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CHANCA PIEDRA

STONE BREAKER

TO RESOLVE:

  • KIDNEY STONES/GALLSTONES
  • OBSESSIVE COMPULSIVE DISORDER (OCD)
  • INFECTIONS FROM SOME PARASITES,
  • BACTERIA AND VIRUSES

General Description

Chanca Piedra –Stone Breaker is an extract produced from the leaves and stems of the Chanca Piedra (Phyllanthus niruri) plant that is found in South America.  Chanca Piedra has been used for generations by the indigenous population of South America in eliminating gallstones and kidney stones, reducing pain and spasms associated with these stones and treating malaria, colds, flu and certain other infections. Anecdotal reports in humans suggest Chanca Piedra also has anti-Babesia and anti-OCD properties.

Some Reported Medicinal Properties

ANTIVIRAL

ANTIFUNGAL

ANTIBACTERIAL

ANTISPASMODIC

ANTIMUTAGENIC

DIURETIC

HYPOGLYCEMIC

ANTILITHIC

ANALGESIC

ANTIMALARIAL

HEPATOPROTECTIVE

Reasearch On Nutramedix Product

Medical Conditions [peer-reviewed journals]

Dengue Virus

Suresh, U., Murugan, K., Benelli, G., Nicoletti, M., Barnard, D. R., Panneerselvam, C., ... & Chandramohan, B. (2015). Tackling the growing threat of dengue: Phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector Aedes aegypti (Diptera: Culicidae). Parasitology Research, 114(4), 1551-1562. Full Article

Diabetes

Mediani, A., Abas, F., Maulidiani, M., Khatib, A., Tan, C. P., Ismail, I. S., ... & Lajis, N. H. (2016). Metabolic and biochemical changes in streptozotocin induced obese-diabetic rats treated with Phyllanthus niruri extract. Journal of Pharmaceutical and Biomedical Analysis, 128, 302-312. Full Article

Okoli, C. O., Obidike, I. C., Ezike, A. C., Akah, P. A., & Salawu, O. A. (2011). Studies on the possible mechanisms of antidiabetic activity of extract of aerial parts of Phyllanthus niruri. Pharmaceutical Biology, 49(3), 248-255. Full Article

Okoli, C. O., Ibiam, A. F., Ezike, A. C., Akah, P. A., & Okoye, T. C. (2010). Evaluation of antidiabetic potentials of Phyllanthus niruri in alloxan diabetic rats. African Journal of Biotechnology, 9(2). Full Article

Bavarva, J. H., & Narasimhacharya, A. V. R. L. (2007). Comparative Antidiabetic, Hypolipidemic, and Antioxidant Properties of Phyllanthus niruri. in Normal and Diabetic Rats. Pharmaceutical Biology, 45(7), 569-574. Full Article

Hepatitis B

Liu, S., Wei, W., Li, Y., Lin, X., Shi, K., Cao, X., & Zhou, M. (2014). In vitro and in vivo anti-hepatitis B virus activities of the lignan nirtetralin B isolated from Phyllanthus niruri L. Journal of Ethnopharmacology, 157, 62-68. Full Article

Wei, W., Li, X., Wang, K., Zheng, Z., & Zhou, M. (2012). Lignans with Anti‐Hepatitis B Virus Activities from Phyllanthus niruri L. Phytotherapy Research, 26(7), 964-968. Full Article

HIV

Naik, A. D., & Juvekar, A. R. (2003). Effects of alkaloidal extract of Phyllanthus niruri on HIV replication. Indian Journal of Medical Sciences, 57(9), 387-393. Full Article

Liver Cirrhosis

Amin, Z. A., Bilgen, M., Alshawsh, M. A., Ali, H. M., Hadi, A. H. A., & Abdulla, M. A. (2012). Protective role of Phyllanthus niruri extract against thioacetamide-induced liver cirrhosis in rat model. Evidence-Based Complementary and Alternative Medicine, 2012. Full Article

Urolithiasis (Kidney Stones)

Boim, M. A., Heilberg, I. P., & Schor, N. (2010). Phyllanthus niruri as a promising alternative treatment for nephrolithiasis. International Braz J Urol, 36(6), 657-664. Full Article

Malaria

Tona, L., Mesia, K., Ngimbi, N. P., Chrimwami, B., Okond'Ahoka, Cimanga, K., ... & Pieters, L. (2001). In-vivo antimalarial activity of Cassia occidentalism Morinda morindoides and Phyllanthus niruri. Annals of Tropical Medicine & Parasitology, 95(1), 47-57. Full Article

Tumors

Sharma, P., Parmar, J., Verma, P., Sharma, P., & Goyal, P. K. (2009). Anti-tumor activity of Phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asian Pac J Cancer Prev, 10(6), 1089-1094. Full Article

Medicinal Properties [peer-reviewed journals]

Antibacterial

Ekwenye, U. N., & Njoku, N. U. (2006). Antibacterial effect of Phyllanthus niruri (Chanca Piedra) on three enteropathogens in Man. International Journal of Molecular Medicine and Advance Sciences, 2(2), 184-189. Full Article

Antihyperuricemic

Murugaiyah, V., & Chan, K. L. (2009). Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents. Journal of Ethnopharmacology, 124(2), 233-239. Full Article

Antioxidant

Sabir, S. M., & Rocha, J. B. T. (2008). Water-extractable phytochemicals from Phyllanthus niruri exhibit distinct in vitro antioxidant and in vivo hepatoprotective activity against paracetamol-induced liver damage in mice. Food Chemistry, 111(4), 845-851. Full Article

Bhattacharjee, R., & Sil, P. C. (2007). Protein isolate from the herb, Phyllanthus niruri L.(Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food and Chemical Toxicology, 45(5), 817-826. Full Article

Chatterjee, M., Sarkar, K., & Sil, P. C. (2006). Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress. Pathophysiology, 13(2), 95-102. Full Article

Chatterjee, M., & Sil, P. C. (2006). Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo. Indian Journal of Biochemistry & Biophysics, 43, 299-305. Full Article

Bhattacharjee, R., & Sil, P. C. (2006). The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(7), 595-601. Full Article

Harish, R., & Shivanandappa, T. (2006). Antioxidant activity and hepatoprotective potential of Phyllanthus niruri. Food Chemistry, 95(2), 180-185. Full Article

Antimicrobial

Ranilla, L. G., Apostolidis, E., & Shetty, K. (2012). Antimicrobial activity of an Amazon medicinal plant (Chancapiedra)(Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria. Phytotherapy Research, 26(6), 791-799. Full Article

Anti-inflammatory

Ifeoma, O., Samuel, O., Itohan, A. M., & Adeola, S. O. (2013). Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pacific Journal of Tropical Medicine, 6(3), 169-175. Full Article

Antiplasmodial

Ifeoma, O., Samuel, O., Itohan, A. M., & Adeola, S. O. (2013). Isolation, fractionation and evaluation of the antiplasmodial properties of Phyllanthus niruri resident in its chloroform fraction. Asian Pacific Journal of Tropical Medicine, 6(3), 169-175. Full Article

Soh, P. N., Banzouzi, J. T., Mangombo, H., Lusakibanza, M., Bulubulu, F. O., Tona, L., ... & Luyindula, S. N. (2009). Antiplasmodial activity of various parts of Phyllanthus niruri according to its geographical distribution. African journal of Pharmacy and Pharmacology, 3(12), 598-601. Full Article

Mustofa, S. E., & Wahyuono, S. (2007). In vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of Phyllanthus niruri L. herbs traditionally used to treat malaria in Indonesia. Southeast Asian J Trop Med Public Health, 38(4), 609-615. Full Article

Cimanga, R. K., Tona, L., Luyindula, N., Mesia, K., Lusakibanza, M., Musuamba, C. T., ... & Totté, J. (2004). In vitro antiplasmodial activity of callus culture extracts and fractions from fresh apical stems of Phyllanthus niruri L.(Euphorbiaceae): part 2. Journal of Ethnopharmacology, 95(2-3), 399-404. Full Article

Hepatoprotective

Ooi, K. L., Loh, S. I., Sattar, M. A., Muhammad, T. S. T., & Sulaiman, S. F. (2015). Cytotoxic, caspase-3 induction and in vivo hepatoprotective effects of phyllanthin, a major constituent of Phyllanthus niruri. Journal of Functional Foods, 14, 236-243. Full Article

IBS

Giribabu, N., Rao, P. V., Kumar, K. P., Muniandy, S., Swapna Rekha, S., & Salleh, N. (2014). Aqueous extract of Phyllanthus niruri leaves displays in vitro antioxidant activity and prevents the elevation of oxidative stress in the kidney of streptozotocin-induced diabetic male rats. Evidence-Based Complementary and Alternative Medicine, 2014. Full Article

Immunomodulating

Nworu, C. S., Akah, P. A., Okoye, F. B. C., Proksch, P., & Esimone, C. O. (2010). The effects of Phyllanthus niruri aqueous extract on the activation of murine lymphocytes and bone marrow-derived macrophages. Immunological investigations, 39(3), 245-267. Full Article

Various properties

Amin, Z. A., Abdulla, M. A., Ali, H. M., Alshawsh, M. A., & Qadir, S. W. (2012). Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri. Journal of the Science of Food and Agriculture, 92(9), 1874-1877. Full Article

Bagalkotkar, G., Sagineedu, S. R., Saad, M. S., & Stanslas, J. (2006). Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review. Journal of Pharmacy and Pharmacology, 58(12), 1559-1570. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Patient Reports

"My daughter was turning 37 and wound up in the hospital on her birthday with a kidney stone.  The ER doctor told her that it was small so she'd have to pass it.  She was in so much pain.  She was so upset that she went home and started researching passing stones on the internet.  Chanca Piedra had just been released on the NutraMedix website so she placed her order and it arrived the next day.  She started feeling better IMMEDIATELY and was totally out of pain within 3 hours."-T.M.

Dosage Information

30 drops twice daily at least 30 minutes before meals (start with 2-4 drops in 4 oz. of water adding 2-4 drops with each dose as tolerated, taking remedies for Herxheimer reactions if needed).

Protocols

Safety Information

Product Label

Chanca Piedra: Aqueous Extract of Phyllanthus niruri Leaves...

P. niruri has been reported to possess antidiabetic and kidney protective effects. In the present study, the phytochemical constituents and in vitro antioxidant activity of P. niruri leaf aqueous extract were investigated together with its effect on oxidative stress and antioxidant enzymes levels in diabetic rat kidney.

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Chanca Piedra: Antiplasmodial (cytotoxicity)

In endemic areas where malaria is prevalent, medicinal plants are often used to treat malaria. This study was conducted to evaluate the in vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of meniran (Phyllanthus niruri L.) herb traditionally used to treat malaria in Indonesia.

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Chanca Piedra: Various properties (review)

This review discusses the medicinal plant Phyllanthus niruri Linn. (Euphorbiaceae), its wide variety of phytochemicals and their pharmacological properties. The active phytochemicals, flavonoids, alkaloids, terpenoids, lignans, polyphenols, tannins, coumarins and saponins, have been identified from various parts of P. niruri.

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Chanca Piedra: Various properties (activation)

Herbal-derived medications are an important resource in eliminating serious diseases in developing countries. About 60–85% of the world’s inhabitants depend on traditional medicine for the treatment of common diseases.

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Chanca Piedra: Immunomodulating

Phyllanthus niruri (Euphorbiaceae) is reputed globally for its versatile application in traditional medicine of many Asian, African, and South American countries. In many preclinical and clinical studies, extracts of P. niruri have been associated with many beneficial pharmacological and therapeutic effects.

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Chanca Piedra: IBS

Postinfectious irritable bowel syndrome (PI-IBS) is a common disorder wherein symptoms of IBS begin after an episode of acute gastroenteritis. Published studies have reported incidence of PI-IBS that ranged between 5% and 32%. Its high prevalence and the considerable effects on quality of life make PI-IBS a disease with high social cost.

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Chanca Piedra: Hepatoprotective

Liver diseases are commonly caused by viral infections, drug overdose, reactions to prescribed drugs and medications, prolonged or excessive exposure to environmental toxins, and long term effects of alcohol consumption.

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Chanca Piedra: Antiplasmodial (geographical)

Extracts of Phyllanthus niruri L., collected from three different areas in the Congo (Kisantu, Kimwenza and University of Kinshasa), used for malaria treatment were tested in vitro in order to evaluate their antiplasmodial properties.

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Chanca Piedra: Antiplasmodial (fresh)

It is well known that plant species synthesize and accumulate various secondary metabolites belonging to different phytochemical groups. In intact plants, the formation of these metabolites is regulated in a coordinated fashion. Differentiation of plant cells or tissues during development is implied in this process.

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Chanca Piedra: Antiplasmodial (Chloroform)

The increasing burden of malaria has contributed significantly to poverty, decreased productivity and slow economic growth in malaria endemic regions. In 2010 alone, an estimated 655 000 cases of malaria-associated deaths were recorded, especially in very young African children.

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Chanca Piedra: Antimicrobial

The potential of water extracts of the Amazon medicinal plant Chancapiedra (Phyllanthus niruri L.) from Ecuador and Peru for antimicrobial activity against Helicobacter pylori and different strains of lactic acid bacteria such as Lactobacillus acidophilus, Lactobacillus casei and Lactobacillus plantarum was investigated.

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Chanca Piedra: Antioxidant (paracetamol)

Reactive oxygen species (ROS) are generated spontaneously in cells during metabolism and are implicated in the aeitology of different degenerative diseases, such as heart diseases, stroke, rheumatoid arthritis, diabetes and cancer.

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Chanca Piedra: Antioxidant (nimesulide)

Nimesulide (NIM), an atypical non-steroidal anti-inflammatory drug (NSAID) is also used as analgesic. In the present study, we evaluated its effect on the prooxidant-antioxidant system of liver and the hepatoprotective potential of aqueous extract of the herb Phyllanthus niruri (PN) on NIM-induced oxidative stress in vivo using a murine model, by determining the activities of hepatic anti-oxidant enzymes superoxide dismutase (SOD) and catalase (CAT), levels of reduced glutathione (GSH) and lipid peroxidation (expressed as malonaldialdehyde, MDA).

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Chanca Piedra: Antioxidant (liver)

Herbal products have been used since the dawn of civilization on the earth to maintain human health and to get the remedies from various diseases by the vast majority of the world’s population. Among these herbs, Phyllanthus niruri, has been widely used for the treatment of jaundice and other hepatic disorders.

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Chanca Piedra: Antioxidant (Herbal)

Present study was conducted to evaluate the role of a protein fraction (PI, protein isolate) of the herb, Phyllanthus niruri (P. niruri) against nimesulide-induced oxidative stress in vivo using a murine model.

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Chanca Piedra: Antioxidant (hepatoprotective)

Free radicals, from both endogenous and exogenous sources, are implicated in the etiology of several degenerative diseases, such as coronary artery diseases, stroke, rheumatoid arthritis, diabetes and cancer.

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Chanca Piedra: Antioxidant (Acetaminophen)

The aim of this study was to investigate the hepatoprotective action of the protein fraction of Phyllanthus niruri against acetaminophen (APAP) hepatotoxicity. The partially purified protein fraction of P. niruri was injected intraperitoneally in mice either prior to (preventive) or after the induction of toxicity (curative).

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Chanca Piedra: Antihyperuricemic

Phyllanthus niruri Linn. (Euphorbiaceae) is used as folk medicine in South America to treat excess uric acid. Our initial study showed that the methanol extract of Phyllanthus niruri and its lignans were able to reverse the plasma uric acid of hyperuricemic animals.

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Chanca Piedra: Antibacterial

The use of plants to heal or combat illness is as old as mankind. Since age long, plants have remained the basis for the development of modem drugs for human health. Medicinal plants are considerably useful and economically essential.

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Chanca Piedra: Tumors

Chemoprevention is an important strategy to control the process of carcinogenesis. The potential of using medicinal herbs as cancer chemopreventive nutraceuticals and functional food is promising. Thus, there is a need for exploring drugs/agents which act as chemopreventive agents.

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Chanca Piedra: Malaria (morinda)

The ethanolic, dichloromethane and lyophilized aqueous extracts of Cassia occidentalis root bark, Morinda morindoides leaves and whole plants of Phyllanthus niruri were evaluated for their antimalarial activity in vivo, in 4-day, suppressive assays against Plasmodium berghei ANKA in mice.

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Chanca Piedra: Urolithiasis

In spite of considerable efforts to identify effective treatments for urolithiasis, this is a goal yet to be achieved. This review summarizes experimental and clinical data evaluating the effect of the plant Phyllanthus niruri, a plant with worldwide distribution, as a potential agent to prevent and/or to treat urolithiasis.

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Chanca Piedra: Liver cirrhosis

A preclinical study was performed to determine if the extract from Phyllanthus niruri (PN) plays a protective role against liver cirrhosis induced by thioacetamide (TAA) in rats. Initially, acute toxicity was tested and the results showed that the extract was benign when applied to healthy rats.

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Chanca Piedra: HIV

Phyllanthus niruri Linn has been used in Ayurvedic medicine for over 2,000 years and has been used in wide number of traditional ailments such as jaundice, gonorrhea, frequent menstruation, and diabetes and topically as a poultice for skin ulcers, sores, swelling, and itchness.

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Chanca Piedra: Hepatitis B

One new lignan, nirtetralin B, along with its two known stereoisomers were isolated from Phyllanthus niruri L. The structure of the new compound was determined by spectroscopy experiments and x-ray diffraction analysis.

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Chanca Piedra: Hepatitis B (lignan)

Nirtetralin B, a new lignan first reported by our team, is isolated from Phyllanthus niruri L. This plant has long been used in folk medicine for liver protection and antihepatitis B in many Asian countries.

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Chanca Piedra: Diabetes (metabolic)

Herbal medicine has been proven to be an effective therapy offering a variety of benefits, such as moderate reduction in hypoglycemia, in the treatment and prevention of obesity and diabetes.

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Chanca Piedra: Diabetes (comparative)

The antidiabetic, hypolipidemic, and antioxidant properties of Phyllanthus niruri (L) (Euphorbiaceae) were compared in normal, insulin-dependent diabetes mellitus (IDDM), and non–insulin-dependent diabetes mellitus (NIDDM) animals through evaluating the effects on carbohydrate and lipid metabolism and antioxidant activities.

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Chanca Piedra: Diabetes (alloxan)

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to defective insulin action, insulin secretion or both.

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Chanca Piedra: Diabetes (aerial)

The effects of methanol extract of aerial parts of Phyllanthus niruri L. (Euphorbiaceae), an antidiabetic herb, on glucose absorption and storage in diabetes were studied to elucidate the mechanisms of blood glucose lowering and glycemic control in diabetes.

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Chanca Piedra: Dengue Virus

Mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. Dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. Recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern.

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Chanca Piedra: Antihyperuricemic

Phyllanthus niruri Linn. (Euphorbiaceae) is used as folk medicine in South America to treat excess uric acid. Our initial study showed that the methanol extract of Phyllanthus niruri and its lignans were able to reverse the plasma uric acid of hyperuricemic animals.

Download PDFRead more