UP
FOR PROMTING HEALTHY MICROBIAL RESPONSE, ANTIVIRAL RESPONSE, IMMUNE SYSTEM STIMULATING AND IMMUNE MODULATING
Methyl Complete is the combination of riboflavin, pyridoxal 5'-phosphate, L-methylfolate, methylcobalamin, creatine monohydrate, and betaine anhydrous. These ingredients offer comprehensive support for energy production, nervous system function, and methylation pathways. Riboflavin (vitamin B2) plays a key role in converting nutrients into energy and supports antioxidant activity, helping protect cells from oxidative stress. Pyridoxal 5'-phosphate, the active form of vitamin B6, is essential for amino acid metabolism, neurotransmitter synthesis, and maintaining healthy homocysteine levels, all of which are important for cardiovascular and neurological health.
L-methylfolate, the active and bioavailable form of folate, is critical for DNA synthesis, cellular repair, and methylation—a process that supports detoxification, gene expression, and mood regulation. When paired with methylcobalamin, the active form of vitamin B12, these nutrients further promote red blood cell formation, neurological function, and cognitive clarity.
Creatine monohydrate and betaine anhydrous complement this formula by supporting cellular energy and muscle function. Creatine helps recycle ATP, the body’s main energy molecule, particularly in muscle and brain tissues, which can enhance performance, recovery, and mental clarity. Betaine anhydrous (trimethylglycine) contributes to healthy methylation and liver function and also plays a role in hydration and muscle strength.
ENERGY PRODUCTION
METHYLATION SUPPORT
HOMOCYSTEINE REGULATION
NEUROTRANSMITTER SYNTHESIS
COGNITIVE SUPPORT
CARDIOVASCULAR HEALTH
ANTIOXIDANT ACTIVITY
DNA SYNTHESIS
MUSCLE STRENGTH
CELLULAR HYDRATION
RED BLOOD CELL FORMATION
LIVER FUNCTION
MOOD REGULATION
NERVOUS SYSTEM SUPPORT
Valayannopoulos, V., Schiff, M., Guffon, N., Nadjar, Y., García-Cazorla, A., Martinez-Pardo Casanova, M., Cano, A., Couce, M. L., Dalmau, J., Peña-Quintana, L., Rigalleau, V., Touati, G., Aldamiz-Echevarria, L., Cathebras, P., Eyer, D., Brunet, D., Damaj, L., Dobbelaere, D., Gay, C., ... Maillot, F. (2019). Betaine anhydrous in homocystinuria: Results from the RoCH registry. Orphanet Journal of Rare Diseases, 14(66). Full Article
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Amenyah, S. D., McMahon, A., Ward, M., Deane, J., McNulty, H., Hughes, C. F., Strain, J. J., Horigan, G., Purvis, J., Walsh, C. P., & Lees-Murdock, D. J. (2020). Riboflavin supplementation alters global and gene-specific DNA methylation in adults with the MTHFR 677 TT genotype. Biochimie, 173, 17–26. Full Article
Anderson, O. S., Sant, K. E., & Dolinoy, D. C. (2012). Nutrition and epigenetics: An interplay of dietary methyl donors, one-carbon metabolism and DNA methylation. Journal of Nutritional Biochemistry, 23(7), 853–859. Full Article
Jacques, P. F., Kalmbach, R., Bagley, P. J., Russo, G. T., Rogers, G., Wilson, P. W. F., Rosenberg, I. H., & Selhub, J. (2002). The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring Cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene. The Journal of Nutrition, 132(2), 283–288.
Dalto, D. B., & Matte, J.-J. (2017). Pyridoxine (Vitamin B6) and the Glutathione Peroxidase System; a link between one-carbon metabolism and antioxidation. Nutrients, 9(3), 189. Full Article
Stach, K., Stach, W., & Augoff, K. (2021). Vitamin B6 in health and disease. Nutrients, 13(9), 3229. Full Article
Almeida, D., Colombini, A., & Machado, M. (2020). Creatine supplementation improves performance, but is it safe? A double-blind placebo-controlled study. Journal of Sports Medicine and Physical Fitness, 60(7), 1034–1039. Full Article
Ostojic, S. M. (2021). Creatine as a food supplement for the general population. Journal of Functional Foods, 83, 104568. Full Article
Vaccaro, J. A., & Naser, S. A. (2022). The role of methyl donors of the methionine cycle in gastrointestinal infection and inflammation. Healthcare, 10(1), 61. Full Article
Salazar, J. H. (2014). Overview of Urea and Creatinine. Lab Medicine, 45(1), e19–e20. Full Article
Craig, S. A. S. (2004). Betaine in human nutrition. The American Journal of Clinical Nutrition, 80(3), 539–549. Full Article
Bozack, A. K., Howe, C. G., Hall, M. N., Liu, X., Slavkovich, V., Ilievski, V., Lomax-Luu, A. M., Parvez, F., Siddique, A. B., Shahriar, H., Uddin, M. N., Islam, T., Graziano, J. H., & Gamble, M. V. (2021). Betaine and choline status modify the effects of folic acid and creatine supplementation on arsenic methylation in a randomized controlled trial of Bangladeshi adults. European Journal of Nutrition, 60, 1921–1934. Full Article
Zhou, R.-f., Chen, X.-L., Zhou, Z.-g., Zhang, Y.-j., Lan, Q.-y., Liao, G.-c., Chen, Y.-m., & Zhu, H.-l. (2017). Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: A case-control study. Scientific Reports, 7, 679. Full Article
Take two capsules once or twice daily or as directed by your physician
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