Vitamin C concentrations in the plasma and leukocytes rapidly decline during infections and stress.

Obstructive sleep apnea (OSA) is associated with oxidative stress, endothelial dysfunction, and increased cardiovascular morbidity and mortality.

Free radical reactions occur in the human body and food systems.

Excess free radical production underlies the pathogenesis of diseases like atherosclerosis, carcinogenesis, diabetes, cataract and accelerated ageing.

Cigarette smoking is a well established risk factor for cardiovascular disease, and it affects both the coronary and the peripheral circulation.

The presence of free radicals in the body causes cell and tissue damage.

Vitamin C is an important antioxidant in human, capable of scavenging oxygen-derived free radicals.

Lipid peroxidation may be important in the pathogenesis of atherosclerotic cardiovascular disease, particularly in its earliest stages.

Early clinical studies showed that high-dose vitamin C, given by intravenous and oral routes, may improve symptoms and prolong life in patients with terminal cancer.

Vitamin C is required for collagen synthesis and biosynthesis of certain hormones and recommended dietary intake levels are largely based these requirements.

Cisplatin (cis-diamminedichloroplatinum II) is one of the most potent chemotherapeutic antitumor drugs.

Wound healing in African catfish, Clarias gariepinus, fed diets supplemented with ascorbic acid was studied under laboratory conditions.

Multidisciplinary evidence indicates that enhanced lipid peroxidation is associated with accelerated atherogenesis and that self-selected use of antioxidant supplements is associated with reduced atherosclerosis.

The health benefit of fruit juices have been ascribed, in part, to phenolic antioxidants.

Pressure ulcers are areas of damage to the skin and underlying tissue that usually occur over bony protrusions such as elbows, heels and hips.

To express the antioxidant capacity of plant foods in a more familiar and easily understand manner ( equivalent to vitaminc C mg/100g), two stable radical species, ABTS and DPPH, commonly used for anitoxidant activity measurements, were employed independently to evaluate their efficacies using apple polyphenolic extracts and seven polyphenolic standards including synthetic Trolox.

Vitamin C is an essential dietary nutrient required as a co-factor for many enzymes, and humans are among the few animals that lack the ability to synthesize the compound from glucose.

Vitamin C (ascorbic acid) is required in the diets of humans and several other species that lack the terminal enzyme in its synthetic pathway, L-gulonolactone oxidase.

Vitamin C is the main water-soluble antioxidant in human plasma and is hypothesized to have a protective role in the development of atherosclerotic heart disease by inhibiting low-density lipoprotein oxidation.

A large scale double-blind trial was conducted to test the claim that the intake of one gram of vitamin C per day substantially reduces the frequency and duration of "colds".

Vitamin C in humans must be ingested for survival.

Vitamin C is marketed as a dietary supplement, partly because of its ‘antioxidant’ properties.

The role of vitamin C in the prevention and treatment of the common cold has been a subject of controversy for at least 60 years.

Ascorbate (vitamin C) is a vital antioxidant molecule in the brain.

My previous experience with the utilization of ascorbic acid in the treatment of viral diseases led me to hypothesize that ascorbate would be of value in the treatment of AIDS (acquired immune deficiency syndrome).

Nonalcoholic steatohepatitis (NASH) is one of the most common forms of liver disease and is frequently associated with clinical conditions such as obesity, type II diabetes mellitus, hyperlipidemia, and hypertension.