Ibuprofen (IBU) is a Non-steroidal anti-inflammatory drug used in the treatment of pain, fever and in inflammation. Coriandrum sativum is cultivated for its aromatic and medicinal uses. The present study aims to evaluate the protective effect of Coriandrum sativum volatile oil on hepatotoxicity of IBU in rats. Five groups of albino rats were used.Group l(control),groupll (C.sativum oil,40 mg/kg B.W. for 14 day), group lll (IBUgroup,100mg/kg bodyweight B.W., for 14 day), group lV(IBU+ C.sativum oil) and groupV (recovery group).The activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured in the liver of different groups addition to the histological examination of the sections of liver. The results showed that IBU caused a significant decrease in the activity of ALT and AST in the liver. The histological examination of the liver showed many pathological changes. Administration of coriander volatile oil in the combination with IBU was able to significantly increase the activity of both AST and ALT, in the liver and caused a significant decrease in the deleterious effect induced by IBU. The present results confirm that the antioxidant activity of volatile oil of the Coriandrum sativum L., against hepatotoxicity of IBU.