Turmeric has potent antiviral, antimutagenic, anti-inflammatory, and antioxidant properties and is even used in the treatment of injuries to the skin. However, the mechanisms underlying the hepatoprotective, and other chemoprotective effects elicited by Curcuma longa Linn. extract (CLE), in association with Nrf2 upregulation, remain poorly understood. In the present study, we investigated whether CLE pretreatment exerted protective effects on CCl-induced hepatotoxicity in rats. In addition, we attempt to elucidate the possible mechanisms underlying any such protective effect.