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Anti-inflammatory effects of a Houttuynia cordata supercritical extract

Traditionally, Houttuynia (H.) cordata Thunb has been used as an Oriental medicine for the treatment of inflam­matory diseases such as ulcerative colitis. Previous studies showed that H. cordata extracts had antiviral and antibacterial, antiallergic, antioxidant and antimutagenic activities.

The major constituents of H. cordata essential oil included methyl nonyl ketone, β-myrcene, β-pinene, α-pinene, α-terpineol and n-decanoic acid. The anti­inflammatory effects of the oil were also demonstrated.

In the present study, we investigated the anti-inflammatory activity of H. cordata supercritical extract (HSE) in both macrophages and a carrageenan-induced air pouch inflam­mation model.