Stress is the psycho physiological sign which is really very complicate to describe. The following medicinal plants such as Caryophyllus Aromaticus, Valerian, Camellia sinensis, Rauvolfia Serpentine, Cinnamomum verum, Brahmi, are claimed as anti-stress, anti-aging, disease prevention and life strengthening activities found in scientific research articles. Along with these herbs Gamma-Aminobutyric Acid also used in health supplement as neuro transmitter. The objective here is to provide a compiled report of these medicinal herbs on stress and relaxation effects and its ethnopharmacological considerations. In the present article, a detailed description of anti-stress and relaxation effects has been presented. All the findings were correlated with the pharmacokinetic activities to assess the above mentioned herbs.