Traditionally, Houttuynia (H.) cordata Thunb has been used as an Oriental medicine for the treatment of inflammatory diseases such as ulcerative colitis. Previous studies showed that H. cordata extracts had antiviral and antibacterial, antiallergic, antioxidant and antimutagenic activities.
The major constituents of H. cordata essential oil included methyl nonyl ketone, β-myrcene, β-pinene, α-pinene, α-terpineol and n-decanoic acid. The antiinflammatory effects of the oil were also demonstrated.
In the present study, we investigated the anti-inflammatory activity of H. cordata supercritical extract (HSE) in both macrophages and a carrageenan-induced air pouch inflammation model.