Morinda citrifolia Linn (Rubiaceae), popularly known as noni, is widely used in folk medicine in the form of decoction and infusion, particularly as anti-inflammatory, depurative, anti-rheumatic and antiulcer remedy. The infusion of M. citrifolia L. leaves is used in popular medicine in Northeast of Brazil to treat inflammatory and painful diseases. The present study was designed to evaluate the antioxidant potential and the anti-inflammatory effect of the aqueous extract from the dried leaves from M. citrifolia L. (EAMC). The free radical scavenging activities were determined for different concentrations using in vitro models, and the inflammatory processes were evaluated by carrageenan-induced pleurisy. The
study results indicated a significant dose-dependent antioxidant effect by noni extract as evaluated by total antioxidant potential (TRAP) and total antioxidant reactivity (TAR) assays. Noni extracts also exhibited modest catalase-like activity, and was able to inhibit the levels of proinflammatory cytokines. All experimental data indicate that the EAMC have not only remarkable antioxidant properties but also potential anti-inflammatory properties.