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CUMANDA

MICROBIAL DEFENSE

TO RESOLVE:

  • BACTERIAL INFECTIONS
  • FUNGAL INFECTIONS
  • PARASITIC INFECTIONS
  • ‍VIRAL INFECTIONS
  • INFLAMMATION
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General Description

Cumanda is an herbal extract made from the bark of the Campsiandra Angustifolia tree, found in South America. It has been used by indigenous groups in that region for hundreds of years. Cumanda is very effective in treating the Borrelia burgdorferi bacteria and practitioners are now using it in conjunction with Samento to treat Lyme Borreliosis with co-infections. Lyme Borreliosis has been linked to hundreds of medical conditions. Many researchers and physicians believe that Lyme Borreliosis may be a factor in most chronic conditions. One of the most impressive benefits of Cumanda is its antifungal action. Physicians report that it is effective in treating many difficult to treat fungi including Mycosis fungoides, Candida krusei, Candida albicans and Aspergillus niger, to name a few.

Some Reported Medicinal Properties

ANTIBACTERIAL

ANTIFUNGAL

ANTIVIRAL

ANTIPARASITIC

ANTI-INFLAMMATORY

ANALGESIC

IMMUNE SYSTEM MODULATOR

Research On NutraMedix Product

In vitro – Lyme Disease

Priyanka A.S. Theophilus M.S., Eva Sapi Ph.D. (2013). In Vitro Effect of Peruvian Antimicrobial Agents on Borrelia burgdorferi Full Article

in vivo – Anti-inflammatory

Establishment of the Potential Anti-inflammatory Effect of the product known as Cumanda.  The study demonstrated that Cumanda had a marked anti-inflammatory effect and was 99% as effective as Feldene, a non-steroidal anti-inflammatory drug also known as PIROXICAM. University of Guayaquil, Department of Chemical Sciences, Guayaquil, Ecuador (2005).

At the University of Guayaquil, Ecuador, Cumanda produced an anti-inflammatory effect 112% as strong as Celebrexas an anti-inflammatory. Full Article

IN VIVO ACUTE ORAL TOXICITY TESTS

‍An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Cumanda did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.  Full Article

Medical Conditions [peer-reviewed journals]

Malaria

Roumy, V., Garcia-Pizango, G., Gutierrez-Choquevilca, A. L., Ruiz, L., Jullian, V., Winterton, P., ... & Valentin, A. (2007). Amazonian plants from Peru used by Quechua and Mestizo to treat malaria with evaluation of their activity. Journal of Ethnopharmacology, 112(3), 482-489. Full Article

Kvist, L. P., Christensen, S. B., Rasmussen, H. B., Mejia, K., & Gonzalez, A. (2006). Identification and evaluation of Peruvian plants used to treat malaria and leishmaniasis. Journal of Ethnopharmacology, 106(3), 390-402. Full Article

Medicinal Properties [peer-reviewed journals]

ADJUNCTIVE TO CHEMOTHERAPY

Allen,L., Buckner, A., Buckner, C. A., Cano, P., & Lafrenie, R. M. (2017). Uncaria tomentosa (Willd. ex Schult.) DC (Rubiaceae) sensitizes THP-1 cells to radiation-induced cell deathPharmacognosy Research,9(3), 221. Full Article

Farias,I., do Carmo Araújo, M., Zimmermann, E. S., Dalmora, S. L., Benedetti, A. L.,Alvarez-Silva, M., ... & Schetinger, M. R. C. (2011). Uncaria tomentosa stimulates the proliferation of myeloid progenitor cellsJournal of Ethnopharmacology, 137(1), 856-863. Full Article

ANTIBACTERIAL

Nowakowska,J., Bany, J., Zdanowska, D., Czubaj, A., Kuraś, M., & Skopińska-Różewska, E.(2009). Experimental Immunology: The effect of the bark water extract Uncaria tomentosa on the Pseudomonas aeruginosa infection in mice. Central European Journal of Immunology, 34(3), 162-165. Full Article

ANTIFUNGAL

Moraes,R. C., Carvalho, A. R., Lana, A. J. D., Kaiser, S., Pippi, B., Fuentefria, A.M., & Ortega, G. G. (2017). In vitro synergism of a water insoluble fraction of Uncaria tomentosa combined with fluconazole and terbinafine against resistant non-Candida albicans isolates. Pharmaceutical biology, 55(1), 406-415. Full Article

Moraes,R. C., Dalla Lana, A. J., Kaiser, S., Carvalho, A. R., de Oliveira, L. F. S., Fuentefria, A. M., & Ortega, G. G. (2015). Antifungal activity of Uncaria tomentosa (Willd.) DC against resistant non-albicans Candida isolatesIndustrial Crops and Products,69, 7-14. Full Article

ANTI-INFLAMMATORY

Montserrat-dela Paz, S., Fernandez-Arche, A., de la Puerta, R., Quilez, A. M., Muriana, F.J., Garcia-Gimenez, M. D., & Bermudez, B. (2016). Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine, 23(2), 141-148. Full Article

Rojas-Duran,R., González-Aspajo, G., Ruiz-Martel, C., Bourdy, G., Doroteo-Ortega, V. H.,Alban-Castillo, J., ... & Deharo, E. (2012). Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of Ethnopharmacology, 143(3),801-804. Full Article

Gonçalves,C., Dinis, T., & Batista, M. T. (2005). Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity. Phytochemistry, 66(1), 89-98. Full Article

ANTIGENOTOXIC AND ANTIMUTAGENIC

Paniagua‐Pérez, R., Madrigal‐Bujaidar, E., Molina‐Jasso, D., Reyes‐Cadena, S., Álvarez‐González, I., Sánchez‐Chapul, L., & Pérez‐Gallaga, J. (2009). Antigenotoxic, antioxidant, and lymphocyte induction effects produced by pteropodine. Basic & clinical pharmacology& toxicology, 104(3), 222-227. Full Article

ANTIMICROBIAL

Herrera,D. R., Tay, L. Y., Rezende, E. C., Kozlowski Jr, V. A., & dos Santos, E. B.(2010). In vitro antimicrobial activity of phytotherapic Uncaria tomentosa against endodontic pathogensJournal of oral science,52(3), 473-476. Full Article

ANTINEOPLASTIC

Dreifuss,A. A., Bastos-Pereira, A. L., Fabossi, I. A., dos Reis Lívero, F. A., Stolf, A.M., de Souza, C. E. A., ... & Teixeira, S. (2013). Uncaria tomentosa exerts extensiveanti-neoplastic effects against the Walker-256 tumor by modulating oxidative stress and not by alkaloid activity. PLoS One, 8(2), e54618. Full Article

Rinner,B., Li, Z. X., Haas, H., Siegl, V., Sturm, S., Stuppner, H., & Pfragner, R.(2009). Anti-proliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cellsAnticancer research, 29(11), 4519-4528. Full Article

ANTIOXIDANT

Bukowska,B., Bors, M., Gulewicz, K., & Koter-Michalak, M. (2012). Uncaria tomentosa extracts protect human erythrocyte catalase against damage induced by 2, 4-D-Na and its metabolitesFood and Chemical Toxicology, 50(6), 2123-2127. Full Article

Amaral,S., Mira, L., Nogueira, J. M. F., da Silva, A. P., & Florêncio, M. H.(2009). Plant extracts with anti-inflammatory properties—A new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationshipsBioorganic & Medicinal Chemistry, 17(5), 1876-1883. Full Article

Trejo‐Tapia, G., Sepúlveda‐Jiménez, G., Trejo‐Espino, J. L., Cerda‐García‐Rojas, C. M., De La Torre, M., Rodríguez‐Monroy, M., & Ramos‐Valdivia, A. C. (2007). Hydrodynamic stress induces monoterpenoid oxindole alkaloid accumulation by Uncaria tomentosa (Willd) DCcell suspension cultures via oxidative burst. Biotechnology and Bioengineering,98(1), 230-238. Full Article

Cisneros,F. J., Jayo, M., & Niedziela, L. (2005). An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation. Journal of Ethnopharmacology, 96(3), 355-364. Full Article

CENTRAL NERVOUS SYSTEM (CNS) SUPPORT

Kang,T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ...& Watanabe, H. (2002). Pteropodine and isopteropodine positively modulate the function of rat muscarinic M1 and 5-HT2 receptors expressed in Xenopus oocyteEuropeanjournal of pharmacology, 444(1-2), 39-45. Full Article

CYTOPROTECTIVE

Sandoval,M., Charbonnet, R. M., Okuhama, N. N., Roberts, J., Krenova, Z., Trentacosti,A. M., & Miller, M. J. (2000). Cat’s Claw inhibits TNFα production and scavenges free radicals: role in cytoprotection. Free Radical Biology andMedicine,29(1), 71-78. Full Article

IMMUNOMODULATING

Lozada-Requena,I., Núñez, C., Alvárez, Y., Kahn, L., & Aguilar, J. (2015). Lymphocyte subsets, dendritic cellsand cytokine profiles in mice with melanoma treated with Uncaria tomentosa. RevistaPeruana de Medicina Experimental y Salud Publica, 32(4), 633-642.(Spanish). Full Article

Núñez,C., Lozada-Requena, I., Ysmodes, T., Zegarra, D., Saldaña, F., & Aguilar,J. (2015). Immunomodulation of Uncaria tomentosa over dendritic cells, il-12 and profile TH1/TH2/TH17 in breast cancer. Revista Peruana de Medicina Experimental y Salud Publica, 32(4), 643-651. Full Article

Montserrat-DeLa Paz, S., De la Puerta, R., Fernandez-Arche, A., Quilez, A. M., Muriana, F.J. G., Garcia-Gimenez, M. D., & Bermudez, B. (2015). Pharmacological effects of mitraphylline from Uncaria tomentosa in primary human monocytes: skew toward M2macrophages. Journal of Ethnopharmacology, 170, 128-135. Full Article

Domingues,A., Sartori, A., Valente, L. M. M., Golim, M. A., Siani, A. C., & Viero, R.M. (2011). Uncaria tomentosa Aqueous‐ethanol Extract Triggers an Immunomodulation toward a Th2 Cytokine Profile. Phytotherapy Research, 25(8), 1229-1235. Full Article

Kang,T. H., Matsumoto, K., Tohda, M., Murakami, Y., Takayama, H., Kitajima, M., ...& Watanabe, H. (2002). Pteropodineand isopteropodine positively modulate the function of rat muscarinic M1 and5-HT2 receptors expressed in Xenopus oocyte. European Journal of Pharmacology,444(1-2), 39-45. Full Article

Karl-HeinzReinhard (1999). Uncaria tomentosa (Willd.) D.C.: Cat's Claw, Una de Gato, or Saventaro. The Journal of Alternative andComplementary Medicine, pp. 143-151 Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Lyme disease

Why this Finnish Doctor Believes in Herbs, Marjo Valonen MD, Townsend Letter, July 2018 Full Article

A Hidden Epidemic: Integrative Treatment of Lyme Disease, Scott Forsgren, March 2009 Full Article

Videos

Conference Presentations

Cowden Support Program for Lyme: Observational Study – Dublin, Ireland – June, 2012 Armin Schwarzbach, MD PhD Full Video

Patient Reports

"Excellent for Lyme & tick-borne co-infections! Feeling better than I do when on antibiotics with this stuff! It works!" -D.V.

"Cumunda is extremely effective for fighting fungal infections, and actually killed off the toenail fungus I'd had for years!  I can't say enough good things about this one!  Cumanda is one great herb that helps me the most with Lyme pain and inflammation."-K.F.

“An essential addition to a mold exposure detox protocol. Highly effective. No side effects for me and my family.” – R.D

“We've tried a few of the microbial defense offerings for my wife's Lyme, but this she likes the most as being the most effective.” – K.A

"I used Goldenseal, Oregon Grape Root, Usnea, Pau d'Arco and countless other supplements but there's nothing that has made me as happy as this Cumanda extract from NutraMedix.  I was desperate.  Now I'm a believer."-L.I.

Dosage Information

30 drops twice daily at least 30 minutes before meals (start with 1 drop in 4 oz. of water adding a drop with each dose).

Protocols

Safety Information

‍An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Cumanda did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.  Full Article

Product Label

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CUMANDA
Cumanda: Male enhancement

Ethnopharmacological relevance: Selected Peruvian Amazon plants are macerated into sugar cane distillates to prepare alcoholic beverages used to improve male sexual performance. The tree bark from Campsiandra angustifolia Spruce ex Benth (Fabaceae), Swartzia polyphylla DC (Fabaceae), Minquartia guianensis Aubl.

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Cumanda: Malaria

Malaria remains one of the most important infectious diseases in the world affecting hundreds of millions of people and causing up to 3 million deaths annually (mostly children). Difficulties in getting access to treatment, for both economic and geographical reasons, result in increased mortality.

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Cumanda: Malaria (Nanay)

In order to evaluate the antimalarial potential of traditional remedies used in Peru, Indigenous and Mestizo populations from the river Nanay in Loreto were interviewed about traditional medication for the treatment of malaria.

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Cumanda: Malaria (identification)

Households in eleven geographically and ethnically distinct areas in Loreto, Peru, were interviewed about their knowledge and use of plants, for the treatment of malaria and leishmaniasis.

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Lyme Disease: A Hidden Epidemic

Many people think of Lyme disease as a simple illness caused by the bite of an infected tick.Though a bite may be a triggering event, this perspective is simplistic and does not take into consideration the numerous issues that both the patient and doctor must consider and treat in order to attain the best possible outcomes. Furthermore, medical literature suggests that Lyme disease is a complex illness which may be transmitted by mosquito bites, blood transfusions, sexual intercourse and many other ways.

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Lyme Disease: Why This Finnish Doctor Believes in Herbs

From an early age, I had a great interest in medicine. When I was young, I thought I wanted to be a brain surgeon. Later, in medical school at the University of Turku, Finland, everything interested me. I was also lucky enough to study a course on acupuncture, something that is not normally taught in Finnish medical schools.

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Cumanda: Acute Oral Toxicity

Cumanda will be used in humans because of the vital importance of carrying out these first-step tests. They will not only guarantee the quality of the product, but will also establish that there are no adverse side effects in humans who take the product.

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Cumanda: Anti-Inflammatory Effect

The method of inducing edemas by applying carragenine to the feet of mice is a classic model for the study of products with anti-inflammatory activity. The byproducts of the metabolism of araquidonic acid via cecloxigenesis and the production of reactive species of oxygen are also involved.

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