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AMANTILLA

RELAX/SLEEP

TO RESOLVE:

  • INSOMNIA
  • STRESS
  • ANXIETY
  • PANIC ATTACKS

General Description

Amantilla is an extract produced from the root of Valeriana officinalis, commonly known as valerian.  The valerian herb in Amantilla has been used medicinally for at least 2,000 years. It has been included in many editions of the United States Dispensatory (Merck) since 1849, which reported the herb's effect on the nervous system. It is very effective in treating stress and anxiety. For some, Amantilla can also be used to induce sleep.  GABA (Gamma-aminobutyric acid), sometimes referred to as the body's natural tranquilizer is one of the amino acids produced in the brain. Valerian extracts like Amantilla stimulate GABA production in quantities sufficient to cause a sedative effect. Therefore, Amantilla may cause sedation by increasing the amount of GABA available in the synaptic clefts in the brain.

Some Reported Medicinal Properties

ANALGESIC

ANODYNE

ANTIANXIETY

ANTIBACTERIAL

ANTIHYPERTENSIVE

ANTIHYSTERIC

ANTI-INFLAMMATORY

ANTISPASMODIC

ANXIOLYTIC

CARMINATIVE

DIURETIC

HYPNOTIC

NERVINE

SEDATIVE

STOMACHIC

Reasearch On Nutramedix Product

Medical Conditions [peer-reviewed journals]

Anxiety

Baek, J. H., Nierenberg, A. A., & Kinrys, G. (2014). Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. Australian & New Zealand Journal of Psychiatry, 48(8), 705-715. Full Article

Depression

Salami, M. R., Safarnejad, A., & Hamidi, H. (2007). Effect of salinity stress on morphological characters of Cuminum cyminum and Valeriana officinalis. Pajouhesh and Sazandegi. Full Article

Orofacial dyskinesia

Fachinetto, R., Villarinho, J. G., Wagner, C., Pereira, R. P., Ávila, D. S., Burger, M. E., ... & Ferreira, J. (2007). Valeriana officinalis does not alter the orofacial dyskinesia induced by haloperidol in rats: role of dopamine transporter. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(7), 1478-1486. Full Article

Parkinson disease

de Oliveria, D. M., Barreto, G., De Andrade, D. V. G., Saraceno, E., Aon-Bertolino, L., Capani, F., ... & Giraldez, L. D. (2009). Cytoprotective effect of Valeriana officinalis extract on an in vitro experimental model of Parkinson disease. Neurochemical Research, 34(2), 215-220. Full Article

Medicinal Properties [peer-reviewed journals]

Anti-inflammatory

Jacobo‐Herrera, N. J., Vartiainen, N., Bremner, P., Gibbons, S., Koistinaho, J., & Heinrich, M. (2006). F‐κB modulators from Valeriana officinalis. Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 20(10), 917-919. Full Article

Antioxidant

Sudati, J. H., Vieira, F. A., Pavin, S. S., Dias, G. R. M., Seeger, R. L., Golombieski, R., ... & Barbosa, N. V. (2013). Valeriana officinalis attenuates the rotenone-induced toxicity in Drosophila melanogaster. Neurotoxicology, 37, 118-126. Full Article

Sudati, J. H., Fachinetto, R., Pereira, R. P., Boligon, A. A., Athayde, M. L., Soares, F. A., ... & Rocha, J. B. T. (2009). In vitro antioxidant activity of Valeriana officinalis against different neurotoxic agents. Neurochemical Research, 34(8), 1372. Full Article

Anxiolytic

Murphy, K., Kubin, Z. J., Shepherd, J. N., & Ettinger, R. (2010). Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine, 17(8-9), 674-678. Full Article

Hattesohl, M., Feistel, B., Sievers, H., Lehnfeld, R., Hegger, M., & Winterhoff, H. (2008). Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Phytomedicine, 15(1-2), 2-15. Full Article

Anticonvulsant

Rezvani, M. E., Roohbakhsh, A., Allahtavakoli, M., & Shamsizadeh, A. (2010). Anticonvulsant effect of aqueous extract of Valeriana officinalis in amygdala-kindled rats: possible involvement of adenosine. Journal of Ethnopharmacology, 127(2), 313-318. Full Article

Carrasco, M. C., Vallejo, J. R., Pardo‐de‐Santayana, M., Peral, D., Martín, M. Á., & Altimiras, J. (2009). Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytotherapy Research, 23(12), 1795-1796. Full Article

Hiller, K. O., & Zetler, G. (1996). Neuropharmacological studies on ethanol extracts of Valeriana officinalis L.: behavioural and anticonvulsant properties. Phytotherapy Research, 10(2), 145-151. Full Article

Antimicrobial

Letchamo, W., Ward, W., Heard, B., & Heard, D. (2004). Essential oil of Valeriana officinalis L. cultivars and their antimicrobial activity as influenced by harvesting time under commercial organic cultivation. Journal of Agricultural and Food Chemistry, 52(12), 3915-3919. Full Article

Improved Sleep Quality

Barton, D. L., Atherton, P. J., Bauer, B. A., Moore Jr, D. F., Mattar, B. I., LaVasseur, B. I., ... & Morgenthaler, T. I. (2011). The use of valeriana officinalis (valerian) in improving sleep in patients who are undergoing treatment for cancer: a phase III randomized, placebo-controlled, double-blind study: NCCTG Trial, N01C5. The Journal of Supportive Oncology, 9(1), 24. Full Article

Murti, K., Kaushik, M., Sangwan, Y., & Kaushik, A. (2011). Pharmacological properties of Valeriana officinalis—a review. Pharmacologyonline, 3, 641-646. Full Article

Fernández, S., Wasowski, C., Paladini, A. C., & Marder, M. (2004). Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis. Pharmacology Biochemistry and Behavior, 77(2), 399-404. Full Article

Leathwood, P. D., Chauffard, F., Heck, E., & Munoz-Box, R. (1982). Aqueous extract of valerian root (Valeriana officinalis L.) improves sleep quality in man. Pharmacology Biochemistry and Behavior, 17(1), 65-71. Full Article

Relaxant

Caudal, D., Guinobert, I., Lafoux, A., Bardot, V., Cotte, C., Ripoche, I., ... & Huchet, C. (2018). Skeletal muscle relaxant effect of a standardized extract of Valeriana officinalis L. after acute administration in mice. Journal of Traditional and Complementary Medicine, 8(2), 335-340. Full Article

Occhiuto, F., Pino, A., Palumbo, D. R., Samperi, S., De Pasquale, R., Sturlese, E., & Circosta, C. (2009). Relaxing effects of Valeriana officinalis extracts on isolated human non‐pregnant uterine muscle. Journal of Pharmacy and Pharmacology, 61(2), 251-256. Full Article

Medicinal Properties
[other journals]

Medical Conditions [other journals]

Videos

Conference Presentations

Patient Reports

"This product is incredible.  I was very stressed out and within 10 minutes after taking just 10 drops, I felt no stress at all.  It works great for my kids too.  It's great to know that I can give them something natural and safe that can calm them down in a few minutes." -I.M.

“Amantilla works well. I use 15 drops in a little water just before going to sleep and it really makes a big difference.” – L.A

“I take 10 drops of this straight under my tongue before bed and start feeling calmer and ready for sleep immediately. It's also great to take before eating so the body can process food on a less-stressed stomach, but I don't always remember to take advantage of that... I'm planning to keep two bottles-- one by my bed and one in my purse to fix that problem!” – L.C

"I thought that I was sleeping well until I took Amantilla, but now I sleep great!  I took 30 drops at bedtime and I slept great.  I did not wake up once during the night and I woke up feeling very refreshed and didn't need coffee to get going.  Whenever I take it I can sleep about 2 hours less than I normally do."-T.I

Dosage Information

Insomnia: take 30 drops in 4 oz. of water at bedtime.  

Severe Insomnia: take 30 drops every 30 minutes beginning 2 hours before bedtime for 5 nights.  

Mild Anxiety: take 10 drops 2-4 times per day.  

Moderate to Severe Anxiety, Panic Attacks: take 10-15 drops every 15 minutes in at least 2 oz. of water until symptoms are resolved. Can also put 2 droppers full (approximately 60 drops) in at least 480 ml (one pint) of water and sip over a 2-hour period, repeating until symptoms are resolved, then take 10 drops 2-4 times per day for maintenance.

Protocols

Safety Information

An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Amantilla did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.

Product Label

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AMANTILLA
Amantilla: In vitro Antioxidant Activity of Valeriana officinalis Against

In the present study, the protective effect of V. officinalis on lipid peroxidation (LPO) induced by different pro-oxidant agents with neuropathological importance was examined.

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Amantilla: Valeriana Officinalis root extract

Valerian root (Valeriana officinalis) is a popular and widely available herbal supplement, primarily used to treat insomnia and anxiety. Until recently, its mechanism of action has remained unknown.

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Amantilla: Valerian and bipolar disorder

Patients with bipolar disorder frequently continue to experience residual anxiety and insomnia between mood episodes. In real-world practice, patients increasingly self-prescribe alternative medicines.

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Amantilla: Toxicity 05-2005

This test was performed with the intention of determining the Acute Toxicity by oral intake of the product to be evaluated, given that this is one of the ways proposed for human intake.

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Amantilla: Sleep Quality

In traditional herbal folklore a number of plants are reputed to have sedative properties. The list includes almonds, camomile, catmint, fennel, hops, indian hemp, lettuce, lime, marjolaine, may blossom, melissa, mullein, oats, orange flower, passion flower, poppy seed, rosemary, willow and valerian.

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Amantilla: Sleep Quality (sedative)

This work investigated the effects of a combined extract of Passiflora alata Dryander and Valeriana officinalis L. (EPV) in rats under going elevated plus maze (EPM) and open-field test (OFT).

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Amantilla: Sleep Quality (Review)

The present review describes the morphological, phytochemical and pharmacology aspects of Valeriana officinalis (Valerianaceae). Valeriana officinalis is a hardy perennial flowering plant. Valerian is native to Europe and Asia and has naturalized in eastern North America.

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Amantilla: Sleep Quality (linarin)

We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S ( – ) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleepinducing properties of HN.

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Amantilla: Sleep Quality (cancer)

Disordered sleep has been found to be common in cancer survivors and contributes to fatigue and impaired overall functioning. The true prevalence and incidence of sleep disorders in the oncology population is not well documented, though reports range from 23%–61%.

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Amantilla: Sedative Effect Test 1

As discussed in numerous international works, the pharmacological study of the above-mentioned effect is indispensable, and guarantees (within the margin of error associated with the technique) that the potential for producing sedative effects in humans will be learned.

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Amantilla: Relaxant

This study investigated the relaxing effects of Valeriana officinalis L. (Valerianaceae) on human uterine muscle. The major uses of this species in Europe are as a sedative and an anxiolytic; it is also used as a spasmolytic to treat gastrointestinal spasm.

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Amantilla: Relaxant (various)

Valerian (Valeriana officinalis) belonging to valerianaceae family is a well known herb and medicinal plant that has been widely used all over the world especially in Europe, China and Middle East.

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Amantilla: Relaxant (Muscle)

Valeriana officinalis L. root extracts are traditionally taken for their sedative and anxiolytic properties and are also used for muscle relaxation. Relaxant effects were clearly observed on smooth muscle whereas data on effects on skeletal muscle are scarce and inconsistent.

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Amantilla: Parkinson disease

Parkinson’s disease (PD) is one of the most important neurodegenerative worldwide disorders. The potential cytoprotective effects of aqueous extract of Valeriana officinalis on rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells were demonstrated.

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Amantilla: Orofacial pain

To evaluate in vivo the association of hypericum (Hypericum perforatum), valerian (Valeriana officinalis) and kava (Piper methysticum) with analgesia by assessing their effects in reducing orofacial pain as well as the possible hepatic, hematologic and biochemical alterations induced by regular administration of these extracts.

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Amantilla: Orofacial dyskinesia

Chronic treatment with classical neuroleptics in humans can produce a serious side effect, known as tardive dyskinesia (TD). Here, we examined the effects of V. officinalis, a medicinal herb widely used as calming and sleep-promoting, in an animal model of orofacial dyskinesia (OD) induced by long-term treatment with haloperidol.

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Amantilla: GABA receptor modulator

Extract of Valeriana officinalis have been used in folkloric medicine for its sedative, hypnotic, tranquilizer and anticonvulsant effects, and may interact with γ-aminobutyric acid (GABA) and/or benzodiazepine sites.

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Amantilla: Depression (ovalbumin)

Neuroimmune factors have been considered as contributors to the pathogenesis of depression. Beside other therapeutic effects, Valeriana officinalis L., have been suggested to have anti-inflammatory effects. In the present study, the effects of V. officinalis L. hydro alcoholic extract was investigated on depression like behavior in ovalbumin sensitized rats.

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Amantilla: Depression (model)

To investigate the effects of Valeriana officinalis extract on behaviors, 5-hydroxytryptamine level and cell proliferation at cerebral hippocampus of a depressive rat model induced by chronic mild stress. Seventy male Sprague-Dawley rats were divided into 7 groups (10 per group) including normal control group, untreated depressive rat model group, negative control group , positive control group, low dosage Valeriana officinalis extract group,medium dosage Valeriana officinalis extract group and high dosage Valeriana officinalis extract group.

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Amantilla: Cognitive function

We hypothesized that valerian root might prevent cognitive dysfunction in coronary artery bypass graft (CABG) surgery patients through stimulating serotonin receptors and anti-inflammatory activity.

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Amantilla: Cancer

The Oxford dictionary defines serendipity as “the faculty of making happy and unexpected discoveries by accident”. During human history, the combination of serendipity and advances in biochemistry fostered the discovery of medicines from bio-sourced materials.

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Amantilla: Antioxidant

Extracts of Valeriana officinalis L. s.l. are used for treating mild sleep disorders and nervous tension. Despite intensive research efforts, the pharmacological actions accounting for the clinical efficacy of valerian remain unclear.

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Amantilla: Antioxidant (Drosophila)

In this study, we investigated the potential protective effects of Valeriana officinalis (V. officinalis) against the toxicity induced by rotenone in Drosophila melanogaster (D. melanogaster).

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Amantilla: Antidepressant

The current study explores data from a 2009 clinical chamomile trial in humans to determine if chamomile provides clinically meaningful antidepressant activity versus a placebo.

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Amantilla: Anticonvulsant

Valeriana officinalis L. (valerian) root extract has been used as an antiepileptic herbal medicine in Iran. Aim of this study: In the present study the effect of valerian extracts on an experimental model of temporal lobe epilepsy (TLE) was evaluated. Moreover, the involvement of adenosine system in the actions of aqueous extract of valerian was evaluated.

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Amantilla: Anticonvulsant (Lorazepam)

There is an increasing interest in the health risks relatedto the use of herbal remedies. Although most consumers think thatphytomedicines are safe and without side effects, interactions betweencomplementary alternative and conventional medicines are being described.

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Amantilla: Anticonvulsant (Behavioural)

The aim of the present study was to find out whether neuropharmacological effects in mice would be exerted by fresh valerian root extracts and some of its isolated fractions.

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Amantilla: Antiallergic

Chamomile is most popular used medicinal plant and extensively consumed as a tea or tisanes. Traditionally this plant was used for treatment of many ailments such as allergy disorders and inflammatory mediated diseases.

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Amantilla: Anti-inflammatory

Valeriana officinalis (Valerianaceae) has been of great interest for its therapeutic uses for treating mild nervous tension and temporary sleeping problems. In traditional European medicine it has been also reported as an antiinflammatory remedy.

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Amantilla: ADHD (3X)

The aim of this three-week, double-blind, placebo-controlled pilot study was to determine the efficacy of homeopathic Valeriana officinalis mother tincture (MT) and 3X potency on attention deficit hyperactivity disorder (ADHD).

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