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Safety and antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats

Achillea millefolium L. (Asteraceae), popularly known as “yarrow”, is a widely distributed medicinal plant that has been used for over 3000 years. Popular indications of this specie include treatment of wounds, hemorrhages, headaches, inflammation, pain, spasmodic diseases, flatulence, and dyspepsia. Some of these reputed folk effects have been determined showing the potential medicinal use of the plant. The medicinal properties of Achillea millefolium are worldwide recognized and the plant is included in the national Pharmacopoeias of countries such as Germany, Czech Republic, France and Switzerland. In Brazil, Achillea millefolium is included in the list of the 16 medicinal plants of the “Verde Sa´ude” (Green Health), a public health phytotherapy Agency supported by the Municipal Health Secretary of Curitiba (PR, Brazil) which includes the anti-inflammatory, analgesic, anti-spasmodic and antiseptic properties of the plant.