It is important to understand the mechanism of cadmium (Cd) toxicity and its potential risk to the health of a population exposed to Cd occupationally or environmentally. Kidneys inefficiently excrete Cd after prolonged intake and damage to the nephrons occurs, seriously affecting kidney functions. Rats treated with Stevia rebaudiana leaf extract could withstand Cd administered at a dosage of 6 mg/kg of body weight for 30 days. S. rebaudiana is a non-calorific natural sweetener considered as a food supplement. It has been widely used worldwide as a substitute for artificial sweeteners and is safe, unlike artificial sweeteners. The parameters analyzed from kidney samples were total proteins, cholesterol, GOT, GPT, acid phosphatase, alkaline phosphatase, and glutathione reductase. Histological and biochemical observations were also made.