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In vitro Synergistic Antibacterial Effect of Ozonized Antarctic Krill Oil in Combination with Antibiotics against Bacterial Skin Pathogens

Ozonized Antarctic krill oil (OAKO) exhibited a significant antibacterial activity against bacterial skin pathogens that cause various skin infectious diseases such as Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcusaureus, and Pseudomonas aeruginosa. Minimum inhibitory concentration (MIC)values of OAKO against these bacteria ranged from 128 to 256 μg/ml. Furthermore, MIC values of antibiotics such as erythromycin and lincomycin were dramatically reduced in combination with OAKO against antibiotic resistant bacteria. The combination of OAKO with erythromycin exhibited significant synergistic effect with fractional inhibitory concentration (ΣFIC)0.375 and 0.503 against erythromycin-resistant P. acnes and P. aeruginosa,respectively. Hence, these results indicate synergistic antibacterial effects ofrestoration traditional antibiotics with OAKO