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Establishment of the potential anti-inflammatory effect of the product known as Quina

The method of inducing edemas by applying carragenin to the feet of mice is a classic model for the study of products with anti-inflammatory activity.  The by-products of the metabolism of araquidonic acid via cecloxigenesis and the production of reactive species of oxygen are also involved.  It is reported that there are four principle phases to this edema: an initial phase in which histamine and serotonin is released; a second phase measured by kinins; a third phase (about 5 hours) in which prostaglandins are liberated; and a fourth phase related to the local infiltration of neutrophils and their activiation.  This model has recently been recommended as very useful for the evaluation of anti-oxidant products with anti-inflammatory properties and free radicals of oxygen inhibitors.