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TAKUNA

MICROBIAL DEFENSE

FOR FIGHTING:

  • COLDS
  • FLU
  • VIRAL HEPATITIS
  • SHINGLES
  • CYTOMEGALOVIRUS
  • EPSTEIN-BARR VIRUS
  • ACUTE AND CHRONIC VIRAL ENCEPHALITIS AND MENINGITIS
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General Description

Takuna is an extract produced from the bark of Cecropia strigosa, a tree that is found throughout South America. It has recently been found to have very powerful antiviral properties as well as some other general antimicrobial properties. Practitioners using the product have found that Takuna given every hour usually resolves influenzas in just a few hours. In some cases, the symptoms are resolved in as little as one hour. Practitioners also report that Takuna is effective against some bacterial infections and some fungal infections.

Some Reported Medicinal Properties

ANTI-AMENORRHEAL

ANTI-ASTHMATIC

ANTIBACTERIAL

ANTI-DIABETIC

ANTI-FEVER

ANTI-FREE RADICALS

ANTIFUNGAL

ANTI-HYPERPLASIA

ANTI-INFLAMMATORY

ANTI-MUCOSAL

ANTIOXIDANT

ANTI-PAIN

ANTI-PARKINSONISM

ANTI-SPASMODIC

ANTIVIRAL

DECONGESTANT

HYPOTENSIVE

PURGATIVE

Research On NutraMedix Product

In vitro – Lyme Disease

Priyanka A.S. Theophilus M.S., Eva Sapi Ph.D. (2013). In Vitro Effect of Peruvian Antimicrobial Agents on Borrelia burgdorferi Full Article

in vivo – Anti-inflammatory

At the University of Guayaquil, Ecuador, Takuna produced an anti-inflammatory effect 73% as strong as Feldeneas an anti-inflammatory. Full Article

in vivo acute oral toxicity tests

An Acute Oral toxicity study was conducted by the Department of Chemical Sciences at the University of Guayaquil, Ecuador.  The general conclusion was that Takuna did not produce toxic effects when used in accordance to the guidelines described in OECD TG 423, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article 

Medical Conditions [peer-reviewed journals]

Medicinal Properties [peer-reviewed journals]

ADJUNCTIVE TO CHEMOTHERAPY

Allen,L., Buckner, A., Buckner, C. A., Cano, P., & Lafrenie, R. M. (2017). Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae) sensitizes THP-1 cells to radiation-induced cell deathPharmacognosy Research,9(3), 221. Full Article

Farias,I., do Carmo Araújo, M., Zimmermann, E. S., Dalmora, S. L., Benedetti, A. L.,Alvarez-Silva, M., ... & Schetinger, M. R. C. (2011). Uncaria tomentosa stimulates the proliferation of myeloid progenitor cellsJournal of Ethnopharmacology, 137(1), 856-863. Full Article

Farias,I. L. G., Araújo, M. C. S., Farias, J. G., Rossato, L. V., Elsenbach, L. I.,Dalmora, S. L., ... & Schetinger, M. R. C.(2012). Uncariatomentosa for reducing side effects caused by chemotherapy in CRC patients: clinical trialEvidence-BasedComplementary and Alternative Medicine, 2012. Full Article

ANTIBACTERIAL

Nowakowska,J., Bany, J., Zdanowska, D., Czubaj, A., Kuraś, M., & Skopińska-Różewska, E.(2009). Experimental Immunology: The effect of the bark water extract Uncaria tomentosa on the Pseudomonas aeruginosa infection in mice. Central European Journal of Immunology, 34(3), 162-165. Full Article

Rodrigues, R. A., de Araujo, A. V., daCunha, R. M., & Carvalho, C. M. (2018). Antibacterial activity of endophytic fungi from the medicinal plant Uncfaria tomentosa (Willd.) DC. Journal of Medicinal Plants Research, 12(15), 179-185. Full Article

ANTIFUNGAL

Moraes,R. C., Carvalho, A. R., Lana, A. J. D., Kaiser, S., Pippi, B., Fuentefria, A.M., & Ortega, G. G. (2017). In vitro synergism of a water insoluble fraction of Uncaria tomentosa combined with fluconazole and terbinafine against resistant non-Candida albicans isolates. Pharmaceutical biology, 55(1), 406-415. Full Article

Moraes,R. C., Dalla Lana, A. J., Kaiser, S., Carvalho, A. R., de Oliveira, L. F. S., Fuentefria, A. M., & Ortega, G. G. (2015). Antifungal activity of Uncaria tomentosa (Willd.) DC against resistant non-albicans Candida isolatesIndustrial Crops and Products,69, 7-14. Full Article

ANTI-INFLAMMATORY

Montserrat-dela Paz, S., Fernandez-Arche, A., de la Puerta, R., Quilez, A. M., Muriana, F.J., Garcia-Gimenez, M. D., & Bermudez, B. (2016). Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine, 23(2), 141-148. Full Article

Rojas-Duran,R., González-Aspajo, G., Ruiz-Martel, C., Bourdy, G., Doroteo-Ortega, V. H.,Alban-Castillo, J., ... & Deharo, E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143(3),801-804. Full Article

Gonçalves,C., Dinis, T., & Batista, M. T. (2005). Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry, 66(1), 89-98. Full Article

Allen-Hall,L., Cano, P., Arnason, J. T., Rojas, R., Lock, O., & Lafrenie, R. M.(2007). Treatment of THP-1 cells with Uncaria tomentosa extractsdifferentially regulates the expression if IL-1β and TNF-αJournalof ethnopharmacology109(2), 312-317. Full Article

Aguilar, J. L., Rojas, P.,Marcelo, A., Plaza, A., Bauer, R., Reininger, E., ... & Merfort, I. (2002). Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae). Journal of Ethnopharmacology81(2), 271-276. Full Article

Sandoval, M., Okuhama, N. N.,Zhang, X. J., Condezo, L. A., Lao, J., Angeles, F. M., ... & Miller, M. J.S. (2002). Anti-inflammatory and antioxidant activities of cat's claw(Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid contentPhytomedicine9(4),325-337. Full Article

Azevedo,B. C., Morel, L. J. F., Carmona, F., Cunha, T. M., Contini, S. H. T., Delprete, P. G., ... & Borges, M. C. (2018). Aqueous extracts from Uncaria tomentosa (Willd. ex Schult.) DC. reduce bronchial hyperresponsiveness and inflammation in a murine model of asthma. Journal of ethnopharmacology, 218, 76-89. Full Article

ANTIGENOTOXIC AND ANTIMUTAGENIC

Paniagua‐Pérez, R., Madrigal‐Bujaidar, E., Molina‐Jasso, D., Reyes‐Cadena, S., Álvarez‐González, I., Sánchez‐Chapul, L., & Pérez‐Gallaga, J. (2009). Antigenotoxic, antioxidant, and lymphocyte induction effects produced by pteropodine. Basic & clinical pharmacology& toxicology, 104(3), 222-227. Full Article

ANTIMICROBIAL

Herrera,D. R., Tay, L. Y., Rezende, E. C., Kozlowski Jr, V. A., & dos Santos, E. B.(2010). In vitro antimicrobial activity of phytotherapic Uncaria tomentosa against endodontic pathogensJournal of oral science,52(3), 473-476. Full Article

Ccahuana-Vasquez, R. A., Santos, S. S. F. D., Koga-Ito, C.Y., & Jorge, A. O. C. (2007). Antimicrobial activity of Uncaria tomentosa against oralhuman pathogensBrazilian oral research, 21(1), 46-50. Full Article

ANTINEOPLASTIC

Dreifuss,A. A., Bastos-Pereira, A. L., Fabossi, I. A., dos Reis Lívero, F. A., Stolf, A.M., de Souza, C. E. A., ... & Teixeira, S. (2013). Uncaria tomentosa exerts extensiveanti-neoplastic effects against the Walker-256 tumor by modulating oxidative stress and not by alkaloid activity. PLoS One, 8(2), e54618. Full Article

Rinner,B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R.(2009). Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cellsAnticancer research, 29(11), 4519-4528. Full Article

ANTIOXIDANT

Bukowska,B., Bors, M., Gulewicz, K., & Koter-Michalak, M. (2012). Uncaria tomentosa extracts protect human erythrocyte catalase against damage induced by 2, 4-D-Na and its metabolitesFood and Chemical Toxicology, 50(6), 2123-2127. Full Article

Amaral,S., Mira, L., Nogueira, J. M. F., da Silva, A. P., & Florêncio, M. H.(2009). Plant extracts with anti-inflammatory properties—A new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationshipsBioorganic & Medicinal Chemistry, 17(5), 1876-1883. Full Article

Trejo‐Tapia, G., Sepúlveda‐Jiménez, G., Trejo‐Espino, J. L., Cerda‐García‐Rojas, C. M., De La Torre, M., Rodríguez‐Monroy, M., & Ramos‐Valdivia, A. C. (2007). Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) DCcell suspension cultures via oxidative burst. Biotechnology and Bioengineering,98(1), 230-238. Full Article

Cisneros,F. J., Jayo, M., & Niedziela, L. (2005). An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation. Journal of Ethnopharmacology, 96(3), 355-364. Full Article

Navarro-Hoyos, M., Alvarado-Corella, D.,Moreira-Gonzalez, I., Arnaez-Serrano, E., & Monagas-Juan, M. (2018). Polyphenolic Composition and Antioxidant Activity of Aqueous and Ethanolic Extracts from Uncaria tomentosa Bark andLeavesAntioxidants, 7(5), 65. Full Article

CENTRAL NERVOUS SYSTEM (CNS) SUPPORT

Kang,T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ...& Watanabe, H. (2002). Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyteEuropeanjournal of pharmacology, 444(1-2), 39-45. Full Article

CYTOPROTECTIVE

Sandoval,M., Charbonnet, R. M., Okuhama, N. N., Roberts, J., Krenova, Z., Trentacosti,A. M., & Miller, M. J. (2000). Cat’s Claw inhibits TNFα production and scavenges free radicals: role in cytoprotection. Free Radical Biology andMedicine,29(1), 71-78. Full Article

IMMUNOMODULATING

Lozada-Requena,I., Núñez, C., Alvárez, Y., Kahn, L., & Aguilar, J. (2015). Lymphocyte subsets, dendritic cellsand cytokine profiles in mice with melanoma treated with Uncaria tomentosa. RevistaPeruana de Medicina Experimental y Salud Publica, 32(4), 633-642.(Spanish). Full Article

Núñez,C., Lozada-Requena, I., Ysmodes, T., Zegarra, D., Saldaña, F., & Aguilar,J. (2015). Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer. Revista Peruana de Medicina Experimental y Salud Publica, 32(4), 643-651. Full Article

Montserrat-DeLa Paz, S., De la Puerta, R., Fernandez-Arche, A., Quilez, A. M., Muriana, F.J. G., Garcia-Gimenez, M. D., & Bermudez, B. (2015). Pharmacological effects of mitraphylline from Uncaria tomentosa in primary human monocytes: skew toward M2macrophages. Journal of Ethnopharmacology, 170, 128-135. Full Article

Domingues,A., Sartori, A., Valente, L. M. M., Golim, M. A., Siani, A. C., & Viero, R.M. (2011). Uncaria tomentosa Aqueous‐ethanol Extract Triggers an Immunomodulation toward a Th2 Cytokine Profile. Phytotherapy Research, 25(8), 1229-1235. Full Article

Kang,T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ...& Watanabe, H. (2002). Pteropodineand isopteropodine positively modulate the function of rat muscarinic M1 and5-HT2 receptors expressed in Xenopus oocyte. European Journal of Pharmacology,444(1-2), 39-45. Full Article

Karl-HeinzReinhard (1999). Uncaria tomentosa (Willd.) D.C.: Cat's Claw, Una de Gato, or Saventaro. The Journal of Alternative andComplementary Medicine, pp. 143-151 Full Article

Painkiller

Jürgensen, S., DalBó, S., Angers, P.,Santos, A. R. S., & Ribeiro-do-Valle, R. M. (2005). Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosaPharmacology Biochemistry and Behavior, 81(3), 466-477. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video

Patient Reports

"I used it against chronic scalp lesions suspected from EBV and it definitely improved them by 80% in two weeks.  The mechanism of action is to bind with sugars in the viral envelope so I take it on an empty stomach and give it 15 minutes to work before eating anything else."-A.B.

“Hey... This stuff actually works. My family has used it all winter when attacked by the flu virus and remain pleased! Take it right away when the symptoms are first felt. It does wonders.” – V.H

“Love this stuff!!! If you haven't seen the 2 minute YouTube video you should. It wipes out viruses for us just like the video says. I keep it in stock in the house at all times.” – D.T

"LOVE this product!!! I keep this on hand at all times. If you take 30-60 drops of this in water at the onset of cold or flu, it will knock it out!!!! AWESOME RESULTS!!"-S.A.

"This stuff actually works. My family has used it all winter when attacked by the flu virus and remain pleased! Take it right away when the symptoms are first felt. It does wonders."-V.H.

Dosage Information

Acute Infections: 30 drops every hour. 

Chronic Infections: 30 drops 2-4 times daily at least 30 minutes before a meal and/or at bedtime.

Protocols

ARTHRITIS (OSTEO AND RHEUMATOID)

ATHEROSCLEROTIC DISEASE

BREAST CANCER

DIABETES (TYPE1 AND TYPE 2)

HEADACHES (SEVERE)

HEPATITIS C

HERPES (GENITAL)

MENINGITIS (VIRAL)

PROSTATE CANCER

VIRAL INFECTIONS (ACUTE-COLDS AND FLU)

Safety Information

An Acute Oral toxicity study was conducted by the Department of Chemical Sciences at the University of Guayaquil, Ecuador.  The general conclusion was that Takuna did not produce toxic effects when used in accordance to the guidelines described in OECD TG 423, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary. Full Article 

Product Label

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TAKUNA
Takuna: Acute Oral Toxicity

Takuna will be used in humans because of the vital importance of carrying out these first-step tests. They will not only guarantee the quality of the product, but will also establish that there are no adverse side effects in humans who take the product. As discussed in numerous international works, the study of acute toxicity is indispensable, and guarantees (within the margin of error associated with the technique) that the potential for toxicity from the compounds that will be ingested or that may enter into the system accidentally will be learned.

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Takuna: Anti-Inflammatory Effect

The auricular edema is achieved by applying 12-0- Tetradecanoil Forbol-13 Acetate (TPA), one of the components responsible for the irritating action of croton oil, into the auditory pavilion of the mouse. The inflammatory reaction consists of erythema , edema and infiltration by polymorphonuclear leukocytes. As such, eicosanoid -type mediators are freed, inducing degranulation of the mast cell. This technique thus allows the evaluation of the inhibiting substances of the biosynthesis of prostaglandins and leukotrienes.

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