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ADRENAL

ADRENAL SUPPORT

TO RESOLVE:

  • ‍ADRENAL FATIGUE
  • ‍EXHAUSTION

TO RESTORE:

  • ENERGY
  • STAMINA
  • ENDURANCE

General Description

Adrenal is a proprietary blend of the extracts of four adaptogenic plants – Panax quinquefolium, Astragalus mongholicus, Schisandra Chinensis, and Rhodiola Rosea. This proprietary blend supplies energy and replenishes depleted adrenal glands.  The adrenal glands help the body respond to stress and also produce steroids that contribute to the production of over 100 hormones that are vital to optimum health. It is estimated that approximately 95% of the population of the United States suffers from some degree of Adrenal Fatigue which is any decrease in the ability of the adrenal glands to perform normal functions.

Some Reported Medicinal Properties

ADAPTOGENIC

ANTIOXIDANT

ANTISPASMODIC

ANTISEPTIC

APHRODISIAC

CARMINATIVE

DEMULCENT

DIAPHORETIC

DIURETIC

EXPECTORANT

HYPOTENSIVE

NERVINE

STIMULANT

STOMACHIC

VASODILATOR

Reasearch On Nutramedix Product

Medical Conditions [peer-reviewed journals]

ANXIETY

Bystritsky, A., Kerwin, L., & Feusner, J. D. (2008). A pilot study of Rhodiola rosea (Rhodax®) for generalized anxiety disorder (GAD). The Journal of Alternative and Complementary Medicine, 14(2), 175-180. Full Article

ALZHEIMER DISEASE

Hu, D., Cao, Y., He, R., Han, N., Liu, Z., Miao, L., & Yin, J. (2012). Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ 1–42-induced memory impairment in mice. Oxidative Medicine and Cellular Longevity, 2012. Full Article

BLADDER CANCER

Liu, Z., Li, X., Simoneau, A. R., Jafari, M., & Zi, X. (2012). Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy. Molecular Carcinogenesis, 51(3), 257-267. Full Article

BREAST CANCER

Qiu, Y. K., Dou, D. Q., Cai, L. P., Jiang, H. P., Kang, T. G., Yang, B. Y., ... & Li, M. Z. (2009). Dammarane-type saponins from Panax quinquefolium and their inhibition activity on human breast cancer MCF-7 cells. Fitoterapia, 80(4), 219-222. Full Article

Wang, C. Z., Aung, H. H., Zhang, B., Sun, S., Li, X. L., He, H., ... & Yuan, C. S. (2008). Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells. Anticancer Research, 28(5A), 2545-2551. Full Article

CARDIAC STIFFNESS

Mucalo, I., Jovanovski, E., Rahelić, D., Božikov, V., Romić, Ž., & Vuksan, V. (2013). Effect of American ginseng (Panax quinquefolius L.) on arterial stiffness in subjects with type-2 diabetes and concomitant hypertension. Journal of Ethnopharmacology, 150(1), 148-153. Full Article

DEPRESSION

Darbinyan, V., Aslanyan, G., Amroyan, E., Gabrielyan, E., Malmström, C., & Panossian, A. (2007). Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nordic Journal of Psychiatry, 61(5), 343-348. Full Article

DIABETES

Vuksan, V., Sievenpiper, J. L., Koo, V. Y., Francis, T., Beljan-Zdravkovic, U., Xu, Z., & Vidgen, E. (2000). American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 diabetes mellitus. Archives of Internal Medicine, 160(7), 1009-1013. Full Article

INFLUENZA

Jeong, H. J., Ryu, Y. B., Park, S. J., Kim, J. H., Kwon, H. J., Kim, J. H., ... & Lee, W. S. (2009). Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorganic & Medicinal Chemistry, 17(19), 6816-6823. Full Article

MEMORY LOSS

Giridharan, V. V., Thandavarayan, R. A., Sato, S., Ko, K. M., & Konishi, T. (2011). Prevention of scopolamine-induced memory deficits by schisandrin B, an antioxidant lignan from Schisandra chinensis in mice. Free Radical Research, 45(8), 950-958. Full Article

Scholey, A., Ossoukhova, A., Owen, L., Ibarra, A., Pipingas, A., He, K., ... & Stough, C. (2010). Effects of American ginseng (Panax quinquefolius) on neurocognitive function: an acute, randomised, double-blind, placebo-controlled, crossover study. Psychopharmacology, 212(3), 345-356. Full Article

Tohda, C., Tamura, T., Matsuyama, S., & Komatsu, K. (2006). Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus. British Journal of Pharmacology, 149(5), 532-541. Full Article

 

Medicinal Properties [peer-reviewed journals]

ANTIOXIDANT

Cheng, N., Ren, N., Gao, H., Lei, X., Zheng, J., & Cao, W. (2013). Antioxidant and hepatoprotective effects of Schisandra chinensis pollen extract on CCl4-induced acute liver damage in mice. Food and Chemical Toxicology, 55, 234-240. Full Article

Battistelli, M., De Sanctis, R., De Bellis, R., Cucchiarini, L., Dachà, M., & Gobbi, P. (2009). Rhodiola rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour. European Journal of Histochemistry, 49(3), 243-254. Full Article

Chen, C. F., Chiou, W. F., & Zhang, J. T. (2008). Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacologica Sinica, 29(9), 1103. Full Article

Kim, S. H., Hyun, S. H., & Choung, S. Y. (2006). Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors, 26(3), 209-219. Full Article

Yu, D., Duan, Y., Bao, Y., Wei, C., & An, L. (2005). Isoflavonoids from Astragalus mongholicus protect PC12 cells from toxicity induced by L-glutamate. Journal of Ethnopharmacology, 98(1-2), 89-94. Full Article

De Sanctis, R., De Bellis, R., Scesa, C., Mancini, U., Cucchiarini, L., & Dachà, M. (2004). In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes. Biofactors, 20(3), 147-159. Full Article

Kim, S. R., Lee, M. K., Koo, K. A., Kim, S. H., Sung, S. H., Lee, N. G., ... & Kim, Y. C. (2004). Dibenzocyclooctadiene lignans from Schisandra chinensis protect primary cultures of rat cortical cells from glutamateinduced toxicity. Journal of Neuroscience Research, 76(3), 397-405. Full Article

Ng, T. B., Liu, F., & Wang, H. X. (2004). The antioxidant effects of aqueous and organic extracts of Panax quinquefolium, Panax notoginseng, Codonopsis pilosula, Pseudostellaria heterophylla and Glehnia littoralis. Journal of Ethnopharmacology, 93(2-3), 285-288. Full Article

ANTIPROLIFERATIVE

Min, H. Y., Park, E. J., Hong, J. Y., Kang, Y. J., Kim, S. J., Chung, H. J., ... & Kang, S. S. (2008). Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells. Bioorganic & Medicinal Chemistry Letters, 18(2), 523-526. Full Article

Majewska, A., Grażyna, H., Mirosława, F., Natalia, U., Agnieszka, P., Alicja, Z., & Kuraś, M. (2006). Antiproliferative and antimitotic effect, S phase accumulation and induction of apoptosis and necrosis after treatment of extract from Rhodiola rosea rhizomes on HL-60 cells. Journal of Ethnopharmacology, 103(1), 43-52. Full Article

ANTITUMOR

Zhao, T., Mao, G., Mao, R., Zou, Y., Zheng, D., Feng, W., ... & Chen, Y. (2013). Antitumor and immunomodulatory activity of a water-soluble low molecular weight polysaccharide from Schisandra chinensis (Turcz.) Baill. Food and Chemical Toxicology, 55, 609-616. Full Article

ANTIFATIGUE

Qi, B., Liu, L., Zhang, H., Zhou, G. X., Wang, S., Duan, X. Z., ... & Zhao, D. Q. (2014). Anti-fatigue effects of proteins isolated from Panax quinquefolium. Journal of Ethnopharmacology, 153(2), 430-434. Full Article

Barton, D. L., Liu, H., Dakhil, S. R., Linquist, B., Sloan, J. A., Nichols, C. R., ... & Loprinzi, C. L. (2013). Wisconsin Ginseng (Panax quinquefolius) to improve cancer-related fatigue: a randomized, double-blind trial, N07C2. Journal of the National Cancer Institute, 105(16), 1230-1238. Full Article

Ishaque, S., Shamseer, L., Bukutu, C., & Vohra, S. (2012). Rhodiola rosea for physical and mental fatigue: a systematic review. BMC Complementary and Alternative Medicine, 12(1), 70. Full Article

Barton, D. L., Soori, G. S., Bauer, B. A., Sloan, J. A., Johnson, P. A., Figueras, C., ... & Christensen, B. (2010). Pilot study of Panax quinquefolius (American ginseng) to improve cancer-related fatigue: a randomized, double-blind, dose-finding evaluation: NCCTG trial N03CA. Supportive Care in Cancer, 18(2), 179. Full Article

Shevtsov, V. A., Zholus, B. I., Shervarly, V. I., Vol'skij, V. B., Korovin, Y. P., Khristich, M. P., ... & Wikman, G. (2003). A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine, 10(2-3), 95-105. Full Article

Darbinyan, V., Kteyan, A., Panossian, A., Gabrielian, E., Wikman, G., & Wagner, H. (2000). Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine, 7(5), 365-371. Full Article

Spasov, A. A., Wikman, G. K., Mandrikov, V. B., Mironova, I. A., & Neumoin, V. V. (2000). A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine, 7(2), 85-89. Full Article

ANTIFUNGAL

Yan, Q., Jiang, Z., Yang, S., Deng, W., & Han, L. (2005). A novel homodimeric lectin from Astragalus mongholicus with antifungal activity. Archives of Biochemistry and Biophysics, 442(1), 72-81. Full Article

ANTI-INFLAMMATORY

Oh, S. Y., Kim, Y. H., Bae, D. S., Um, B. H., Pan, C. H., Kim, C. Y., ... & Lee, J. K. (2010). Anti-inflammatory effects of gomisin N, gomisin J, and schisandrin C isolated from the fruit of Schisandra chinensis. Bioscience, Biotechnology, and Biochemistry, 74(2), 285-291. Full Article

Bawa, A. S., & Khanum, F. (2009). Antiinflammatory activity of Rhodiola rosea–“a secondgeneration adaptogen”. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 23(8), 1099-1102. Full Article

Guo, L. Y., Hung, T. M., Bae, K. H., Shin, E. M., Zhou, H. Y., Hong, Y. N., ... & Kim, Y. S. (2008). Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill. European Journal of Pharmacology, 591(1-3), 293-299. Full Article

ANTICONVULSIVE

Jalsrai, A., Grecksch, G., & Becker, A. (2010). Evaluation of the effects of Astragalus mongholicus Bunge saponin extract on central nervous system functions. Journal of Ethnopharmacology, 131(3), 544-549. Full Article

ANXIOLYTIC EFFECT

Wei, X. Y., Yang, J. Y., Wang, J. H., & Wu, C. F. (2007). Anxiolytic effect of saponins from Panax quinquefolium in mice. Journal of Ethnopharmacology, 111(3), 613-618. Full Article

ADAPTOGENIC EFFECT

Perfumi, M., & Mattioli, L. (2007). Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 21(1), 37-43. Full Article

MITOCHONDRIAL SUPPORT

Abidov, M., Crendal, F., Grachev, S., Seifulla, R., & Ziegenfuss, T. (2003). Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bulletin of Experimental Biology and Medicine, 136(6), 585-587. Full Article

IMMUNOMODULATING

Wang, M., Guilbert, L. J., Ling, L., Li, J., Wu, Y., Xu, S., ... & Shan, J. J. (2001). Immunomodulating activity of CVTE002, a proprietary extract from North American ginseng (Panax quinquefolium). Journal of Pharmacy and Pharmacology, 53(11), 1515-1523. Full Article

RELAXANT

Mattioli, L., Funari, C., & Perfumi, M. (2009). Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. Journal of Psychopharmacology, 23(2), 130-142. Full Article

Mattioli, L., & Perfumi, M. (2007). Rhodiola rosea L. extract reduces stress-and CRF-induced anorexia in rats. Journal of Psychopharmacology, 21(7), 742-750. Full Article

VARIOUS PROPERTIES

Khanum, F., Bawa, A. S., & Singh, B. (2005). Rhodiola rosea: a versatile adaptogen. Comprehensive Reviews in Food Science and Food Safety, 4(3), 55-62. Full Article

 

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Patient Reports

"I have Lyme disease and struggle with the chronic fatigue it causes. My adrenals and thyroid are just spent. This product was recommended by my doctor. It made a huge difference in my daily life." -N.S.

“Immensely helpful for someone like me with Chronic Lyme. I take 10 drops per day, which is less than the recommended dose.” -J.M.

“Does the job! In fact, since using this, my morning cortisol has tested in the optimal zone for the first time in nearly a decade. Yay!!!” – E.S

"Love this product. It has helped me immensely with Adrenal Fatigue. I take twice a day every day and I have much more energy than I had before." -K.M. 

"I found that this was helpful for me in my healing and use it regularly. If you have adrenal fatigue and are dealing with Lyme I recommend it." -L.R.

Dosage Information

20 drops in 4 oz. of water 2 times per day (breakfast and lunch are preferable). 

Higher doses may be used if recommended by a qualified healthcare practitioner.

Protocols

Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Adrenal did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.

Product Label

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ADRENAL
Adrenal: Schisandra chinensis - Anti-inflammatory (Schisandra)

Schisandra chinensis is generally used as a tonic medicine in Korea and it is a medical plant used in Chinese medicine. Infusions, decoctions, tinctures, and extracts from different parts of schisandra include large percentages of ether oils, resins, trace amounts of vitamin C, tannins, and staining materials, and large amounts of lipid soluble compounds. Moreover, Schisandra chinensis fruits contain a variety of pharmacologically active lignans. These compounds have various pharmacological activities, including detoxificant, antioxidant, anticarcinogenic, antihepatotoxic, and anti-inflammatory activities.

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Adrenal: Rhodiola rosea - Mitochondrial support

Treatment with R. rosea extract significantly (by 24.6%) prolonged the duration of exhaustive swimming in comparison with control rate and rats treated with R. crenulata. R rosea extract activated the synthesis or resynthesis of ATP in mitochondria and stimulated reparative energy processes after intense exercise. Experiments proved different pharmacological characteristics of R. rosea and R. crenulata: R. rosea is most effective for improving physical working capacity.

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Adrenal: Rhodiola rosea - antifatigue (standardised)

Stress-related fatigue is a widespread problem in the Western world. Psychological stress, for example, can often induce long-term exhaustion and diminished interest, producing a condition known as burnout syndrome. The aim of the study was to assess the efficacy of the standardised extract SHR-5 of roots of Rhodiola rosea L. in the treatment of individuals suffering from stress-related fatigue.

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Adrenal: Panax quinquefolius - Diabetes (Type 2)

Ginseng, one of the most widely used herbs, is hypothesized to play a role in carbohydrate metabolism and diabetes mellitus. We therefore undertook a preliminary short-term clinical study to assess whether American ginseng (Panax quinquefolius L) affects postprandial glycemia in humans.

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Adrenal: Panax quinquefolius - Antifatigue (NCCTG)

This pilot trial sought to investigate whether any of three doses of American ginseng (Panax quinquefolius) might help cancer-related fatigue. A secondary aim was to evaluate toxicity.‍

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Adrenal: Astragalus mongholicus - Antifungal

Lectins constitute a class of proteins which possess at least one noncatalytic domain capable of specific recognition and reversible binding to carbohydrate. They have attracted great interest because of their various bio-logical activities, such as cell agglutination, antiprolifera-tive,antitumor, immunomodulatory, antifungal, and antiviral. So far, a number of lectins have been iso-lated and characterized from leguminous species mainly on the basis of hemagglutinating activity.

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Adrenal: Schisandra chinensis - Memory Loss (SchB)

The preventive effect of schisandrin B (Sch B), an antioxidant ingredient of Schisandra chinensis, was studied on scopolamine-induced dementia in mouse.

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Adrenal: Schisandra chinensis - Antitumor

A water-soluble low molecular weight polysaccharide (SCPP11) was extracted and purified using DEAEcellulose and Sephadex G-100 column from Schisandra chinensis (Turcz.) Baill. Its in vivo and in vitro antitumor and immunomodulatory activity were investigated.

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Adrenal: Schisandra chinensis - Antiproliferative

Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative effects in various human cancer cells.

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Adrenal: Schisandra chinensis - Antioxidant (cultures)

A methanolic extract of dried Schisandra fruit (Schisandra chinensis Baill.; Schisandraceae) significantly attenuated the neurotoxicity induced by L-glutamate in primary cultures of rat cortical cells.

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Adrenal: Schisandra chinensis - Antioxidant (pollen)

The aim of the present study was to investigate the antioxidant and hepatotective effects of Schisandra chinensis pollen extract (SCPE) on CCl4-induced acute liver damage in mice.

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Adrenal: Schisandra chinensis - Anti-inflammatory

In the present study, the effect of schisandrin on plasma nitrite concentration in lipopolysaccharide (LPS)-treated mice was evaluated. It also significantly inhibited carrageenan-induced paw edema and acetic acid-induced vascular permeability in mice.

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Adrenal: Schisandra chinensis - Alzhiemer

In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta1–42- (Aβ1–42-) induced memory impairment in mice and elucidated the possible antioxidative mechanism.

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Adrenal: Rhodiola rosea Antioxidant (Liver)

This study was designed to examine the effects of Cinnamomi cassiae and Rhodiola rosea extracts on blood glucose, lipid peroxidation, the level of reduced glutathione and its related enzymes (glutathione reductase, glutathione S-transferase), and the activity of the antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase) in the liver of db/db mice.

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Adrenal: Rhodiola rosea - Various Properties

Rhodiola rosea (rose root) belonging to the family Crassulaceae is a popular medicinal plant in Russia, Scandinavia, and many other countries. Extracts of the roots of this plant have been found to favorably affect a number of physiological functions including neurotransmitter levels, central nervous system activity, and cardiovascular function.

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Adrenal: Rhodiola rosea - Relaxant

The aim of this study was to determine whether chronic treatment with a hydroalcoholic R. rosea extract (RHO) standardized in 3% rosavin and 1% salidroside can prevent alterations induced in female rats following 6 weeks of a chronic mild stress (CMS) procedure.

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Adrenal: Rhodiola rosea - Relaxant (Stress)

The aim of this work was thus to determine whether in rats an hydroalcoholic R. rosea extract standardized in 3% rosavin and 1% salidroside (RHO) reverses hypophagia induced by (1) physical stress due to 60 min immobilization; (2) intracerebroventricular injection of corticotrophinreleasing factor (CRF,0.2 f..l.g/rat), the major mediator of stress responses in mammals; (3) intraperitoneal injection of Escherichia coli lipopolysaccharide (LPS, 100 f..l.g/kg); (4) intraperitoneal administration of fluoxetine (FLU, Brng/kg).

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Adrenal: Rhodiola rosea - Influenza

The in vitro anti-influenza virus activities of flavonoids 1–6, 8–12, and 14 were evaluated using two influenza viral strains, H1N1 (A/PR/8/34) and H9N2 (A/Chicken/Korea/MS96/96), testing their ability to reduce virus-induced cytopathic effect (CPE) in MDCK cells.

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Adrenal: Rhodiola rosea - Depression

The objective of this study was to assess the efficacy and safety of standardized extract SHR-5 of rhizomes of Rhodiola rosea L. in patients suffering from a current episode of mild/moderate depression.

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Adrenal: Rhodiola rosea - Bladder Cancer (mTOR)

We demonstrated that a R. rosea extract and one of its bioactive components, salidroside, inhibited the growth of bladder cancer cell lines with a minimal effect on nonmalignant bladder epithelial cells TEU-2. Interestingly, the R. rosea extract and salidroside component exhibited a selective ability to inhibit the growth of p53 knockout primary mouse embryo fibroblasts (p53/ MEFs) compared to their wild-type counterparts.

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Adrenal: Rhodiola rosea - Anxiety

Rhodiola rosea is an herbal supplement that many in the general population in Russia and elsewhere in the world have used for decades to alleviate everyday anxiety, depression, and insomnia. Whether R. rosea is effective in reducing similar symptoms in clinical samples is unknown. The goal of this pilot study was to evaluate whether R. rosea is effective in reducing symptoms of generalized anxiety disorder (GAD).

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Adrenal: Rhodiola rosea - Antiproliferative

The cytostatic and antiproliferative effect of the Rhodiola rosea rhizome extract, and its mild action, raises hope for its use in anticancer therapy by enhancing the effectiveness of cytostatics.

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Adrenal: Rhodiola rosea - Antioxident (red blood)

The aim of the present study was to investigate the effect of the R. rosea roots aqueous extract on in vitro human erythrocytes exposed to hypochlorous acid (HOCl)-oxidative stress.

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Adrenal: Rhodiola rosea - Antioxident (erythrocytes)

Our study demonstrates that R. rosea is able to significantly protect, in a dose-dependent manner, human RBC from glutathione (GSH) depletion, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inactivation and hemolysis induced by the oxidant. Furthermore, we demonstrate that R. rosea aqueous extract acts from the inside of the erythrocyte suggesting a probable involving of cell components.

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Adrenal: Rhodiola rosea - Anti-inflammatory (second)

The in vitro inhibitory effects of the tincture extract from R. rosea roots was evaluated against the enzymes relating to inflammation. The enzymes include cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2) and Phospholipase A2 (PLA2). The extract showed varying inhibitory activities against these enzymes depending on the concentrations.

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Adrenal: Rhodiola rosea - antifatigue (SHR-5)

The aim of this study was to investigate the effect of repeated low-dose treatment with a standardized extract SHR/5 of rhizome Rhodiola rosea L, (RRE) on fatigue during night duty among a group of 56 young, healthy physicians.

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Adrenal: Rhodiola rosea - antifatigue (review)

Due to its purported adaptogenic properties, it has been studied for its performance-enhancing capabilities in healthy populations and its therapeutic properties in a number of clinical populations. To systematically review evidence of efficacy and safety of R. rosea for physical and mental fatigue.

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Adrenal: Rhodiola rosea - antifatigue (mental work)

A randomized, double-blind, placebo-controlled, parallel-group clinical study with an extra nontreatment group was performed to measure the effect of a single dose of standardized SHR-5 Rhodiola rosea extract on capacity for mental work against a background of fatigue and stress.

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Adrenal: Rhodiola rosea - antifatigue (double)

The aim of this study was to investigate the effect of a repeated low-dose regimen of a special extract of Rhodiola rosea radix, SHR- 5, on a group of students from India, during an exam period with respect to both physical fitness and mental well-being and capacity.

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Adrenal: Rhodiola rosea - Adaptogenic

Some preclinical and clinical studies of R. rosea extracts have provided evidence for a number of pharmacological activities, including adaptogenic, antistress, antihypoxic, antioxidant, anticancer, learning and memory enhancing and immune and sexual stimulating effects (Petkov et al., 1986; Darbinyan et al., 2000; Ming et al., 2005; Panossian and Wagner, 2005).

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Adrenal: Panax quinquelfolium - Antioxidant (comparison)

P ginseng and P quinquefolium are general tonics and adaptogens. Rg1 and Rb1 enhance central nervous system (CNS) activities, but the effect of the latter is weaker. Thus, for the higher contents of Rg1, P ginseng is a stimulant, whereas the Rb1 contents of P quinquefolium are mainly calming to the CNS.

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Adrenal: Panax quinquefolius - stiffness

Accumulating clinical evidence concerning the potential benefits of ginseng roots in vascular pathology imply that ginseng species might improve endothelial dysfunction and arterial stiffness in healthy individuals (Jovanovski et al., 2010) and patients with hypertension and type 2 diabetes by increasing NO bioavailability and preventing free radical injury to the vascular endothelium (Han et al., 2005; Lee and Son, 2011; Xu et al., 2000).

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Adrenal: Panax quinquefolius - Antifatigue (wisconsin)

Dietary supplements are a popular self-administered remedy among patients for symptoms that have no known effective treatment; CRF is no exception. Coenzyme Q 10, L-Carnitine, guarana, and ginseng have been used for fatigue and subsequently studied. Based on their role in cellular energy production, both coenzyme Q 10 and L-Carnitine were evaluated in placebo-controlled trials for CRF; they were found to be no more helpful than placebos (19,20). Guarana has supportive data from a phase II placebo-controlled trial (21), warranting further research.

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Adrenal: Panax quinquefolius - Antifatigue (V79-4)

Heat-processed Asian ginseng roots (Panax ginseng C.A. Meyer), also known as “red ginseng” in Asia, are reported to have more bioactivity than the no-processed white ginseng roots. Therefore, American fresh ginseng roots (Panax quinquefolius L.) were processed to the red ginseng and examined changes in bioactivity during heating process.

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Adrenal: Panax quinquefolium - Memory Loss (neurocognitive)

Empirical studies have attributed these effects to the action of a group of ginseng-specific saponins known as ginsenosides. There is a growing body of evidence to support Panax ginseng (Asian ginseng) as a cognitive enhancer; Panax quinquefolius (American ginseng) is another prominent species with a ginsenosides profile distinct to that of P. ginseng.

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Adrenal: Panax quinquefolium - Immunomodulating

Panax ginseng C. A. Meyer, commonly called ginseng, has been traditionally used to prevent and treat many kinds of diseases in Asia. Ginseng activity has been characterized by biochemical, immunological and pharmacological methods. Two main medicinal fractions derive from ginseng root processing. One fraction is composed of complex water-soluble polysaccharides and oligosaccharides and the other contains ginsenosides.

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Adrenal: Panax quinquefolium - Breast Cancer

Panax quinquefolium, known as American ginseng, has been used for stress and fatigue characterized by insomnia, poor appetite, nervousness, and restlessness. It has been used for conditions of weakness, convalescence, low resistance, poor immunity or debility due to chronic disease.

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Adrenal: Panax quinquefolium - Breast Cancer (Heat)

Asian ginseng has many reported health benefits, including anticancer activities (4-6). In the 1990s, a case–control study on over a thousand Korean subjects showed that long-term ginseng consumption was associated with a decreased risk for many different malignancies (7, 8). In contrast to many studies on Asian ginseng’s anticancer effects, investigation of American ginseng is limited (4) and its mechanisms of action are largely unknown.

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Adrenal: Panax quinquefolium - Anxiolytic

The anxiolytic effect of the saponins from Aniliaeea Panax quinquefolium L. (PQS) was studied in male mice by using a number of experimental paradigms of anxiety and compared with that of the known anxiolytic compound diazepam. Use of the elevated plus-maze test revealed that PQS (50 mg/kg, p.o.) and diazepam (2.5 mg/kg, p.o.) increased the percentage of time and entries spent in open arms.

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Adrenal: Panax quinquefolium - Antioxidant (organic)

The roots of Panax quinquefolium, Panax notoginseng, Glehnia littoralis, Codonopsis pilosula and Pseudostellaria heterophylla were extracted with an aqueous extraction method and also with an organic extraction method. The aqueous extracts of Glehnia littoralis and Codonopsis pilosula were the most potent in inhibiting erythrocyte hemolysis.

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Adrenal: Panax quinquefolium - Antifatigue

American ginseng is the root of Panax quinquefolium, which is currently grown in Canada and eastern USA, similar to Panax ginseng C.A. Meyer. It is an obligate shade perennial plant. American ginseng is a traditional valuable herb, which belongs to Araliaceae ginseng species. It contains various active constituents such as ginsenosides, polysaccharides, polyacetylenes, phenoliccompounds, peptides and essential oils (Lemmon et al., 2012; Yooet al., 2012; Trammell et al., 2012).

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Adrenal: Astragalus mongholicus - Memory loss

Neurons with atrophic neurites may remain alive and therefore may have the potential to regenerate even when neuronal death has occurred in some parts of the brain. We have hypothesized that reconstructing neuronal networks in the injured brain is essential for the recovery of brain function (Tohda et al., 2005).

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Adrenal: Astragalus mongholicus - Antioxidant (Astragalus PC12)

Astragalus mongholicus Bunge (Leguminosae), known as Huangqi in China, has been used as one of the primary Chinese tonic herbs with a history of thousands of years (Roy and Cathiroe, 1999). In modern Chinese medicine, Huangqi is widely used as an immune modulator, especially to support immune health for various chronic degenerative diseases.

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Adrenal: Astragalus mongholicus - Anti-Convlusive

It was shown that AM (50, 100, 200 mg/kg) did not interfere with locomotor activity and situational anxiety as measured in the elevated plus maze. In these doses, AM significantly suppressedpentylenetetrazole (PTZ)-induced seizures (p < 0.05). Its anticonvulsant efficacy was also evident againstrepeated PTZ seizures (p < 0.05). This suggests potential therapeutic usefulness. After subchronic application, the number of cells in hippocampal CA1 was reduced, whilst the cell number in CA3 and hilusremained unaffected.

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