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Immunomodulatory Potential of Inula Helenium L.

Inula helenium L. (Asteraceae) is a widely occurring perennial herb in Europe and East Asia. Its active components belong mostly to sesquiterpene lactones class - eudesmanolides (alantolactone, isoalantolactone, 4α,5α-Epoxyalantolactone, diplophyllin) and germacranolides (isocostunolide) (Seca et al., 2014) being used as anti-inflammatory, anti-microbial, and anti-cancer agents. The root and the rhizome are the most used plant parts for various preparations - infusion, powder, wine, syrup having the following therapeutic indications: antiseptic in exanthema, bacterial and fungal dermatitis; antipruritic in dry patches; to facilitate urinary and digestive functions; to treat symptomatic cough and bronchitis; to treat failure by the dyspeptic hepatobiliary or biliary dyskinesia; as an adjunct in the fight against hyperglycemia and obesity (Ghedira et al., 2011).