., & Juvekar, A. R. (2003). Effects of alkaloidal extract of Phyllanthus niruri on HIV replication. Indian Journal of Medical Sciences, 57(9), 387-393. Full Article

Kidney Function

 Giribabu, N., Karim, K., Kilari, E. K., &Salleh, N. (2017). Phyllanthus niruri leaves aqueous extract improves kidney functions, ameliorates kidney oxidative stress, inflammation, fibrosis and apoptosis and enhances kidney cell proliferation in adult male rats with diabetes mellitus. Journal of ethnopharmacology, 205, 123-137. Full Article

LIVER CIRRHOSIS

Amin, Z. A., Bilgen, M., Alshawsh, M. A., Ali, H. M., Hadi, A. H. A., & Abdulla, M. A. (2012). Protective role of Phyllanthus niruri extract against thioacetamide-induced liver cirrhosis in rat model. Evidence-Based Complementary and Alternative Medicine, 2012. Full Article

UROLITHIASIS (KIDNEY STONES)

Boim, M. A., Heilberg, I. P., & Schor, N. (2010). Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. International Braz J Urol, 36(6), 657-664. Full Article

MALARIA

Tona, L., Mesia, K., Ngimbi, N. P., Chrimwami, B., Okond'Ahoka, Cimanga, K., ... & Pieters, L. (2001). In-vivo antimalarial activity of Cassia occidentalism Morinda morindoides and Phyllanthus niruri. Annals of Tropical Medicine & Parasitology, 95(1), 47-57. Full Article

TUMORS

Sharma, P., Parmar, J., Verma, P., Sharma, P., & Goyal, P. K. (2009). Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac J Cancer Prev, 10(6), 1089-1094. Full Article

Medicinal Properties [peer-reviewed journals]

ANTIBACTERIAL

Ekwenye, U. N., & Njoku, N. U. (2006). Antibacterial effect of Phyllanthus niruri (Chanca Piedra) on three enteropathogens in Man. International Journal of Molecular Medicine and Advance Sciences, 2(2), 184-189. Full Article

ANTIHYPERURICEMIC

Murugaiyah, V., & Chan, K. L. (2009). Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. Journal of Ethnopharmacology, 124(2), 233-239. Full Article

ANTIOXIDANT

Navarro, M., Moreira, I., Arnaez, E., Quesada, S., Azofeifa, G., Alvarado, D., & Monagas, M. J. (2017). Proanthocyanidin Characterization, Antioxidant and Cytotoxic Activities of Three Plants Commonly Used in Traditional Medicine in Costa Rica: Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd. Plants, 6(4), 50. Full Article

Sabir, S. M., & Rocha, J. B. T. (2008). Water-extractable phytochemicals from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice. Food Chemistry, 111(4), 845-851. Full Article

Bhattacharjee, R., & Sil, P. C. (2007). Protein isolate from the herb, Phyllanthus niruri L.(Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food and Chemical Toxicology, 45(5), 817-826. Full Article

Chatterjee, M., Sarkar, K., & Sil, P. C. (2006). Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Pathophysiology, 13(2), 95-102. Full Article

Chatterjee, M., & Sil, P. C. (2006). Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian Journal of Biochemistry & Biophysics, 43, 299-305. Full Article

Bhattacharjee, R., & Sil, P. C. (2006). The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(7), 595-601. Full Article

Harish, R., & Shivanandappa, T. (2006). Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chemistry, 95(2), 180-185. Full Article

ANTIMICROBIAL

Ranilla, L. G., Apostolidis, E., & Shetty, K. (2012). Antimicrobial activity of an Amazon medicinal plant (Chanca piedra) (Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria. Phytotherapy Research, 26(6), 791-799. Full Article

Mahalakshmi, N., Dhanasekaran, S., Ravi, C., & Lingathurai, S.(2016). In-vitro antimicrobial activities of Pongamia glabra and Phyllanthus niruri. South Indian Journal of Biological Sciences2(2),236-244. Full Article

Rollando, R., Notario, D., Eva, M.,Aditya, M., & Sitepu, R. (2017). Antimicrobial, antioxidant, and cytotoxic activities of end hopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies. The Journal of Pure and Applied Chemistry Research, 6(1), 64. Full Article

 Sunitha, J., Krishna, S., Ananthalakshmi, R., Jeeva, J. S.,Girija, A. S., & Jeddy, N. (2017). Antimicrobial Effect of Leaves of Phyllanthus niruri and Solanum nigrum on Caries Causing Bacteria: An In vitro Study. Journal of clinical and diagnostic research: JCDR, 11(6),KC01. Full Article

ANTI-INFLAMMATORY

Mostofa, R., Ahmed, S., Begum, M. M., Rahman, M. S., Begum, T., Ahmed, S. U., ... & Begum, R. (2017). Evaluation of anti-inflammatory and gastric anti-ulcer activity of Phyllanthus niruri L.(Euphorbiaceae) leaves in experimental rats. BMC complementary and alternative medicine, 17(1), 267. Full Article

ANTIPLASMODIAL

Ifeoma, O., Samuel, O., Itohan, A. M., & Adeola, S. O. (2013). Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pacific Journal of Tropical Medicine, 6(3), 169-175. Full Article

Soh, P. N., Banzouzi, J. T., Mangombo, H., Lusakibanza, M., Bulubulu, F. O., Tona, L., ... & Luyindula, S. N. (2009). Antiplasmodial activity of various parts of Phyllanthus niruri according to its geographical distribution. African journal of Pharmacy and Pharmacology, 3(12), 598-601. Full Article

Mustofa, S. E., & Wahyuono, S. (2007). In vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of Phyllanthus niruri L. herbs traditionally used to treat malaria in Indonesia. Southeast Asian J Trop Med Public Health, 38(4), 609-615. Full Article

Cimanga, R. K., Tona, L., Luyindula, N., Mesia, K., Lusakibanza, M., Musuamba, C. T., ... & Totté, J. (2004). In vitro antiplasmodial activity of callus culture extracts and fractions from fresh apical stems of Phyllanthus niruri L.(Euphorbiaceae): part 2. Journal of Ethnopharmacology, 95(2-3), 399-404. Full Article

Antifungal

 Ajibade, V. A., Ajenifuja, O. A., Akinruli, F. T., Ajayi, F. A.,& Famurewa, O. (2018). Antifungal efficacy of saponin extracted from Phyllanthus niruri. International Journal of Pathogen Research, 1-8. Full Article

HEPATOPROTECTIVE

Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236-243. Full Article

IBS

Giribabu, N., Rao, P. V., Kumar, K. P., Muniandy, S., Swapna Rekha, S., & Salleh, N. (2014). Aqueous extract of Phyllanthus niruri leaves displays in vitro antioxidant activity and prevents the elevation of oxidative stress in the kidney of streptozotocin-induced diabetic male rats. Evidence-Based Complementary and Alternative Medicine, 2014. Full Article

IMMUNOMODULATING

Nworu, C. S., Akah, P. A., Okoye, F. B. C., Proksch, P., & Esimone, C. O. (2010). The effects of Phyllanthus niruri aqueous extract on the activation of murine lymphocytes and bone marrow-derived macrophages.Immunological investigations, 39(3), 245-267. Full Article

Muthulakshmi, M., Subramani, P. A., & Michael, R. D.(2016). Immunostimulatory effect of the aqueous leaf extract of Phyllanthus niruri on the specific and nonspecific immune responses of Oreochromis mossambicus Peters. Iranian journal of veterinary research, 17(3), 200. Full Article

VARIOUS PROPERTIES

Amin, Z. A., Abdulla, M. A., Ali, H. M., Alshawsh, M. A., & Qadir, S. W. (2012). Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri. Journal of the Science of Food and Agriculture, 92(9), 1874-1877. Full Article

Bagalkotkar, G., Sagineedu, S. R., Saad, M. S., & Stanslas, J. (2006). Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. Journal of Pharmacy and Pharmacology, 58(12), 1559-1570. Full Article

Lee, N. Y., Khoo, W. K., Adnan, M. A., Mahalingam, T. P.,Fernandez, A. R., & Jeevaratnam, K. (2016). The pharmacological potential of Phyllanthus niruri. Journal of Pharmacy and Pharmacology, 68(8), 953-969. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Patient Reports

"My daughter was turning 37 and wound up in the hospital on her birthday with a kidney stone.  The ER doctor told her that it was small so she'd have to pass it.  She was in so much pain.  She was so upset that she went home and started researching passing stones on the internet.  Chanca Piedra had just been released on the NutraMedix website so she placed her order and it arrived the next day.  She started feeling better IMMEDIATELY and was totally out of pain within 3 hours."-T.M.

Dosage Information

30 drops twice daily at least 30 minutes before meals (start with 2-4 drops in 4 oz. of water adding 2-4 drops with each dose as tolerated, taking remedies for Herxheimer reactions if needed).

Protocols

Safety Information

Product Label

Chanca Piedra: Antimicrobial Antimicrobial Antioxidant

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%.

Download PDFRead more
Chanca Piedra: Antimicrobial Antimicrobial Effect

Solanum nigrum and Phyllanthus niruri are common herbs which are indigeneous to India. Solanum nigrum commonly called ‘manathakkali Keerai’ in Tamil, forms an indispensable part of South Indian diet.

Download PDFRead more
Chanca Piedra: Kidney Function Phyllanthus

Phylanthus niruri has been used to treat ailments related to the urogenital organs. In this study, this herb was hypothesized to help to ameliorate kidney disease in diabetes mellitus (DM).

Download PDFRead more
Chanca Piedra: Immunomodulating immunostimulatory

Plant derived immunostimulants are a promising alternative to chemotherapeutics and also perhaps vaccines. In the present study, we examined the immunostimulating properties of aqueous leaf extract of Phyllanthus niruri, an Indian traditional medicinal herb, on neutrophil activation and antibody response of Oreochromis mossambicus (Peters).

Download PDFRead more
Chanca Piedra: Cancer Extraction

In this study the potential use of an aqueous two phase system (ATPS) for the extraction of two lignans from Phyllanthus Niruri L. was evaluated and optimized using response surface methodology (RSM). Their anti-cancer potential against human lung cancer cell line A549, hepatic cancer cell line SMMC-7721, gastric cancer cell line MGC-803 were also evaluated respectively.

Download PDFRead more
Chanca Piedra: Various properties (potential)

Phyllanthus niruri is a traditional shrub of the genus Phyllanthaceae with long-standing Ayurvedic, Chinese and Malay ethnomedical records. Preliminary studies from cell and animal model have provided valuable scientific evidence for its use.

Download PDFRead more
Chanca Piedra: Cancer (T47d)

Breast cancer is one of the most commonly diagnosed cancers and the leading causes of cancer death in women worldwide. Endophytic fungi becomes anticancer metabolite sources which alternatively in plants.

Download PDFRead more
Chanca Piedra: Antimicrobial (pongamia)

The antibacterial and antifungal activities of chloroform, ethanol, acetone and aqueous extracts of Pongamia glabra and Phyllanthus niruri leaves were screened. In antibacterial activity assay followed by standard disc diffusion method against Escherichia coli, Staphylococcus aureus, Micrococcus luteus and Enterobacter aerogens.

Download PDFRead more
Chanca Piedra: Antifungal (saponin)

The in-vitro and in-vivo antifungal activities of saponin extracted from Phyllanthus niruri were investigated. The proximate composition of the plant determined using the methods of the Association of Official Analytical Chemists showed that the moisture, dry matter, crude protein, crude fibre, total ash and fat were available in 1.34 g, 98.66 g, 12.33 g 18.45 g, 7.36 g and 2.54 g/100 g respectively.

Download PDFRead more
Chanca Piedra: Various Properties (potential)

Introduction: Phyllanthus niruri is a traditional shrub of the genus Phyllan-thaceae with long-standing Ayurvedic, Chinese and Malay ethnomedical records. Preliminary studies from cell and animal model have provided valuable scientific evidence for its use.

Download PDFRead more
Chanca Piedra: Antioxidant (three plants)

Characterization and quantification of secondary metabolites and their bioactivity studies are essential to increase the knowledge on plants with traditional medicinal uses towards efficient and safe utilization.

Download PDFRead more
Chanca Piedra: Anti-inflammatory (leaves)

Background: The medicinal plants signify a massive basin of potential phytoconstituents that could be valuable as a substitute to allopathic drugs or considered as an analogue in drug development. Phyllanthus niruri L. (Euphorbiaceae) is generally used in traditional medicine to treat ulcer and inflammation. In this project we investigated the methanolic extract of leaves of Phyllanthus niruri for anti-inflammatory and anti-ulcer activity.

Download PDFRead more
Chanca Piedra: Aqueous Extract of Phyllanthus niruri Leaves...

P. niruri has been reported to possess antidiabetic and kidney protective effects. In the present study, the phytochemical constituents and in vitro antioxidant activity of P. niruri leaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney.

Download PDFRead more
Chanca Piedra: Antiplasmodial (cytotoxicity)

In endemic areas where malaria is prevalent, medicinal plants are often used to treat malaria. This study was conducted to evaluate the in vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of meniran (Phyllanthus niruri L.) herb traditionally used to treat malaria in Indonesia.

Download PDFRead more
Chanca Piedra: Various properties (review)

This review discusses the medicinal plant Phyllanthus niruri Linn. (Euphorbiaceae), its wide variety of phytochemicals and their pharmacological properties. The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri.

Download PDFRead more
Chanca Piedra: Various properties (activation)

Herbal-derived medications are an important resource in eliminating serious diseases in developing countries. About 60–85% of the world’s inhabitants depend on traditional medicine for the treatment of common diseases.

Download PDFRead more
Chanca Piedra: Immunomodulating

Phyllanthus niruri (Euphorbiaceae) is reputed globally for its versatile application in traditional medicine of many Asian, African, and South American countries. In many preclinical and clinical studies, extracts of P. niruri have been associated with many beneficial pharmacological and therapeutic effects.

Download PDFRead more
Chanca Piedra: IBS

Postinfectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of IBS begin after an episode of acute gastroenteritis. Published studies have reported incidence of PI-IBS that ranged between 5% and 32%. Its high prevalence and the considerable effects on quality of life make PI-IBS a disease with high social cost.

Download PDFRead more
Chanca Piedra: Hepatoprotective

Liver diseases are commonly caused by viral infections, drug overdose, reactions to prescribed drugs and medications, prolonged or excessive exposure to environmental toxins, and long term effects of alcohol consumption.

Download PDFRead more
Chanca Piedra: Antiplasmodial (geographical)

Extracts of Phyllanthus niruri L., collected from three different areas in the Congo (Kisantu, Kimwenza and University of Kinshasa), used for malaria treatment were tested in vitro in order to evaluate their antiplasmodial properties.

Download PDFRead more
Chanca Piedra: Antiplasmodial (fresh)

It is well known that plant species synthesize and accumulate various secondary metabolites belonging to different phytochemical groups. In intact plants, the formation of these metabolites is regulated in a coordinated fashion. Differentiation of plant cells or tissues during development is implied in this process.

Download PDFRead more
Chanca Piedra: Antiplasmodial (Chloroform)

The increasing burden of malaria has contributed significantly to poverty, decreased productivity and slow economic growth in malaria endemic regions. In 2010 alone, an estimated 655 000 cases of malaria-associated deaths were recorded, especially in very young African children.

Download PDFRead more
Chanca Piedra: Antimicrobial

The potential of water extracts of the Amazon medicinal plant Chancapiedra (Phyllanthus niruri L.) from Ecuador and Peru for antimicrobial activity against Helicobacter pylori and different strains of lactic acid bacteria such as Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum was investigated.

Download PDFRead more
Chanca Piedra: Antioxidant (paracetamol)

Reactive oxygen species (ROS) are generated spontaneously in cells during metabolism and are implicated in the aeitology of different degenerative diseases, such as heart diseases, stroke, rheumatoid arthritis, diabetes and cancer.

Download PDFRead more
Chanca Piedra: Antioxidant (nimesulide)

Nimesulide (NIM), an atypical non-steroidal anti-inflammatory drug (NSAID) is also used as analgesic. In the present study, we evaluated its effect on the prooxidant-antioxidant system of liver and the hepatoprotective potential of aqueous extract of the herb Phyllanthus niruri (PN) on NIM-induced oxidative stress in vivo using a murine model, by determining the activities of hepatic anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT), levels of reduced glutathione (GSH) and lipid peroxidation (expressed as malonaldialdehyde, MDA).

Download PDFRead more
Chanca Piedra: Antioxidant (liver)

Herbal products have been used since the dawn of civilization on the earth to maintain human health and to get the remedies from various diseases by the vast majority of the world’s population. Among these herbs, Phyllanthus niruri, has been widely used for the treatment of jaundice and other hepatic disorders.

Download PDFRead more
Chanca Piedra: Antioxidant (Herbal)

Present study was conducted to evaluate the role of a protein fraction (PI, protein isolate) of the herb, Phyllanthus niruri (P. niruri) against nimesulide-induced oxidative stress in vivo using a murine model.

Download PDFRead more
Chanca Piedra: Antioxidant (hepatoprotective)

Free radicals, from both endogenous and exogenous sources, are implicated in the etiology of several degenerative diseases, such as coronary artery diseases, stroke, rheumatoid arthritis, diabetes and cancer.

Download PDFRead more
Chanca Piedra: Antioxidant (Acetaminophen)

The aim of this study was to investigate the hepatoprotective action of the protein fraction of Phyllanthus niruri against acetaminophen (APAP) hepatotoxicity. The partially purified protein fraction of P. niruri was injected intraperitoneally in mice either prior to (preventive) or after the induction of toxicity (curative).

Download PDFRead more
Chanca Piedra: Antihyperuricemic

Phyllanthus niruri Linn. (Euphorbiaceae) is used as folk medicine in South America to treat excess uric acid. Our initial study showed that the methanol extract of Phyllanthus niruri and its lignans were able to reverse the plasma uric acid of hyperuricemic animals.

Download PDFRead more
Chanca Piedra: Antibacterial

The use of plants to heal or combat illness is as old as mankind. Since age long, plants have remained the basis for the development of modem drugs for human health. Medicinal plants are considerably useful and economically essential.

Download PDFRead more
Chanca Piedra: Tumors

Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemopreventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as chemopreventive agents.

Download PDFRead more
Chanca Piedra: Malaria (morinda)

The ethanolic, dichloromethane and lyophilized aqueous extracts of Cassia occidentalis root bark, Morinda morindoides leaves and whole plants of Phyllanthus niruri were evaluated for their antimalarial activity in vivo, in 4-day, suppressive assays against Plasmodium berghei ANKA in mice.

Download PDFRead more
Chanca Piedra: Urolithiasis

In spite of considerable efforts to identify effective treatments for urolithiasis, this is a goal yet to be achieved. This review summarizes experimental and clinical data evaluating the effect of the plant Phyllanthus niruri, a plant with worldwide distribution, as a potential agent to prevent and/or to treat urolithiasis.

Download PDFRead more
Chanca Piedra: Liver cirrhosis

A preclinical study was performed to determine if the extract from Phyllanthus niruri (PN) plays a protective role against liver cirrhosis induced by thioacetamide (TAA) in rats. Initially, acute toxicity was tested and the results showed that the extract was benign when applied to healthy rats.

Download PDFRead more
Chanca Piedra: HIV

Phyllanthus niruri Linn has been used in Ayurvedic medicine for over 2,000 years and has been used in wide number of traditional ailments such as jaundice, gonorrhea, frequent menstruation, and diabetes and topically as a poultice for skin ulcers, sores, swelling, and itchness.

Download PDFRead more
Chanca Piedra: Hepatitis B

One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis.

Download PDFRead more
Chanca Piedra: Hepatitis B (lignan)

Nirtetralin B, a new lignan first reported by our team, is isolated from Phyllanthus niruri L. This plant has long been used in folk medicine for liver protection and antihepatitis B in many Asian countries.

Download PDFRead more
Chanca Piedra: Diabetes (metabolic)

Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes.

Download PDFRead more
Chanca Piedra: Diabetes (comparative)

The antidiabetic, hypolipidemic, and antioxidant properties of Phyllanthus niruri (L) (Euphorbiaceae) were compared in normal, insulin-dependent diabetes mellitus (IDDM), and non–insulin-dependent diabetes mellitus (NIDDM) animals through evaluating the effects on carbohydrate and lipid metabolism and antioxidant activities.

Download PDFRead more
Chanca Piedra: Diabetes (alloxan)

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to defective insulin action, insulin secretion or both.

Download PDFRead more
Chanca Piedra: Diabetes (aerial)

The effects of methanol extract of aerial parts of Phyllanthus niruri L. (Euphorbiaceae), an antidiabetic herb, on glucose absorption and storage in diabetes were studied to elucidate the mechanisms of blood glucose lowering and glycemic control in diabetes.

Download PDFRead more
Chanca Piedra: Dengue Virus

Mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern.

Download PDFRead more
Chanca Piedra: Antihyperuricemic

Phyllanthus niruri Linn. (Euphorbiaceae) is used as folk medicine in South America to treat excess uric acid. Our initial study showed that the methanol extract of Phyllanthus niruri and its lignans were able to reverse the plasma uric acid of hyperuricemic animals.

Download PDFRead more