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An Investigation of the Effects of Curcumin on Anxiety and Depression in Obese Individuals: A Randomized Controlled Trial


Objective: To investigate the effectiveness of curcumin, a natural polyphenolic compound with antioxidant and anti-inflammatory activities, on the frequency of symptoms of anxiety and depression in obese individuals.

Methods:: In this double blind, cross-over trial, 30 obese subjects were randomized to receive either curcumin (1 g/day) or placebo for a period of 30 days. Following a wash-out interval of 2 weeks,  Following a wash-out interval of 2 weeks, each subject was crossed over to the alternative regimen for a further 30 days. Severity of anxiety and depression was assessed at baseline and at weeks 4, 6 and 10 of the trial using the Beck Anxiety Inventory (BAI) and  Beck Depression Inventory (BDI) scales, respectively.

Results: Mean BAI score was found to be significantly reduced following curcumin therapy ( following curcumin therapy (P=0.03). However, curcumin supplementation did not exert any significant impact on cant impact on BDI scores (P=0.7).

Conclusion: Curcumin has a potential anti-anxiety effect in individuals with obesity.