In Taiwan, 26 individuals per 100,000 died from lung cancer each year, based on reports from the “People Health Bureau of Taiwan”. Surgery, radiotherapy, and chemo-therapy are used for treating lung cancer patients. However, those treatments are not satisfactory. In-duction of cell cycle arrest and/or apoptosis in lung cancer cells has been considered an influential treatment strategy. Many researchers have focused on selectively killing cancer cells or reducing cell number through the induc-tion of cell cycle arrest and apoptosis.
Morphological changes in apoptotic cells include cell membrane blebbing, DNA or chromatin condensation, and caspase activation [8-10]. Previous studies have dem-onstrated that the cell membrane death receptor played an important role in apoptosis. Death receptor signaling is mediated through FasL and Fas/CD95 recep-tor protein interaction followed by activation of caspase-8. The activation of caspase-3 by caspase-8 is re-sponsible for the cleavage of cellular substrates. Cleavage of cellular substrates degrades the chromosomes into fragments during apoptosis.