Oxidative stress is the imbalance between the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) and their clearance by the antioxidants. The antioxidant system contains enzymes (superoxide dismutase “SOD”, glutathione peroxidase “GPX”, glu-tathione reductase “GR” and catalase), molecules (reduced glutathione “GSH”) and nutrients (Sánchez, Calpena, & Clares, 2015; Cheng, Lu, & Yen, 2017). Oxidative stress accompanies most of the inﬂammatory diseases, which can be initiated by many factors, such as; bacterial infection, environmental pollution, and chemical injury. This will result in the induction of the inﬂammatory mediators, such as nuclear factor-kappa (NF-к) B, inducible nitric oxide synthase (iNOS), cyclooxygenase-(COX)-2 and tumor necrosis factor (TNF)-α. Both oxidative stress and inﬂammation are responsible for the pathogenesis and development ofvarious chronic diseases, such as cancer, hepatic diseases and auto-immune diseases (Sánchez et al., 2015). Corticosteroids, such as dex-amethasone (Dex) are used extensively as powerful anti-inﬂammatory drugs but they cause serious adverse eﬀects after administration for long-term. Therefore, discovering new potent antioxidant and anti-inﬂammatory natural products is of great importance. Recently, many algae and higher plants have been shown to be useful in the treatment of many diseases that associated with oxidative stress and inﬂammation.