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Effect of Achillea millefolium extract in wound healing of rabbit

Objective: To evaluate the effect of hydroalcoholic extract of  Achillea millefolium  (yarrow)  on the wound healing in rabbit.

Material and methods: Wound healing effect of yarrow extract in eucerin base at  concentrations of  2, 5 and 10% w/w were tested topically on full thickness excision wound in rabbits. Such effect was compared with phenytoin cream (1%) as a standard healing agent.

Results: Yarrow extract creams significantly reduced the rate of wound healing compared to no-treatment, eucerin. Five percent yarrow  extract cream showed better healing profile, and the rate of healing was significantly (p<0.01) better than other groups.

Conclusion: Yarrow showed a considerable potential for wound healing possibly by accelerating the collagenation and proliferation phase of wound healing.