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General Description

Burbur Pinella is a combination of two extracts: Burbur, produced from Desmodium molliculum, and Pinella, produced from Pimpinella anisum; both perennial plants from South America.  The herb in Burbur has been traditionally used for its body cleansing properties. It is very effective in aiding detoxification of the liver, kidneys, lymphatic system and the ground matrix. Pinella is reported to be very effective in eliminating both man-made and biotoxins from the brain, spinal cord, and peripheral nervous system. Burbur and Pinella are both integral components of the Cowden Support Program, a Lyme disease protocol developed by Wm. Lee Cowden, MD. The combination of Burbur and Pinella is very effective when a Herxheimer-like reaction is suspected.

Some Reported Medicinal Properties














Research On NutraMedix Product

in vivo – Anti-inflammatory

Establishment of the Potential Anti-inflammatory Effect of the product known as Burbur. The study demonstrated that Burbur had a marked anti-inflammatory effect and was 60% as effective as Feldene, a non-steroidal anti-inflammatory drug also known as PIROXICAM. University of Guayaquil, Department of Chemical Sciences, Guayaquil, Ecuador (2005) Full Article


An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Burbur did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

Medical Conditions [peer-reviewed journals]


Kadan, S., Rayan, M., & Rayan, A. (2013). Anticancer activity of anise (Pimpinella anisum L.) seed extract. The Open Nutraceuticals Journal, 6(1). Full Article

Medicinal Properties [peer-reviewed journals]


Al-Bayati, F. A. (2008). Synergistic antibacterial activity between Thymus vulgaris and Pimpinella anisum essential oils and methanol extracts. Journal of Ethnopharmacology, 116(3), 403-406. Full Article

Bussmann, R. W., Sharon, D., Perez, F., Díaz, D., Ford, T., Rasheed, T., & Silva, R. (2008). Antibacterial activity of Northern-Peruvian Medicinal Plants-a low-cost laboratory approach to assess biological activity. Arnaldoa, 15(1), 127-148. Full Article

Akhtar, A., Deshmukh, A. A., Bhonsle, A. V., Kshirsagar, P. M., & Kolekar, M. A. (2008). In vitro antibacterial activity of Pimpinella anisum fruit extracts against some pathogenic bacteria. Veterinary World, 1(9), 272-274. Full Article


Lock, O., Castillo, P., Doroteo, V., & Rojas, R. (2005). Antioxidant activity in vitro of selected Peruvian medicinal plants. Acta Horticulturae, 675, 103-106. Full Article

 Gülçın, İ., Oktay, M., Kıreçcı, E., & Küfrevıoǧlu, Ö. İ. (2003). Screening of antioxidant and antimicrobial activities of anise (Pimpinella anisum L.) seed extracts. Food Chemistry, 83(3), 371-382. Full Article


Karimzadeh, F., Hosseini, M., Mangeng, D., Alavi, H., Hassanzadeh, G. R., Bayat, M., ... & Gorji, A. (2012). Anticonvulsant and neuroprotective effects of Pimpinella anisum in rat brain. BMC Complementary and Alternative Medicine, 12(1), 76. Full Article

Pourgholami, M. H., Majzoob, S., Javadi, M., Kamalinejad, M., Fanaee, G. H. R., & Sayyah, M. (1999). The fruit essential oil of Pimpinella anisum exerts anticonvulsant effects in mice. Journal of Ethnopharmacology, 66(2), 211-215. Full Article


Yazdani, D., Rezazadeh, S. H., Amin, G. H., Abidin, Z., Shahnazi, S., & Jamalifar, H. (2009). Antifungal activity of dried extracts of anise (Pimpinella anisum L.) and star anise (Illicium verum Hook. f.) against dermatophyte and saprophyte fungi. Journal of Medicinal Plants, 1(29), 24-29. Full Article

Kosalec, I., Pepeljnjak, S., & Kuštrak, D. (2005). Antifungal activity of fluid extract and essential oil from anise fruits (Pimpinella anisum L., Apiaceae). Acta Pharmaceutica, 55(4), 377-385. Full Article

Shukla, H. S., & Tripathi, S. G. (1987). Antifungal substance in the essential oil of anise (Pimpinella anisum L.). Agricultural and Biological Chemistry, 51(7), 1991-1993. Full Article


Gende, L. B., Maggi, M. D., Fritz, R., Eguaras, M. J., Bailac, P. N., & Ponzi, M. I. (2009). Antimicrobial activity of Pimpinella anisum and Foeniculum vulgare essential oils against Paenibacillus larvae. Journal of Essential Oil Research, 21(1), 91-93. Full Article

Rojas, R., Bustamante, B., Bauer, J., Fernández, I., Albán, J., & Lock, O. (2003). Antimicrobial activity of selected Peruvian medicinal plants. Journal of Ethnopharmacology, 88(2-3), 199-204. Full Article


Lee, J. B., Yamagishi, C., Hayashi, K., & Hayashi, T. (2011). Antiviral and immunostimulating effects of lignin-carbohydrate-protein complexes from Pimpinella anisum. Bioscience, Biotechnology, and Biochemistry, 75(3), 459-465. Full Article

Shukla, H. S., Dubey, P., & Chaturvedi, R. V. (1989). Antiviral properties of essential oils of Foeniculum vulgare and Pimpinella anisum L. Agronomie, 9(3), 277-279. Full Article


Tirapelli, C. R., de Andrade, C. R., Cassano, A. O., De Souza, F. A., Ambrosio, S. R., da Costa, F. B., & de Oliveira, A. M. (2007). Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle. Journal of Ethnopharmacology, 110(1), 23-29. Full Article

Boskabady, M. H., & Ramazani-Assari, M. (2001). Relaxant effect of Pimpinella anisum on isolated guinea pig tracheal chains and its possible mechanism (s). Journal of Ethnopharmacology, 74(1), 83-88. Full Article

Various Properties

Shojaii, A., & Abdollahi Fard, M. (2012). Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN Pharmaceutics, 2012. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]


Conference Presentations

Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video

Patient Reports

"I was diagnosed with Lyme Disease and began taking the Cowden Support Program.  As I detoxed, my body went into a Herxheimer reaction and it completely subsided when I began taking Burbur-Pinella!"  -A.E.

“This is very powerful and helpful for lyme disease herxheimers and brain thickness and tingling and numbness. I take 8 drops per 8 oz water, as much as i need. I'm so glad I found this.” –M.Y

“This product was recommended by my Integrated Medicine doctor and is definitely helping to calm my nerves and nervous ticks that have come with Lyme and co-infections. It seems to help my overall mood also. I'm very thankful for this product!” –R.F

"Six years ago, I kept having back pain; was diagnosed with beginning stages of kidney failure.  My naturopath put me on Burbur-Pinella a few months ago and the pain and all effects of kidney failure are gone.  Burbur-Pinella is a miraculous product."  -N.A.

"A friend recommended that I try Burbur Pinella since bronchitis had gotten a hold of me BIG TIME.  It eliminated my cough TOTALLY!!!"  -R.E.

Dosage Information

General Detox Aid: Take 20 drops in 4 oz. of water 1-2 times daily.

Mild Toxicity, Brain Fog: Take 10 drops 3-4 times daily.

May be taken several times per day as needed.

Moderate to Severe Toxicity and Herxheimer Reaction (healing crisis): Take 20 drops every 15 minutes in 2 oz. of water until symptoms are resolved.

Can also put 4 droppers full (approximately 120 drops) in at least 16 oz. of water and sip over a 2-hour period, repeating until symptoms are resolved.


Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Burbur did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article

Product Label

Pinella: Antioxidant (ripening)

Chemical composition and antioxidant activity of four aniseed populations (Egyptian, Serbian, Tunisian and Turkish) were investigated during three developmental stages. The highest oil yield was achieved at full maturity in all aniseed accessions ranged from 11.93% (Serbia) to 13.80% (Tunisia). Fatty acid profile of aniseed oil was characterized by high proportions of palmitic (4.90–57.18%) and petroselinic (10.48–46.60%) acids which had an antagonist evolution during maturation.

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Pinella: Antifungal (cuminum)

Investigations were conducted to evaluate the antifungal activity of anise and cumin essential oils on mycelia growth of 90 isolates of fungi. The agar-well diffusion method was used to evaluate fungal growth inhibition at a concentration of 100%.

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Burbur-Pinella: Anticancer Activity of Anise (Pimpinella anisum L.) Seed Extract

Cancer incidence is much lower in India than in western countries. The reason is not fully understood, but the high spice consumption could be one of the contributing factors. Anise is one of the plants grows in India and people from our region believe that anise seeds are helpful in cancer prevention and treatment. In this study, anticancer activity of ethanol extract of anise (Pimpinella anisum L.) seed was investigated.

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Pinella: Relaxant (smooth)

Because Pimpinella anisum is highly used in the folk medicine, a study of its physiological properties was deemed necessary and informative. At present, the mechanisms involved in the relaxant action induced by the extract of Pimpinella anisum are poorly understood. This work aimed to investigate the possible mechanism(s) underlying the relaxant action of the hidroalcoholic extract of Pimpinella anisum on rat anococcygeus smooth muscle.

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Pinella: Antimicrobial

The essential oil obtained by hydrodistillation from the fruits of Pimpinella anisum L. (green anise) and Foeniculum vulgare Miller (fennel) were analyzed by GC and GC/MS and physicochemical properties.

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Pinella: Relaxant (guinea)

In the present study the relaxant effects of essential oil, aqueous and ethanol extracts of this plant in comparison with both saline and theophylline were studied by a more standard method. In addition the anticholinergic effect of essential oil of P. anisum in comparison with atropine was also studied.

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Pinella: Antioxidant (screening)

In this study, antioxidant and antimicrobial activities of water and ethanol extracts of anise (Pimpinella anisum L.) seed (PAS) were investigated. The antioxidant properties of both extracts of PAS were evaluated using different antioxidant tests, including reducing power, free radical scavenging, superoxide anion radical scavenging, hydrogen peroxide scavenging, and metal chelating activities.

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Pinella: Antifungal (fluid)

Antifungal activities of fluid extract and essential oil obtained from anise fruits Pimpinella anisum L. (Apiaceae) were tested in vitro on clinical isolates of seven species of yeasts and four species of dermatophytes.

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Pinella: Antifungal (Dried)

Medicinal plants synthesize a vast array of secondary metabolites that are important for human life. For medicinal purpose, antimicrobial activity of substances derived from plant extracts has been recognized for many years. Pimpinella anisum L. (Apiaceae) and Illicium verum Hook. f. (Illiciaceae) plant species, have been used for treatment of infectious diseases in Iranian traditional medicine.

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Pinella: Antifungal (Anise)

Previously, we reported the antifungal properties of some essential oils of angiosperms.

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Pinella: Anticonvulsant

This study investigates anticonvulsant effects of an essential oil of the fruits of Pimpinella anisum (Umbelliferae), a folkloric remedy in the Iranian traditional medicine, against seizures induced by pentylenetetrazole (PTZ) or maximal electroshock (MES) in male mice.

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Pinella: Antibacterial

The antibacterial activities of the aqueous, 50% (v/v) methanol,acetone and petroleum ether extracts of Pimpinella anisum (L) fruits were studied.

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Burbur (EC): Toxicity Test 1

OBJECTIVES: To study adverse side effects produced by the administration of Burbur Detox on body weight and different body systems.

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Burbur (EC): Anti-Inflammatory Study (English Translated)

The auricular edema is achieved by applying 12-0- Tetradecanoil Forbol-13 Acetate (TPA), one of the components responsible for the irritating action of croton oil, into the auditory pavilion of the mouse.

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Burbur: Antioxidant

The purpose of this study is to evaluate the in vital antioxidant activity of 40 plants used in Peruvian traditional medicine for the treatment of several infectious and inflammatory disorders. Plants that have been used extensively for the treatment of inflammatory or infectious diseases may contain radical scavengers compounds that could be used as natural antioxidants.

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Burbur: Antimicrobial

In Peru, like in other developing countries, medicinal plants still represent the main therapeutic tool in traditional medicine. The Peruvian flora offers great possibilities for the discovery of new compounds with antimicrobial activity. It is estimated that 17,144 flowering plant species occur in Peru of which 5354 (31.3%) are endemic.

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Burbur: Antibacterial

Peru is a country rich in biodiversity. For millennia native traditional healers have used the rich flora to cure ailments. The same plants are still being used today. Traditional medicine continues to be very popular since a large part of the population has either no access to, or no resources from Western medicine.

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Burbur: Antibacterial Activity

Bacterial infections and inflammation are among the ailments treated by traditional healers. The World Health Organization has expressed high interest in traditional medicine, and it is important to demonstrate scientifically that remedies employed in folk medicine are indeed therapeutically active.

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Burbur Detox: Acute Oral Toxicity

As discussed in numerous international works, the study of acute toxicity is indispensable, and guarantees (within the margin of error associated with the technique) that the potential for toxicity from the compounds that will be ingested or that may enter into the system accidentally will be learned.

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Burbur: Anti-Inflammatory Effect

The auricular edema is achieved by applying 12-0- Tetradecanoil Forbol-13 Acetate (TPA), one of the components responsible for the irritating action of croton oil, into the auditory pavilion of the mouse. The inflammatory reaction consists of erythema, edema and infiltration by polymorphonuclear leukocytes. As such, eicosanoid -type mediators are freed, inducing degranulation of the mast cell.

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