Amantilla is an extract produced from the root of Valeriana officinalis, commonly known as valerian. The valerian herb in Amantilla has been used medicinally for at least 2,000 years. It has been included in many editions of the United States Dispensatory (Merck) since 1849, which reported the herb's effect on the nervous system. It is very effective in treating stress and anxiety. For some, Amantilla can also be used to induce sleep. GABA (Gamma-aminobutyric acid), sometimes referred to as the body's natural tranquilizer is one of the amino acids produced in the brain. Valerian extracts like Amantilla stimulate GABA production in quantities sufficient to cause a sedative effect. Therefore, Amantilla may cause sedation by increasing the amount of GABA available in the synaptic clefts in the brain.
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"This product is incredible. I was very stressed out and within 10 minutes after taking just 10 drops, I felt no stress at all. It works great for my kids too. It's great to know that I can give them something natural and safe that can calm them down in a few minutes." -I.M.
“Amantilla works well. I use 15 drops in a little water just before going to sleep and it really makes a big difference.” – L.A
“I take 10 drops of this straight under my tongue before bed and start feeling calmer and ready for sleep immediately. It's also great to take before eating so the body can process food on a less-stressed stomach, but I don't always remember to take advantage of that... I'm planning to keep two bottles-- one by my bed and one in my purse to fix that problem!” – L.C
"I thought that I was sleeping well until I took Amantilla, but now I sleep great! I took 30 drops at bedtime and I slept great. I did not wake up once during the night and I woke up feeling very refreshed and didn't need coffee to get going. Whenever I take it I can sleep about 2 hours less than I normally do."-T.I
Insomnia: take 30 drops in 4 oz. of water at bedtime.
Severe Insomnia: take 30 drops every 30 minutes beginning 2 hours before bedtime for 5 nights.
Mild Anxiety: take 10 drops 2-4 times per day.
Moderate to Severe Anxiety, Panic Attacks: take 10-15 drops every 15 minutes in at least 2 oz. of water until symptoms are resolved. Can also put 2 droppers full (approximately 60 drops) in at least 480 ml (one pint) of water and sip over a 2-hour period, repeating until symptoms are resolved, then take 10 drops 2-4 times per day for maintenance.
An acute oral toxicity study was conducted by the University of Guayaquil, Ecuador concluding that Amantilla did not produce toxic effects, thus the product is considered practically innocuous for humans when administered in the acute form. Therefore; studies of acute toxicity at higher doses in humans are not necessary.
In the present study, the protective effect of V. officinalis on lipid peroxidation (LPO) induced by different pro-oxidant agents with neuropathological importance was examined.Download PDFRead more
In traditional herbal folklore a number of plants are reputed to have sedative properties. The list includes almonds, camomile, catmint, fennel, hops, indian hemp, lettuce, lime, marjolaine, may blossom, melissa, mullein, oats, orange flower, passion flower, poppy seed, rosemary, willow and valerian.Download PDFRead more
The present review describes the morphological, phytochemical and pharmacology aspects of Valeriana officinalis (Valerianaceae). Valeriana officinalis is a hardy perennial flowering plant. Valerian is native to Europe and Asia and has naturalized in eastern North America.Download PDFRead more
We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S ( – ) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleepinducing properties of HN.Download PDFRead more
Disordered sleep has been found to be common in cancer survivors and contributes to fatigue and impaired overall functioning. The true prevalence and incidence of sleep disorders in the oncology population is not well documented, though reports range from 23%–61%.Download PDFRead more
As discussed in numerous international works, the pharmacological study of the above-mentioned effect is indispensable, and guarantees (within the margin of error associated with the technique) that the potential for producing sedative effects in humans will be learned.Download PDFRead more
Valeriana officinalis L. root extracts are traditionally taken for their sedative and anxiolytic properties and are also used for muscle relaxation. Relaxant effects were clearly observed on smooth muscle whereas data on effects on skeletal muscle are scarce and inconsistent.Download PDFRead more
Parkinson’s disease (PD) is one of the most important neurodegenerative worldwide disorders. The potential cytoprotective effects of aqueous extract of Valeriana officinalis on rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells were demonstrated.Download PDFRead more
To evaluate in vivo the association of hypericum (Hypericum perforatum), valerian (Valeriana officinalis) and kava (Piper methysticum) with analgesia by assessing their effects in reducing orofacial pain as well as the possible hepatic, hematologic and biochemical alterations induced by regular administration of these extracts.Download PDFRead more
Chronic treatment with classical neuroleptics in humans can produce a serious side effect, known as tardive dyskinesia (TD). Here, we examined the effects of V. officinalis, a medicinal herb widely used as calming and sleep-promoting, in an animal model of orofacial dyskinesia (OD) induced by long-term treatment with haloperidol.Download PDFRead more
Neuroimmune factors have been considered as contributors to the pathogenesis of depression. Beside other therapeutic effects, Valeriana officinalis L., have been suggested to have anti-inflammatory effects. In the present study, the effects of V. officinalis L. hydro alcoholic extract was investigated on depression like behavior in ovalbumin sensitized rats.Download PDFRead more
To investigate the effects of Valeriana officinalis extract on behaviors, 5-hydroxytryptamine level and cell proliferation at cerebral hippocampus of a depressive rat model induced by chronic mild stress. Seventy male Sprague-Dawley rats were divided into 7 groups (10 per group) including normal control group, untreated depressive rat model group, negative control group , positive control group, low dosage Valeriana officinalis extract group,medium dosage Valeriana officinalis extract group and high dosage Valeriana officinalis extract group.Download PDFRead more
Valeriana officinalis L. (valerian) root extract has been used as an antiepileptic herbal medicine in Iran. Aim of this study: In the present study the effect of valerian extracts on an experimental model of temporal lobe epilepsy (TLE) was evaluated. Moreover, the involvement of adenosine system in the actions of aqueous extract of valerian was evaluated.Download PDFRead more
There is an increasing interest in the health risks relatedto the use of herbal remedies. Although most consumers think thatphytomedicines are safe and without side effects, interactions betweencomplementary alternative and conventional medicines are being described.Download PDFRead more